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Beneficial effects of virgin coconut oil on lipid parameters and in vitro LDL oxidation

Published on Sep 1, 2004in Clinical Biochemistry 2.43
· DOI :10.1016/j.clinbiochem.2004.04.010
Kottayath Govindan Nevin3
Estimated H-index: 3
(UoK: University of Kerala),
Thankappan Rajamohan10
Estimated H-index: 10
(UoK: University of Kerala)
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Abstract
Objectives: The present study was conducted to investigate the effect of consumption of virgin coconut oil (VCO) on various lipid parameters in comparison with copra oil (CO). In addition, the preventive effect of polyphenol fraction (PF) from test oils on copper induced oxidation of LDL and carbonyl formation was also studied. Design and methods: After 45 days of oil feeding to Sprague–Dawley rats, several lipid parameters and lipoprotein levels were determined. PF was isolated from the oils and its effect on in vitro LDL oxidation was assessed. Results: VCO obtained by wet process has a beneficial effect in lowering lipid components compared to CO. It reduced total cholesterol, triglycerides, phospholipids, LDL, and VLDL cholesterol levels and increased HDL cholesterol in serum and tissues. The PF of virgin coconut oil was also found to be capable of preventing in vitro LDL oxidation with reduced carbonyl formation. Conclusion: The results demonstrated the potential beneficiary effect of virgin coconut oil in lowering lipid levels in serum and tissues and LDL oxidation by physiological oxidants. This property of VCO may be attributed to the biologically active polyphenol components present in the oil. D 2004 The Canadian Society of Clinical Chemists. All rights reserved.
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  • References (39)
  • Citations (188)
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References39
Newest
Published on Feb 1, 2003in Life Sciences 3.45
Stephanie A. Dillon2
Estimated H-index: 2
(LJMU: Liverpool John Moores University),
Rajpal S Burmi1
Estimated H-index: 1
(LJMU: Liverpool John Moores University)
+ 2 AuthorsKhalid Rahman32
Estimated H-index: 32
(LJMU: Liverpool John Moores University)
Abstract Oxidation of low-density lipoprotein (LDL) has been recognized as playing an important role in the development and progression of atherosclerotic heart disease. Human LDL was isolated and challenged with a range of oxidants either in the presence or absence of AGE or its diethyl ether extract. Oxidative modification of the LDL fraction using CuSO 4 , 5-lipoxygenase and xanthine/xanthine oxidase was monitored by both the appearance of thiobarbituric-acid substances (TBA-RS) and an increa...
Published on May 1, 2002in Journal of Medicinal Food 2.02
Nikolaos K. Andrikopoulos30
Estimated H-index: 30
,
Andriana C. Kaliora18
Estimated H-index: 18
+ 1 AuthorsVassilios P. Papageorgiou24
Estimated H-index: 24
The minor polyphenolic and nonpolyphenolic constituents of olive oil were examined, in various doses, against copper ion-induced low-density lipoprotein (LDL) oxidation and were found, in optimal doses (final concentration, 10 μM or 20 μM), to have remarkable biological activity, contributing to that previously reported for the major phenolic compounds. The main phytosterols, β-sitosterol, campesterol, and stigmasterol, were found to have 43.8%, 37.3%, and 33.4% LDL mean protection (MP) activity...
Published on Mar 1, 2002in Atherosclerosis 4.25
Jerzy-Roch Nofer28
Estimated H-index: 28
,
Beate E. Kehrel39
Estimated H-index: 39
+ 3 AuthorsA. von Eckardstein70
Estimated H-index: 70
Abstract The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol and the risk of coronary heart disease, the protection of susceptible animals from atherosclerosis by transgenic manipulation of HDL metabolism, and several potentially anti-atherogenic in vitro-properties have made HDL metabolism an interesting target for pharmacological intervention in atheroslcerosis. We have previously reviewed the concept of reverse cholesterol transport, which describes both...
Published on Jan 1, 2002in Free Radical Research 2.83
Teresa C.P. Dinis21
Estimated H-index: 21
,
Conceição L. Santos1
Estimated H-index: 1
,
Leonor M. Almeida31
Estimated H-index: 31
Peroxynitrite has been shown to modify low-density lipoproteins (LDL) into a form recognized by the macrophage scavenger receptor, suggesting that it may play a significant role in atherogenesis. Considering that the mechanisms underlying LDL modifications by this agent have not been well elucidated, the aim of this study was to characterize the chemical modifications of either the lipid or the protein moieties mediated by synthesized peroxynitrite (preformed) or formed in situ by SIN-1, and eva...
Published on Nov 1, 2001in Clinical Biochemistry 2.43
Eleni Bairaktari32
Estimated H-index: 32
(UoI: University of Ioannina),
Moses Elisaf61
Estimated H-index: 61
(UoI: University of Ioannina)
+ 4 AuthorsOrestes Tsolas22
Estimated H-index: 22
(UoI: University of Ioannina)
Abstract Objectives: Current recommendations for the management of dyslipidemia are largely based on the concentration of LDL-C. Most clinical laboratories estimate the concentration of LDL-C by the recommended routine method, the equation of Friedewald, in specimens from fasting subjects and with TG concentrations Design and Methods: In the present study we evaluated the accuracy of the following 5 different procedures for LDL-C in 98 patients on hemodialysis: the Friedewald equation, where LDL...
