SP0212 TGFBeta: An Ambivalent Role in Bone and Cartilage

Osteoarthritis (OA) is a highly prevalent joint cartilage degeneration disorder. Articular cartilage and subchondral bone act as a functional unit. TGFb in maintenance of articular cartilage metabolic homeostasis and structural integrity has been well established. However, understanding of subchondral bone in OA is still limited. In our recent study, we investigated subchondral bone-articular cartilage as a functional unit in the joints during...