Sodium Salts and Solvate of Rebamipide: Synthesis, Structure, and Pharmacokinetic Study

Two sodium salts (Na(CH3CH2OH) (HReb) (1) and Na2(H2O)4(Reb) (2)), one methanol solvate (H2Reb·CH3OH (3)), and one methyl ester (4) of the minimally soluble drug, rebamipide (H2Reb), used for the treatment of gastric ulcers and gastritis have been synthesized. For the first time the structure of rebamipide has been determined by single crystal X-ray diffraction. Although salts 1 and 2 were prepared under the similar conditions, their structures...