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The Shanghai Women's Health Study: Rationale, Study Design, and Baseline Characteristics

Published on Dec 1, 2005in American Journal of Epidemiology4.47
· DOI :10.1093/aje/kwi322
Wei Zheng110
Estimated H-index: 110
(Vandy: Vanderbilt University),
Wong Ho Chow77
Estimated H-index: 77
+ 9 AuthorsYing Gao93
Estimated H-index: 93
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Abstract
Although cancer is a major cause of morbidity and mortality in most nations, the spectrum of cancer occurrence varies substantially worldwide. Most previous epidemiologic studies investigating cancer etiology were conducted in North American and western European countries that are relatively homogenous in terms of cancer spectrums and many lifestyle exposures. These limitations may have hindered these studies from evaluating some important etiologic hypotheses. From 1996 to 2000, the Shanghai Women’s Health Study recruited 74,942 adult Chinese women from selected urban communities, with a 92% response rate. All participants completed a detailed baseline survey and anthropometrics. Approximately 88% of cohort members donated a urine sample (n ¼ 65,755) and a blood (n ¼ 56,832) or exfoliated buccal cell (n ¼ 8,934) sample. Noteworthy characteristics of this cohort include low consumption of alcohol (1.9%) and use of tobacco (2.4%); high intake of fish (mean, 50.8 g/day), soy foods (mean, 142.3 g/day), and certain vegetables; low prevalence of obesity (5.1%); and nearly 100% employment outside the home. Currently, this cohort of women is being followed via biennial in-person recontact and periodic linkage to cancer and vital statistics registries. The resources from the cohort will be valuable in future studies of environmental exposures and biomarkers for the risk of cancer and other chronic diseases. cohort studies; diet; neoplasms; nutrition; occupations
  • References (67)
  • Citations (293)
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References67
Newest
Published on Sep 12, 2005in JAMA Internal Medicine20.77
Xianglan Zhang25
Estimated H-index: 25
,
Xiao-Ou Shu96
Estimated H-index: 96
+ 4 AuthorsWei Zheng110
Estimated H-index: 110
Background: Soy consumption has been shown to modulate bone turnover and increase bone mineral density in postmenopausal women. To our knowledge, no published studies have directly examined the association between soy consumption and risk of fracture. Methods:We examined the relationship between usual soy food consumption and fracture incidence in 24403 postmenopausal women who had no history of fracture orcancerandwererecruitedbetweenMarch1,1997,and May 23, 2000, in the Shanghai Women’s Health ...
Published on May 1, 2005in Chinese journal of epidemiology
Gao J1
Estimated H-index: 1
,
Yong-Bing Xiang41
Estimated H-index: 41
+ 5 AuthorsGao Yt1
Estimated H-index: 1
Objective To assess the effect of tea consumption on the risk of endometrial cancer. Methods In a population based case-control study conducted in urban Shanghai, face-to-face interviews were completed for 995 incidence cases aged 30-69 from January 1997 to December 2002 and 1087 controls that frequency-matched to cases on age. Unconditional logistic model was used for analysis. Results An inverse association was observed in tea drinking and endometrial cancer risk. Compared to non-tea drinkers,...
Published on May 1, 2005in The American Journal of Clinical Nutrition6.57
Gong Yang53
Estimated H-index: 53
(VUMC: Vanderbilt University Medical Center),
Xiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)
+ 5 AuthorsWei Zheng110
Estimated H-index: 110
(VUMC: Vanderbilt University Medical Center)
Background: Several small-scale clinical trials have suggested a potential beneficial effect of short-term soy consumption on blood pressure (BP). Data are scanty on long-term effects of the usual intake of soy foods on BP in general populations. Objective: Our aim was to examine the association between usual intake of soy foods and BP. Design: The usual intake of soy foods was assessed at baseline, and BP was measured 2–3 y after the baseline survey among 45 694 participants of the Shanghai Wom...
Published on Feb 1, 2005in American Journal of Epidemiology4.47
Xianglan Zhang25
Estimated H-index: 25
,
Xiao-Ou Shu96
Estimated H-index: 96
+ 5 AuthorsWei Zheng110
Estimated H-index: 110
Abstract Growing evidence suggests that exposure to environmental tobacco smoke may have deleterious cardiovascular effects. Few studies have investigated environmental tobacco smoke exposure in relation to stroke. The authors examined the association between smoking by husbands and stroke prevalence among women nonsmokers in Shanghai, China, where two thirds of men but few women smoke. They analyzed baseline survey data (1997-2000) from a population-based cohort study, the Shanghai Women's Heal...
