Original paper

Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan

Volume: 43, Issue: 3, Pages: 711 - 713
Published: Mar 1, 1999
Abstract
Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type inhA gene on a multicopy plasmid. Replacement of the mutant chromosomal inhA genes with wild-type inhA eliminated resistance. These results...
Paper Details
Title
Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan
Published Date
Mar 1, 1999
Volume
43
Issue
3
Pages
711 - 713
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