Published on Jul 1, 2001in Journal of Lipid Research 4.74
L. J. Schurgers1
Estimated H-index: 1
,
C. Vermeer1
Estimated H-index: 1
In this article we report the effects of low and high fat diets on the arterial thrombosis tendency in rats. The animal system used was the aorta loop model, in which we compared the effect of saturated (hardened coconut oil, HCO) and unsaturated (sunflower seed oil, SSO; corn oil, CO) fatty acids on the arterial thrombosis tendency at high fat intake (50 energy%, 45 energy% of which was either HCO, SSO, or CO). Under these conditions both SSO and CO had a beneficial effect (relative to HCO) on ...
Published on Jan 1, 2001in Arteriosclerosis, Thrombosis, and Vascular Biology 6.62
A. von Eckardstein70
Estimated H-index: 70
,
Jerzy-Roch Nofer28
Estimated H-index: 28
,
Gerd Assmann Frcp86
Estimated H-index: 86
Abstract —High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs. Enhancement of cholesterol efflux and of reverse cholesterol transport (RCT) is considered an important target for antiatherosclerotic drug therapy. Levels and composition of HDL subclasses in plas...
Published on Jun 1, 2000in West Indian Medical Journal 0.18
D. J. Pehowich1
Estimated H-index: 1
(U of A: University of Alberta),
Aldrin V Gomes1
Estimated H-index: 1
(U of A: University of Alberta),
J. A. Barnes1
Estimated H-index: 1
(U of A: University of Alberta)
The link between excessive consumption of dietary saturated fats and coronary heart disease (CHD) is now well established. Because of its high content of saturated fatty acids, the consumption of foods containing coconut oil may therefore be a risk factor for CHD. While the fatty acid composition of coconut oil is well established, relatively little is known about the other constituents of coconut: the milk, water, cream and meat fractions. In this study, we show that while the water fraction is...
Cited By188
Newest
Published on May 30, 2019in Neurogastroenterology and Motility 3.80
Paula Mosińska7
Estimated H-index: 7
(Medical University of Łódź),
Marta Martín-Ruiz1
Estimated H-index: 1
(UAM: Autonomous University of Madrid)
+ 8 AuthorsJakub Fichna26
Estimated H-index: 26
(Medical University of Łódź)
Sitti Rahmawati1
Estimated H-index: 1
(Tadulako University),
Siti Nuryanti1
Estimated H-index: 1
(Tadulako University),
Kasmir Sy. Male (Tadulako University)
Mohit D. Gupta10
Estimated H-index: 10
,
M.P. Girish5
Estimated H-index: 5
,
Rakesh Yadav12
Estimated H-index: 12
(AIIMS: All India Institute of Medical Sciences)
Published on Jul 1, 2019in Food Control 4.25
Nuwan Karunarathna1
Estimated H-index: 1
(University of Peradeniya),
Chandima J. Fernando (University of Peradeniya)+ 1 AuthorsRuchika Fernando1
Estimated H-index: 1
(University of Peradeniya)
Abstract Aflatoxin contamination in edible vegetable oils is a global concern due to the harmful effects of aflatoxins on human health. This study reports the status of aflatoxin contamination in seven edible vegetable oil types obtained from Sri Lankan market: coconut oil (n = 32), palm olein (n = 5), sunflower oil (n = 5), sesame oil (n = 5), olive oil (n = 5), soya bean oil (n = 4) and corn oil (n = 3). Coconut oil included locally produced branded products (n = 16) and unbranded products (n ...
Published on Jul 1, 2019in Nutrition Research 2.63
Sue Robinson5
Estimated H-index: 5
(Dal: Dalhousie University),
Myles William O'Brien2
Estimated H-index: 2
(Dal: Dalhousie University)
+ 2 AuthorsDerek S. Kimmerly7
Estimated H-index: 7
(Dal: Dalhousie University)
Abstract Virgin coconut oil (VCO) is high in antioxidants, which reduce reactive oxygen species–induced conversion of vascular endothelial-derived nitric oxide (NO) to toxic peroxynitrite. As such, flow-mediated dilation (FMD, a surrogate marker of NO bioavailability) and exercise-mediated hyperemia may be enhanced following VCO treatment. Animal research supports these findings, but direct assessments of FMD after short-term VCO use in humans are unknown. We tested the hypotheses that a 4-week ...
Published on Apr 22, 2019
Renan da Silva Lima (UFSC: Universidade Federal de Santa Catarina), Jane Mara Block11
Estimated H-index: 11
(UFSC: Universidade Federal de Santa Catarina)
Published on Jun 1, 2019in Aquaculture Nutrition 2.10
Andrews Apraku1
Estimated H-index: 1
(Shanghai Ocean University),
Xuxiong Huang (Shanghai Ocean University), Christian Larbi Ayisi (University for Development Studies)
Published on May 28, 2019in Molecules 3.06
Valeria De Matteis6
Estimated H-index: 6
,
Mariafrancesca Cascione7
Estimated H-index: 7
+ 2 AuthorsRosaria Rinaldi
Lauric acid is a green derivate that is abundant in some seeds such as coconut oil where it represents the most relevant fatty acid. Some studies have emphasized its anticancer effect due to apoptosis induction. In addition, the lauric acid is a Phase Change Material having a melting temperature of about 43.2 °C: this property makes it a powerful tool in cancer treatment by hyperthermal stress, generally induced at 43 °C. However, the direct use of lauric acid can have some controversial effects...