Match!

Neural reactivity to rewards and losses in offspring of mothers and fathers with histories of depressive and anxiety disorders.

Published on May 1, 2014in Journal of Abnormal Psychology
· DOI :10.1037/a0036285
Autumn Kujawa21
Estimated H-index: 21
,
Greg Hajcak Proudfit23
Estimated H-index: 23
,
Daniel N. Klein73
Estimated H-index: 73
Abstract
Abstract Depression appears to be characterized by reduced neural reactivity to receipt of reward. Despite evidence of shared etiologies and high rates of comorbidity between depression and anxiety, this abnormality may be relatively specific to depression. However, it is unclear whether children at risk for depression also exhibit abnormal reward responding, and if so, whether risk for anxiety moderates this association. The feedback negativity (FN) is an event-related potential component sensitive to receipt of rewards versus losses that is reduced in depression. Using a large community sample (N = 407) of 9-year-old children who had never experienced a depressive episode, we examined whether histories of depression and anxiety in their parents were associated with the FN following monetary rewards and losses. Results indicated that maternal history of depression was associated with a blunted FN in offspring, but only when there was no maternal history of anxiety. In addition, greater severity of maternal depression was associated with greater blunting of the FN in children. No effects of paternal psychopathology were observed. Results suggest that blunted reactivity to rewards versus losses may be a vulnerability marker that is specific to pure depression, but is not evident when there is also familial risk for anxiety. In addition, these findings suggest that abnormal reward responding is evident as early as middle childhood, several years prior to the sharp increase in the prevalence of depression and rapid changes in neural reward circuitry in adolescence.
  • References (0)
  • Citations (72)
📖 Papers frequently viewed together
125 Citations
264 Citations
4 Authors (Dan Foti, ..., Greg Hajcak)
249 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References0
Newest
Cited By72
Newest
#1Autumn Kujawa (Vandy: Vanderbilt University)H-Index: 21
#2Kodi B. Arfer (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last. Daniel N. Klein (SBU: Stony Brook University)H-Index: 73
view all 6 authors...
Problems in mother–child relationships are thought to be key to the intergenerational transmission of depression. To evaluate neural and behavioral processes involved in these pathways, we tested e...
Source
#1Autumn Kujawa (Vandy: Vanderbilt University)H-Index: 21
#2Daniel N. Klein (SBU: Stony Brook University)H-Index: 73
Last. Anna Weinberg (McGill University)H-Index: 27
view all 4 authors...
Abstract Reduced activation of positive valence systems (PVS), including blunted neural and physiological responses to pleasant stimuli and rewards, has been shown to prospectively predict the development of psychopathology. Yet, little is known about how reduced PVS activation emerges across development or what implications it has for prevention. We review genetic, temperament, parenting, and naturalistic and laboratory stress research on neural measures of PVS and outline developmentally-infor...
Source
#1Peter E. Clayson (USF: University of South Florida)H-Index: 20
#2Kaylie A. Carbine (BYU: Brigham Young University)H-Index: 6
Last. Michael J. Larson (BYU: Brigham Young University)H-Index: 34
view all 3 authors...
Abstract Performance-monitoring event-related brain potentials (ERPs), such as the error-related negativity (ERN) and reward positivity (RewP), are advocated as biomarkers of depression symptoms and risk. However, a recent meta-analysis indicated effect size heterogeneity in the ERN and RewP literatures. Hence, advocating these ERPs as biomarkers of depression might be premature or possibly misguided due to the selective reporting of significant analyses on the part of researchers (e.g., p-hacki...
3 CitationsSource
#1Samantha Pegg (Vandy: Vanderbilt University)
#2Autumn Kujawa (Vandy: Vanderbilt University)H-Index: 21
Abstract Individual differences in reward responsiveness can be reliably measured at the neurophysiological level using the reward positivity (RewP) event-related potential (ERP). Alterations in reward responsiveness impact physical and psychological health. In particular, prior research indicates that a reduced RewP prospectively predicts depressive symptoms. However, it remains unclear whether RewP can be modified through intervention or prevention. The present study examined the effects of a ...
2 CitationsSource
#1Gabriela A. Nagy (Duke University)H-Index: 1
#2Paul Cernasov (UNC: University of North Carolina at Chapel Hill)
Last. Moria J. Smoski (Duke University)H-Index: 28
view all 6 authors...
Behavioral Activation (BA) is a contemporary third-wave psychosocial treatment approach that emphasizes helping individuals become more active in ways that are meaningful to them as a means of impr...
Source
#1Aliona Tsypes (Binghamton University)H-Index: 7
#2Brandon E. Gibb (Binghamton University)H-Index: 37
The Reward Positivity (RewP) event-related potential (ERP), generally quantified as the difference between neural responsiveness to monetary gains (RewP-Gain) and losses (RewP-Loss) is commonly used as an index of neural reward responsiveness. Despite the popularity of this ERP component in studies of reward processing, knowledge about the role of state-related influences on the RewP is limited. The present study examined whether RewP amplitudes may differ based on when during the day they are a...
Source
A high-performance, wide dynamic range, fully-integrated neural interface is one key component for many advanced bidirectional neuromodulation technologies. In this paper, to complement the previously proposed frequency-shaping amplifier (FSA) and high-precision electrical microstimulator, we will present a proof-of-concept design of a neural data acquisition (DAQ) system that includes a 15-bit, low-power Delta-Sigma analog-to-digital converter (ADC) and a real-time spike processor based on one ...
Source
#1Julia KlawohnH-Index: 8
Last. Greg HajcakH-Index: 66
view all 5 authors...
BACKGROUND: Multiple studies have found a reduced reward positivity (RewP) among individuals with major depressive disorder (MDD). Event-related potential studies have also reported blunted neural responses to pleasant pictures in MDD as reflected by the late positive potential (LPP). These deficits have been interpreted broadly in terms of anhedonia and decreased emotional engagement characteristic of depression. METHODS: In the current study, a community-based sample of 83 participants with cu...
3 CitationsSource
#1Belel Ait Oumeziane (Purdue University)H-Index: 4
#2Olivia Jones (Purdue University)H-Index: 1
Last. Dan Foti (Purdue University)H-Index: 28
view all 3 authors...
Reward dysfunction is thought to be play a critical role in the pathogenesis of depression. Multiple studies have linked depression to abnormal neural sensitivity to monetary rewards, but it remains unclear whether this reward dysfunction is generalizable to other rewards types. The current study begins to address this gap by assessing abnormal sensitivity to both monetary and social rewards in relation to depressive symptoms. We recorded event-related potentials (ERPs) during two incentive dela...
1 CitationsSource
#1Judith K. Morgan (University of Pittsburgh)H-Index: 12
#2Jennifer S. Silk (University of Pittsburgh)H-Index: 39
Last. Erika E. Forbes (University of Pittsburgh)H-Index: 43
view all 4 authors...
Abstract Objective Children of depressed parents are at increased risk for psychopathology. One putative mechanism of risk appears to be altered processing of emotion-related stimuli. Although prior work has evaluated how adolescent offspring of depressed parents may show blunted reward processing compared to low-risk youth, there has been less attention to how young children with this familial history may differ from their peers during middle childhood, a period of critical socio-affective deve...
Source