Albumin Binding of Acylated Insulin (NN304) Does Not Deter Action to Stimulate Glucose Uptake

NN304 [LysB29-tetradecanoyl des(B30) human insulin] is a potentially therapeutic insulin analog designed to exhibit protracted glucose-lowering action. In dogs with infusion rates similar to insulin itself, NN304 exhibits similar glucose uptake (Rd) stimulation with delayed onset of action. This compartmental modeling study was to determine if NN304 action could be accounted for by the ∼2% unbound NN304 concentration. NN304 (or human insulin) (n...