Annals of the Rheumatic Diseases
Papers 47770
1 page of 4,777 pages (47.8k results)
Published on Jul 12, 2018in Annals of the Rheumatic Diseases14.30
Haijun Wu1
Estimated H-index: 1
(Academy of Medical Sciences, United Kingdom),
G Zhang1
Estimated H-index: 1
(Academy of Medical Sciences, United Kingdom)
+ 1 AuthorsChanghong Liang1
Estimated H-index: 1
(Academy of Medical Sciences, United Kingdom)
MRI can visualise and depict bone marrow oedema, which is known to be a strong independent predictor for radiographic progression in patients with rheumatoid arthritis (RA).1 2 Recent advances in dual-energy CT have enabled the direct visualisation of traumatic bone marrow oedema with high sensitivity and specificity through implementation of virtual non-calcium (VNCa) images.3–7 We have recently read Jans and colleagues’ letter8 entitled, ‘Dual-energy CT: a new imaging modality for bone marrow ...
Published on Jun 8, 2019in Annals of the Rheumatic Diseases14.30
Ruifang Liang4
Estimated H-index: 4
Rosebeth Kagwiria3
Estimated H-index: 3
+ 9 AuthorsMax E Kraner
Objectives Systemic sclerosis (SSc) is characterised by aberrant hedgehog signalling in fibrotic tissues. The hedgehog acyltransferase (HHAT) skinny hedgehog catalyses the attachment of palmitate onto sonic hedgehog (SHH). Palmitoylation of SHH is required for multimerisation of SHH proteins, which is thought to promote long-range, endocrine hedgehog signalling. The aim of this study was to evaluate the role of HHAT in the pathogenesis of SSc. Methods Expression of HHAT was analysed by real-time...
Published on Jun 6, 2019in Annals of the Rheumatic Diseases14.30
Hilde Berner Hammer22
Estimated H-index: 22
Brigitte Michelsen5
Estimated H-index: 5
(Hospital of Southern Norway)
+ 5 AuthorsTore K. Kvien82
Estimated H-index: 82
Objectives Joint swelling and tenderness are considered a proxy for inflammation in patients with rheumatoid arthritis (RA). With ultrasound-detected inflammation as reference, our objectives were to explore on patient and joint level the associations between ultrasound synovitis and joint swelling, tenderness and patient-reported joint pain (PRJP). Methods 209 patients with established RA were examined six times during 12 months with assessment of 32 joints in upper/lower extremities for joint ...
Published on Jul 5, 2019in Annals of the Rheumatic Diseases14.30
Dennis McGonagle Mrcip69
Estimated H-index: 69
(University of Leeds),
Iain B. McInnes87
Estimated H-index: 87
(Glas.: University of Glasgow)
+ 2 AuthorsRobert J. Moots42
Estimated H-index: 42
(University of Liverpool)
Although the pathogenic mechanisms underlying axial spondyloarthritis (axSpA) and psoriatic arthritis (PsA) are not fully elucidated, several lines of evidence suggest that immune responses mediated by interleukin 17A (IL-17A) play a pivotal role in both diseases. This is best highlighted by the significant clinical efficacy shown with inhibitors of IL-17A in treating axSpA and PsA. Nevertheless, a number of knowledge gaps exist regarding the role of IL-17A in the pathophysiology of spondyloarth...
Published on Mar 22, 2019in Annals of the Rheumatic Diseases14.30
Stefan Vordenbäumen10
Estimated H-index: 10
(HHU: University of Düsseldorf),
Ralph Brinks14
Estimated H-index: 14
(HHU: University of Düsseldorf)
+ 2 AuthorsM. Schneider48
Estimated H-index: 48
(HHU: University of Düsseldorf)
Fabry disease (FD) is a rare lysosomal storage disorder caused by mutations of the alpha-galactosidase A gene ( GLA ) which causes premature morbidity due to organ dysfunction following deposition of globotriaosylceramide (Gb3).1 Presenting symptoms include musculoskeletal pain such as acroparesthesias2 which often result in rheumatological consultations.3 Concerns have been raised that patients with FD are often falsely attributed with classical rheumatological diagnoses, precluding early effec...
