Neuronal excitation/inhibition balance is set by the need for sleep and the biological clock

Animal [Vyazovskiy et al., 2011] and human [Huber et al., 2012] data indicate that neuronal excitability linearly increases with time awake. However, recent animal data posit that synaptic efficacy and morphology depend on time of day and on the biological clock [Liston et al., 2013]. Collectively, these data point to uncertainties about how brain dynamics are orchestrated by sleepand biological clock-dependent processes. Dynamic Causal...