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Annals of the Rheumatic Diseases
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14.30
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47980
Papers 48040
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#1Adrian Ys Lee (Flinders University)H-Index: 1
#2Tim Chataway (Flinders University)H-Index: 20
Last.Jing Jing Wang (Flinders University)
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A cause of potentially devastating pathologies, cryoglobulins are immunoglobulin complexes that precipitate out of serum at temperatures lower than 37°C. They often arise secondary to underlying conditions, such as hepatitis infections, although may be idiopathic. Brouet et al 1 classified cryoglobulins according to their immunoglobulin composition: type I (monoclonal), type II (mixed with monoclonal rheumatoid factor (RF)) and type III (mixed with polyclonal RF). Detection of cryoglobulins has ...
1 CitationsSource
Objectives Recent evidences have revealed that anti-SSA/SSB antibodies, the major autoantibodies in Sjogren9s syndrome (SS), are produced in salivary glands. This study aims to clarify overall of autoantibody production at lesion site, including anti-centromere antibody (ACA)-positive SS. Methods Antibodies of antibody-secreting cells in human salivary glands were produced as recombinant antibodies. The reactivity of these antibodies and their revertants were investigated by ELISA and newly deve...
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Objective The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome’s role in RA pathology by a comprehensive metagenome-wide association study (MWAS). Methods We conducted MWAS of the RA gut microbiome in the Japanese population (ncase=82, ncontrol=42) by using whole-genome shotgun sequencing of high depth (average 13 Gb per sample). Our MWAS cons...
1 CitationsSource
Organic anion transporter 10 (OAT10), also known as SLC22A13, has hitherto been identified as a urate transporter by in vitro analyses.1 Despite the reported expression of OAT10 on the apical membrane of the renal proximal tubular cells,1 the physiological impact of OAT10 on urate handling in humans remains to be elucidated. Accumulating evidence suggests that functional variants of already-characterised, physiologically important urate transporters—URAT1/SLC22A12, GLUT9/SLC2A9, BCRP/ABCG2 and N...
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#1Yoshiya Tanaka (University of Occupational and Environmental Health Japan)H-Index: 54
#2Koji Oba (Hokkaido University)H-Index: 24
Last.Norihiro Sato (Hokkaido University)H-Index: 18
view all 24 authors...
Objectives The aim of this study is to determine whether the ‘programmed’ infliximab (IFX) treatment strategy (for which the dose of IFX was adjusted based on the baseline serum tumour necrosis factor α (TNF-α)) is beneficial to induction of clinical remission after 54 weeks and sustained discontinuation of IFX for 1 year. Methods In this multicentre randomised trial, patients with IFX-naive rheumatoid arthritis with inadequate response to methotrexate were randomised to two groups; patients in ...
2 CitationsSource
#1Jian Yin ('SMMU': Second Military Medical University)H-Index: 4
#2Peter R. SternesH-Index: 6
Last.Huji Xu (THU: Tsinghua University)H-Index: 1
view all 12 authors...
Objectives Diverse evidence including clinical, genetic and microbiome studies support a major role of the gut microbiome in the common immune-mediated arthropathy, ankylosing spondylitis (AS). We set out to (1) further define the key microbial characteristics driving disease, and (2) examine the effects of tumour necrosis factor-inhibitor (TNFi) therapy upon the microbiome. Methods The stools from a case–control cohort of 250 Han-Chinese subjects underwent shotgun metagenomic sequencing. All su...
1 CitationsSource
A new decade of the 21st century is starting. We have experienced multiple shake-ups in the course of the last decade, the ‘teens-decade’—political ones and social ones, such as the climate crisis which affects us globally and might even influence the epidemiology of rheumatic diseases in the not too distant future. Hopefully the new decade will find solutions for some of the burning problems of the planet and its societies. In rheumatology, the first decade of this millennium brought novel ther...
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#1Liang KuangH-Index: 3
#2Jiangyi Wu (Southwest General Health Center)
Last.Lin ChenH-Index: 21
view all 28 authors...
Objectives This study aims to investigate the role and mechanism of FGFR3 in macrophages and their biological effects on the pathology of arthritis. Methods Mice with conditional knockout of FGFR3 in myeloid cells (R3cKO) were generated. Gait behaviours of the mice were monitored at different ages. Spontaneous synovial joint destruction was evaluated by digital radiographic imaging and μCT analysis; changes of articular cartilage and synovitis were determined by histological analysis. The recrui...
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IgG4-related disease (IgG4-RD) can cause fibroinflammatory lesions in nearly any organ. Correlation among clinical, serological, radiological and pathological data is required for diagnosis. This work was undertaken to develop and validate an international set of classification criteria for IgG4-RD. An international multispecialty group of 86 physicians was assembled by the American College of Rheumatology (ACR) and the European League Against Rheumatism (EULAR). Investigators used consensus exe...
1 CitationsSource
The therapeutic management of Sjogren syndrome (SjS) has not changed substantially in recent decades: treatment decisions remain challenging in clinical practice, without a specific therapeutic target beyond the relief of symptoms as the most important goal. In view of this scenario, the European League Against Rheumatism (EULAR) promoted and supported an international collaborative study (EULAR SS Task Force) aimed at developing the first EULAR evidence and consensus-based recommendations for t...
2 CitationsSource
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