Published on Mar 18, 2019in Annals of the Rheumatic Diseases14.30
Thierry Dervieux13
Estimated H-index: 13
Joel M. Kremer69
Estimated H-index: 69
Michael E. Weinblatt77
Estimated H-index: 77
(Brigham and Women's Hospital)
Methotrexate (MTX) is known to improve blood levels and clinical outcome to anti-tumour necrosis factor (anti-TNF) therapy by reducing the formation of antidrug antibodies.1 Recent findings indicate that MTX prevents immunisation against TNF inhibitors through de novo purine biosynthesis inhibition and generation of immunosuppressive adenosine.2 This effect is mediated by activation of MTX prodrug to MTX polyglutamates (MTXPG), and we previously reported that MTXPG levels were associated with im...
Published on Apr 20, 2019in Annals of the Rheumatic Diseases14.30
Sizheng Steven Zhao , Gary J. Macfarlane79
Estimated H-index: 79
(Aberd.: University of Aberdeen)
+ 4 AuthorsNicola J. Goodson17
Estimated H-index: 17
Acute anterior uveitis (AAU) is the the most common extra-axial manifestation in axial spondyloarthritis (axSpA) and can lead to visual impairment if untreated. Cross-sectional axSpA studies have consistently reported lower odds of AAU in current smokers than ex or never smokers,1 2 which is in contrast to higher AAU risk among smokers in the general population.3 One explanation for this apparent paradox is behaviour change; those with AAU may be more likely to quit smoking. However, this does n...
Published on Jun 27, 2018in Annals of the Rheumatic Diseases14.30
Carlos Antonio Moura2
Estimated H-index: 2
Carlos Geraldo Moura2
Estimated H-index: 2
(Escola Bahiana de Medicina e Saúde Pública)
Eventually, we heard the French proverb “ dans la medicine comme dans l’amour, ni jamais, ni toujours ” suggesting that medicine is unpredictable. The introduction of new therapeutic interventions in clinical practice accompanies this rule, arising both certainties and doubts, until experiences are shared to generate a conduit guide. However, just like any guide, medical guidelines should work as compasses, not as anchors, because real-life medicine constantly exposes physicians to new and unfam...
Published on May 21, 2019in Annals of the Rheumatic Diseases14.30
Arthur Kavanaugh71
Estimated H-index: 71
Alice Gottlieb82
Estimated H-index: 82
+ 6 AuthorsDiamant Thaçi35
Estimated H-index: 35
Objective Determine the contribution of joint and skin improvements to health-related quality of life (HRQoL) in patients with psoriatic arthritis (PsA). Methods SPIRIT-P1 and SPIRIT-P2 are phase 3 trials investigating ixekizumab, an interleukin-17A antagonist, in the treatment of patients with active PsA. Patients were randomised to ixekizumab or placebo. Outcomes included the Disease Activity Index for Psoriatic Arthritis (DAPSA), the Psoriasis Area and Severity Index (PASI), the European Qual...
Published on May 29, 2019in Annals of the Rheumatic Diseases14.30
Stephanie Finzel20
Estimated H-index: 20
Sebastian Kraus10
Estimated H-index: 10
(FAU: University of Erlangen-Nuremberg)
+ 4 AuthorsGeorg Schett88
Estimated H-index: 88
(FAU: University of Erlangen-Nuremberg)
Objective To compare the effects of interleukin-6 (IL-6) receptor and tumour necrosis factor inhibition on inducing repair of existing bone erosions in patients with very early rheumatoid arthritis (RA). Methods Prospective non-randomised observational study in patients with active erosive RA with inadequate response to methotrexate (MTX) receiving either tocilizumab (TOC) monotherapy or adalimumab (ADA) with MTX for 52 weeks. Erosion volumes were assessed in metacarpal heads (MCH) and the radiu...