Published on Aug 1, 2004in Cancer Epidemiology, Biomarkers & Prevention5.06
Zefang Ren14
Estimated H-index: 14
,
Qiuyin Cai64
Estimated H-index: 64
+ 5 AuthorsWei Zheng110
Estimated H-index: 110
Cumulative evidence suggests that insulin-like growth factors (IGF) play an important role in the etiology of breast cancer. The IGF binding proteins regulate the action of IGFs, and >90% of circulating IGFs are bound to IGFBP-3. We evaluated the associations of five (A-202C, G227C, C3804G, 5606InsA, and C5827T) genetic polymorphisms in the IGFBP3 gene with breast cancer risk and the blood IGFBP-3 protein level in a population-based, case-control study conducted among Chinese women in Shanghai. ...
Published on Jul 7, 2004in Journal of the National Cancer Institute10.21
Eunyoung Cho49
Estimated H-index: 49
(Harvard University),
Stephanie A. Smith-Warner46
Estimated H-index: 46
(BU: Boston University)
+ 22 AuthorsEdward Giovannucci175
Estimated H-index: 175
(Harvard University)
Background: Studies in animals have suggested that calcium may reduce the risk of colorectal cancer. However, results from epidemiologic studies of intake of calcium or dairy foods and colorectal cancer risk have been inconclusive. Methods: We pooled the primary data from 10 cohort studies in five countries that assessed usual dietary intake by using a validated food frequency questionnaire at baseline. For most studies, follow-up was extended beyond that in the original publication. The studies...
Published on Jun 1, 2004in International Journal of Obesity4.51
Zhang X1
Estimated H-index: 1
,
Xiao-Ou Shu96
Estimated H-index: 96
+ 6 AuthorsZheng W1
Estimated H-index: 1
OBJECTIVE: To evaluate the associations of body size and fat distribution with incidence of coronary heart disease (CHD) in Chinese women. DESIGN: Population-based, prospective cohort study. SUBJECTS: A total of 67 334 women aged 40-70 y, who had no prior history of CHD, stroke, and cancer at study recruitment. MEASUREMENTS: Weight, standing and sitting heights, circumferences of waist and hip, and ratios of the anthropometric measurements. Outcome: incidence of CHD (non-fatal myocardial infarct...
Published on May 29, 2004in BMJ27.60
Wang Hong Xu14
Estimated H-index: 14
,
Wei Zheng110
Estimated H-index: 110
+ 5 AuthorsXiao-Ou Shu96
Estimated H-index: 96
Objective To evaluate the association of intake of soya food, a rich source of phytoestrogens, with the risk of endometrial cancer. Design Population based case-control study, with detailed information on usual soya food intake over the past five years collected by face to face interview using a food frequency questionnaire. Setting Urban Shanghai, China. Participants 832 incident cases of endometrial cancer in women aged of 30 to 69 years diagnosed during 1997-2001 and identified from the Shang...
Published on May 1, 2004in Cancer Epidemiology, Biomarkers & Prevention5.06
Wei Zheng110
Estimated H-index: 110
,
Ying Gao93
Estimated H-index: 93
+ 4 AuthorsJeffrey R. Smith32
Estimated H-index: 32
The CYP11A gene encodes the cholesterol side-chain cleavage enzyme (P450scc) that catalyzes the first and rate-limiting step for the biosynthesis of sex hormones. A pentanucleotide repeat [( TAAAA )n] polymorphism in the 5′ of the CYP11A gene has been reported to be related to the risk of polycystic ovary syndrome, an inherited endocrine disorder characterized by hyperandrogenemia. We investigated the association of this polymorphism with breast cancer risk in a population-based case-control stu...
Published on Apr 1, 2004in International Journal of Obesity4.51
Aron D. Rosenthal2
Estimated H-index: 2
(Vandy: Vanderbilt University),
FanJin46
Estimated H-index: 46
+ 8 AuthorsYing Gao93
Estimated H-index: 93
OBJECTIVE: To assess the relationship between measures of central and overall obesity and risk of diabetes. DESIGN: Nested case-control study. SETTING: Shanghai, China. PARTICIPANTS: A total of 57 130 women were screened for diabetes at enrollment for the Shanghai Women's Health Study (SWHS), a population-based cohort study of Chinese women aged 40-70 y. In this study, 345 women diagnosed with diabetes and 2760 age-matched controls (eight controls per case), randomly selected from women who test...
