Accelerated Brain Aging in Schizophrenia: A Longitudinal Pattern Recognition Study

Objective: Despite the multitude of longitudinal neuroimaging studies that have been published, a basic question on the progressive brain loss in schizophrenia remains unaddressed: Does it reflect accelerated aging of the brain, or is it caused by a fundamentally different process? The authors used support vector regression, a supervised machine learning technique, to address this question. Method: In a longitudinal sample of 341 schizophrenia...