Differential Gene Regulation by PPAR Agonist and Constitutively Active PPAR 2

The PPAR is a key adipogenic determination factor. Ligands for PPAR such as antidiabetic thiazolidinedione (TZD) compounds are adipogenic, and many adipocyte genes that are activated by TZDs contain binding sites for PPAR. Like ligands for other nuclear receptors, TZDs can regulate genes positively or negatively. Here, we sought to understand the importance of positive regulation of gene expression by PPAR in adipogenesis. Fusion of the potent...