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Molecular Endocrinology
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3 CitationsSource
#1Takuyu Hashiguchi (NIH: National Institutes of Health)H-Index: 2
#2Shingo Arakawa (NIH: National Institutes of Health)H-Index: 1
Last. Masahiko Negishi (NIH: National Institutes of Health)H-Index: 63
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Comparison of 11 human nuclear receptor amino acid sequences revealed a conserved phosphorylation motif within their DNA-binding domains as an intramolecular signal that regulates proteolytic degradation. Nuclear receptors use this signal to either degrade or proscribe degradation through either the proteasome or nonproteasome pathways. A phosphomimetic farnesoid X receptor (FXR) S154D mutant neither bound to nor trans-activated an FXR-response element-driven reporter gene and was rapidly degrad...
9 CitationsSource
#1Shaihla A. Khan (UW: University of Wyoming)H-Index: 2
#2Brian S. Edwards (UW: University of Wyoming)H-Index: 5
Last. Amy M. Navratil (UW: University of Wyoming)H-Index: 7
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Peptidylarginine deiminase (PAD) enzymes convert histone tail arginine residues to citrulline resulting in chromatin decondensation. Our previous work found that PAD isoforms are expressed in female reproductive tissues in an estrous cycle-dependent fashion, but their role in the anterior pituitary gland is unknown. Thus, we investigated PAD expression and function in gonadotrope cells. The gonadotrope-derived LβT2 cell line strongly expresses PAD2 at the protein level compared with other PAD is...
6 CitationsSource
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#1Vini Nagaraj (Lund University)H-Index: 5
#2Abdulla S. Kazim (Lund University)H-Index: 1
Last. Erik Renström (Lund University)H-Index: 47
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Elevated basal insulin secretion under fasting conditions together with insufficient stimulated insulin release is an important hallmark of type 2 diabetes, but the mechanisms controlling basal insulin secretion remain unclear. Membrane rafts exist in pancreatic islet cells and spatially organize membrane ion channels and proteins controlling exocytosis, which may contribute to the regulation of insulin secretion. Membrane rafts (cholesterol and sphingolipid containing microdomains) were dramati...
5 CitationsSource
#1Marjolein Droog (NKI-AVL: Netherlands Cancer Institute)H-Index: 8
#2Mark Mensink (NKI-AVL: Netherlands Cancer Institute)H-Index: 3
Last. Wilbert Zwart (NKI-AVL: Netherlands Cancer Institute)H-Index: 18
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Although many tissues express estrogen receptor (ER)α, most studies focus on breast cancer where ERα occupies just a small fraction of its total repertoire of potential DNA-binding sites, based on sequence. This raises the question: Can ERα occupy these other potential binding sites in a different context? Ligands, splice variants, posttranslational modifications, and acquired mutations of ERα affect its conformation, which may alter chromatin interactions. To date, literature describes the DNA-...
7 CitationsSource
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Endocrinology
Molecular biology
Receptor
Biochemistry
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