Targeted and exome sequencing identified somatic mutations in hepatocellular carcinoma

Aim Genetic analysis has revealed a subset of recurrently mutated genes and aberrant cellular signaling pathways in hepatocellular carcinoma. To investigate genetic alterations and dysregulated pathways in hepatocellular carcinoma, we performed targeted sequencing and exome analysis using next‐generation sequencer. Methods We analyzed the somatic mutational profiles of 16 genes in primary hepatocellular carcinoma by targeted ultra‐deep...