Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Abstract
Depression is associated with alterations in corticostriatal reward circuitry. One pathophysiological pathway that may drive these changes is inflammation. Biomarkers of inflammation (for example, cytokines and C-reactive protein (CRP)) are reliably elevated in depressed patients. Moreover, administration of inflammatory stimuli reduces neural activity and dopamine release in reward-related brain regions in association with reduced motivation...
Paper Details
Title
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Published Date
Nov 10, 2015
Journal
Volume
21
Issue
10
Pages
1358 - 1365
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