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Genetic evidence that InhA of Mycobacterium smegmatis is a target for triclosan.

Published on Mar 1, 1999in Antimicrobial Agents and Chemotherapy4.71
· DOI :10.1128/AAC.43.3.711
Laura M. McMurry24
Estimated H-index: 24
,
Patrick F. McDermott52
Estimated H-index: 52
,
Stuart B. Levy77
Estimated H-index: 77
(Tufts University)
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Abstract
Three Mycobacterium smegmatis mutants selected for resistance to triclosan each had a different mutation in InhA, an enoyl reductase involved in fatty acid synthesis. Two expressed some isoniazid resistance. A mutation originally selected on isoniazid also mediated triclosan resistance, as did the wild-type inhA gene on a multicopy plasmid. Replacement of the mutant chromosomal inhA genes with wild-type inhA eliminated resistance. These results suggest that M. smegmatis InhA, like its Escherichia coli homolog FabI, is a target for triclosan.
  • References (16)
  • Citations (168)
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References16
Newest
#1Richard J. Heath (St. Jude Children's Research Hospital)H-Index: 34
#2Yuen-Tsu Yu (St. Jude Children's Research Hospital)H-Index: 1
Last.Charles O. Rock (St. Jude Children's Research Hospital)H-Index: 26
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#1Laura M. McMurry (Tufts University)H-Index: 24
#2Margret Oethinger (Tufts University)H-Index: 11
Last.Stuart B. Levy (Tufts University)H-Index: 77
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#1Clair Baldock (University of Sheffield)H-Index: 27
#2John B. Rafferty (University of Sheffield)H-Index: 27
Last.David W. Rice (University of Sheffield)H-Index: 51
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#1Andréa Dessen (Albert Einstein College of Medicine)H-Index: 40
#2A. Quémard (Albert Einstein College of Medicine)H-Index: 1
Last.James C. Sacchettini (Albert Einstein College of Medicine)H-Index: 82
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#2Martin Krátký (Charles University in Prague)H-Index: 11
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#1Rachel H. McQueen (U of A: University of Alberta)H-Index: 8
#2Briana L. Ehnes (U of A: University of Alberta)H-Index: 1
#1Daniel J. Shaw (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 4
#2Kirsty Robb (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 5
Last.Paul A. Hoskisson (Strathclyde Institute of Pharmacy and Biomedical Sciences)H-Index: 20
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View next paperMolecular basis of triclosan activity.