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Clinical Biochemistry
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2.43
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9573
Papers 9515
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#1Jesse C. Seegmiller (UMN: University of Minnesota)H-Index: 9
#2Kathy Larson (UMN: University of Minnesota)H-Index: 1
Last.Amy K. Saenger (UMN: University of Minnesota)H-Index: 19
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Abstract Background A laboratory investigation was initiated after a renal failure patient had a 2.18 mg/dL decrease in serum creatinine, which was not explained through medical intervention. The investigation revealed specimens providing questionably low results had been collected from a peripherally inserted central catheter (PICC) line. Methods Patient specimens and serum pools were analyzed by the Siemens Vista enzymatic creatinine measurement procedure. A simulation of the patient's infusio...
#1Óscar M. Peiró (URV: Rovira i Virgili University)
#2Á. García-OsunaH-Index: 1
Last.Alfredo Bardají (URV: Rovira i Virgili University)H-Index: 26
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Abstract Background Growth Differentiation Factor-15 (GDF-15) predicts death and cardiovascular events in acute coronary syndromes (ACS). We aimed to assess the long-term prognostic value of GDF-15 in ACS. Methods We included 358 patients with ACS who underwent coronary angiography. Plasma GDF-15 was measured and clinical data and long-term events were registered. Incremental value of GDF-15 for prognosing all-cause death above a clinical model including GRACE score, left ventricular ejection fr...
#2Victoria Higgins (U of T: University of Toronto)H-Index: 6
Last.Khosrow Adeli (U of T: University of Toronto)H-Index: 54
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Abstract Background Reference intervals have traditionally been partitioned by age based on statistical significance and physiological relevance. However, analyte concentration does not change abruptly with age, but rather dynamically. In this study, we establish biochemical marker continuous reference intervals for a Canadian population using healthy pediatric reference individuals and compare these to partitioned reference intervals. Methods Continuous reference intervals spanning 1–18.5 years...
#1Philip W. Connelly (St. Michael's Hospital)H-Index: 54
#2Andrew T. Yan (St. Michael's Hospital)H-Index: 31
Last.G. V. Ramesh Prasad (St. Michael's Hospital)H-Index: 25
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Abstract Background Growth differentiation factor 15 (GDF15) is markedly increased in end-stage kidney disease and has been related to increased mortality in patients on dialysis. We hypothesized that kidney transplantation would decrease both GDF15 and N-terminal pro-B-type natriuretic peptide (NT-proBNP) and that GDF-15 decrease relates to post-kidney transplantation allograft function. Methods End-stage kidney disease patients on dialysis awaiting a living donor kidney transplantation (n = 39...
#1Radoslav Matej (Charles University in Prague)H-Index: 11
#2Adam Tesar (First Faculty of Medicine, Charles University in Prague)
Last.Robert Rusina (Charles University in Prague)H-Index: 9
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Abstract Neuropathological diagnostic criteria of neurodegenerative disorders are based on the presence of specific inclusions in a specific area of brain tissue that correlate with clinical manifestations. Concomitant neurodegenerative disorders correspond to a combination of two (or more) different fully developed diseases in the same patient. Concomitant neurodegenerative pathology represents the presence of definite neurodegeneration and deposits of pathological proteins specific for another...
Abstract Background There is no worldwide recognized reference system and standard for urinary albumin measurement until now, so the analytical quality from different laboratories has always varied. In this study, we aimed to evaluate the analytical performance of a urinary albumin assay system using Sigma-metric, and thereby choose a suitable control rule to guarantee the analytical quality of the assays. Method Two levels of diluted reference material (ERM-DA47OK/IFCC) were used to calculate t...
#1Abdolkarim Mahrooz (Mazandaran University of Medical Sciences)H-Index: 6
#2Michael I. Mackness (University of Manchester)H-Index: 59
Last.Parisa Masoumi (Babol University of Medical Sciences)
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Abstract Background Paraoxonase 1 (PON1) is an important antiatherogenic and antioxidant enzyme in the circulation that has been associated with adverse health outcomes particularly cardiovascular disease (CVD) and other metabolic disorders. PON1 is a highly promiscuous enzyme and can hydrolyse a large variety of substrates, however, detailed structure/function studies have concluded that the natural substrates for PON1 are lipophilic lactones. The interindividual variability in PON1 activity ha...
#1Yoko Onizuka (RMIT: RMIT University)H-Index: 3
#2Kazue Nagai (RMIT: RMIT University)H-Index: 3
Last.Kunihiko Hayashi (RMIT: RMIT University)H-Index: 16
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Abstract Objective We aimed to establish correlations for the levels of follicle-stimulating hormone (FSH), estrone (E1) and estradiol (E2) between urine and serum in premenopausal and postmenopausal women using immunoassays. Methods In this study of 92 women (61 postmenopausal, 31 premenopausal), both urine and blood specimens were collected on the same day and stored at 4 °C for analysis by chemiluminescent immunoassay, radioimmunoassay and/or electrochemiluminescent immunoassay. Results There...
#1Ivan Zivotic (University of Belgrade)H-Index: 2
#2Tamara Djurić (University of Belgrade)H-Index: 9
Last.Maja Zivkovic (University of Belgrade)H-Index: 7
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Abstract Background Chromosomal region 9p21.3 is most robustly associated with coronary artery disease (CAD) in western European populations. However, heterogeneity in CAD phenotypes leads to uncertainty whether 9p21.3 is associated with stable and/or acute clinical presentations of CAD. 9p21.3 is rich in regulatory elements, but the underlying mechanisms of its actions in CAD remain unclear. We investigate the association of 9p21.3 two haplotype blocks lead variants (rs10757278 and rs518394) wi...
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