Cited By293
Newest
Published on Sep 20, 2019
Wei Jie Seow10
Estimated H-index: 10
(NUS: National University of Singapore),
Xiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)
+ 18 AuthorsSteven C. Moore39
Estimated H-index: 39
(NIH: National Institutes of Health)
Importance Chinese women have the highest rate of lung cancer among female never-smokers in the world, and the etiology is poorly understood. Objective To assess the association between metabolomics and lung cancer risk among never-smoking women. Design, Setting, and Participants This nested case-control study included 275 never-smoking female patients with lung cancer and 289 never-smoking cancer-free control participants from the prospective Shanghai Women’s Health Study recruited from Decembe...
Published on 2019in International Journal of Cancer4.98
Natalie Pritchett2
Estimated H-index: 2
(NIH: National Institutes of Health),
Marlena Maziarz8
Estimated H-index: 8
(NIH: National Institutes of Health)
+ 7 AuthorsYou-Lin Qiao59
Estimated H-index: 59
(Academy of Medical Sciences, United Kingdom)
Published on May 7, 2019in American Journal of Epidemiology4.47
Yong Cui15
Estimated H-index: 15
(VUMC: Vanderbilt University Medical Center),
Wanqing Wen51
Estimated H-index: 51
(VUMC: Vanderbilt University Medical Center)
+ 9 AuthorsMingrong You (VUMC: Vanderbilt University Medical Center)
Published on Jul 23, 2019in Atmosphere2.05
H. Dean Hosgood52
Estimated H-index: 52
,
Madelyn Klugman1
Estimated H-index: 1
+ 32 AuthorsRezaMalekzadeh78
Estimated H-index: 78
Household air pollution (HAP) is of public health concern, with ~3 billion people worldwide (including >15 million in the US) exposed. HAP from coal use is a human lung carcinogen, yet the epidemiological evidence on carcinogenicity of HAP from biomass use, primarily wood, is not conclusive. To robustly assess biomass’s carcinogenic potential, prospective studies of individuals experiencing a variety of HAP exposures are needed. We have built a global consortium of 13 prospective cohorts (HAPCO:...
Published on Jul 9, 2019in European Journal of Preventive Cardiology5.64
Na Liu1
Estimated H-index: 1
(HUST: Huazhong University of Science and Technology),
Jae Jeong Yang (VUMC: Vanderbilt University Medical Center)+ 11 AuthorsXiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)
BackgroundThe recent American College of Cardiology/American Heart Association guidelines for high blood pressure lowered the hypertension criteria from systolic/diastolic blood pressure (SBP/DBP) ...
Published on Jun 15, 2019in International Journal of Epidemiology7.34
Sang Nguyen (Vandy: Vanderbilt University), Honglan Li2
Estimated H-index: 2
(SJTU: Shanghai Jiao Tong University)
+ 6 AuthorsXiao-Ou Shu96
Estimated H-index: 96
(Vandy: Vanderbilt University)
Published on Jun 1, 2019in Clinical Nutrition6.40
Long-Gang Zhao5
Estimated H-index: 5
(SJTU: Shanghai Jiao Tong University),
Xiao-Ou Shu96
Estimated H-index: 96
(Vandy: Vanderbilt University)
+ 7 AuthorsWei Zheng110
Estimated H-index: 110
(Vandy: Vanderbilt University)
Summary Background & aims Vitamin B6 has been postulated to play an important role in determining chronic diseases. However, few studies have evaluated associations between dietary vitamin B6 and cause-specific mortality comprehensively. Methods We investigated the associations between vitamin B6 from diet and risk of all-cause, and cause-specific mortality in 134,480 participants from the Shanghai Men's Health Study (2002–2014) and Shanghai Women's Health Study (1997–2014). The median follow-up...
Published on Jun 1, 2019in JNCI Cancer Spectrum
Neil S Zheng2
Estimated H-index: 2
(Yale University),
Evelyn Hsieh7
Estimated H-index: 7
(Yale University)
+ 5 AuthorsXiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)
Published on May 9, 2019in International Journal of Cancer4.98
Bryan A. Bassig19
Estimated H-index: 19
(HHS: United States Department of Health and Human Services),
Xiao-Ou Shu96
Estimated H-index: 96
(Vandy: Vanderbilt University)
+ 22 AuthorsLawrence S. Engel24
Estimated H-index: 24
(UNC: University of North Carolina at Chapel Hill)
Published on Feb 1, 2019in International Journal of Urology2.11
Xiang Shu1
Estimated H-index: 1
(VUMC: Vanderbilt University Medical Center),
Hui Cai46
Estimated H-index: 46
(VUMC: Vanderbilt University Medical Center)
+ 6 AuthorsXiao-Ou Shu96
Estimated H-index: 96
(VUMC: Vanderbilt University Medical Center)