Original paper
Sodium Salts and Solvate of Rebamipide: Synthesis, Structure, and Pharmacokinetic Study
Abstract
Two sodium salts (Na(CH3CH2OH) (HReb) (1) and Na2(H2O)4(Reb) (2)), one methanol solvate (H2Reb·CH3OH (3)), and one methyl ester (4) of the minimally soluble drug, rebamipide (H2Reb), used for the treatment of gastric ulcers and gastritis have been synthesized. For the first time the structure of rebamipide has been determined by single crystal X-ray diffraction. Although salts 1 and 2 were prepared under the similar conditions, their structures...
Paper Details
Title
Sodium Salts and Solvate of Rebamipide: Synthesis, Structure, and Pharmacokinetic Study
Published Date
May 9, 2016
Journal
Volume
16
Issue
6
Pages
3180 - 3189
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Notes
History