New light on prions: putative role of co-operation of PrPc and Aβ proteins in cognition

A seminal article of Takahashi et al. reporting concomitant accumulation of cellular prion protein (PrPc) and β-amyloid (Aβ) in dystrophic neurites, within neuritic plaques raised an exciting issue that is important for our understanding of mechanisms of neurodegeneration. The mentioned authors interpreted their findings rather cautiously, however since the time of their publication, several reports representing different approaches and methods...