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Yong Li
University of Pennsylvania
AdipogenesisRegulation of gene expressionPeroxisome proliferator-activated receptorNuclear receptorTranscription factor
3Publications
3H-index
437Citations
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Publications 3
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#1Hong-Ping Guan (UPenn: University of Pennsylvania)H-Index: 5
#2Yong Li (UPenn: University of Pennsylvania)H-Index: 3
Last. Mitchell A. Lazar (UPenn: University of Pennsylvania)H-Index: 115
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Thiazolidinediones (TZDs) are effective therapies for type 2 diabetes, which has reached epidemic proportions in industrialized societies. TZD treatment reduces circulating free fatty acids (FFAs), which oppose insulin actions in skeletal muscle and other insulin target tissues. Here we report that TZDs, acting as ligands for the nuclear receptor peroxisome proliferator-activated receptor (PPAR)-γ, markedly induce adipocyte glycerol kinase (GyK) gene expression. This is surprising, as standard t...
324 CitationsSource
#1Yong Li (UPenn: University of Pennsylvania)H-Index: 3
#2Mitchell A. Lazar (UPenn: University of Pennsylvania)H-Index: 115
The PPARγ is a key adipogenic determination factor. Ligands for PPARγ such as antidiabetic thiazolidinedione (TZD) compounds are adipogenic, and many adipocyte genes that are activated by TZDs contain binding sites for PPARγ. Like ligands for other nuclear receptors, TZDs can regulate genes positively or negatively. Here, we sought to understand the importance of positive regulation of gene expression by PPARγ in adipogenesis. Fusion of the potent viral transcriptional activator VP16 to PPARγ2 (...
69 CitationsSource
The PPAR is a key adipogenic determination factor. Ligands for PPAR such as antidiabetic thiazolidinedione (TZD) compounds are adipogenic, and many adipocyte genes that are activated by TZDs contain binding sites for PPAR. Like ligands for other nuclear receptors, TZDs can regulate genes positively or negatively. Here, we sought to understand the importance of positive regulation of gene expression by PPAR in adipogenesis. Fusion of the potent viral transcriptional activator VP16 to PPAR2 (VP16-...
44 CitationsSource
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