Original paper
A cholesterol-lowering VLP vaccine that targets PCSK9
Abstract
Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secretory protein that controls cholesterol homeostasis by enhancing endosomal and lysosomal degradation of the low-density lipoprotein receptor (LDL-R). Mutations that cause increased activity of PCSK9 are associated with hypercholesterolemia, atherosclerosis and early cardiovascular disease (CVD), whereas individuals with loss-of-function mutations in PCSK9 are apparently healthy but...
Paper Details
Title
A cholesterol-lowering VLP vaccine that targets PCSK9
Published Date
Oct 1, 2015
Journal
Volume
33
Issue
43
Pages
5747 - 5755
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Notes
History