Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
Marianthe Hamilton-Wessler
University of Southern California
13Publications
11H-index
802Citations
Publications 13
Newest
Published on Jun 1, 2006in Diabetes 7.20
Martin Ellmerer25
Estimated H-index: 25
,
Marianthe Hamilton-Wessler11
Estimated H-index: 11
+ 5 AuthorsRichard N. Bergman103
Estimated H-index: 103
Physiological hyperinsulinemia provokes hemodynamic actions and augments access of macromolecules to insulin-sensitive tissues. We investigated whether induction of insulin resistance by a hypercaloric high-fat diet has an effect on the extracellular distribution of macromolecules to insulin-sensitive tissues. Male mongrel dogs were randomly selected into two groups: seven dogs were fed an isocaloric control diet (∼3,900 kcal, 35% from fat), and six dogs were fed a hypercaloric high-fat diet (∼5...
36 Citations Source Cite
Published on Nov 1, 2004in Diabetes 7.20
Martin Ellmerer25
Estimated H-index: 25
,
Stella P. Kim17
Estimated H-index: 17
+ 3 AuthorsRichard N. Bergman103
Estimated H-index: 103
Pharmacological doses of insulin increase limb blood flow and enhance tissue recruitment for small solutes such as glucose. We investigated whether elevating insulin within the physiological range (68 ± 6 vs. 425 ± 27 pmol/l) can influence tissue recruitment of [ 14 C]inulin, an inert diffusionary marker of molecular weight similar to that of insulin itself. During hyperinsulinemic-euglycemic clamps, transport parameters and distribution volumes of [ 14 C]inulin were determined in conscious dogs...
13 Citations Source Cite
Published on May 1, 2003in The Journal of Clinical Endocrinology and Metabolism 5.61
Martin Ellmerer25
Estimated H-index: 25
(SC: University of Southern California),
Marianthe Hamilton-Wessler11
Estimated H-index: 11
(SC: University of Southern California)
+ 5 AuthorsRichard N. Bergman103
Estimated H-index: 103
(SC: University of Southern California)
We compared metabolic effects as well as plasma and interstital fluid kinetics of fatty acid-acylated insulin, LysB29(Ne-ω-carboxynonadecanoyl)-des(B30) human insulin (O346), with previously determined kinetics of native insulin and insulin detemir. Euglycemic clamps with iv injection of O346 (90 pmol/kg) or saline control were performed in 10 male mongrel dogs under inhalent anesthesia. The t1/2 for the clearance of O346 from plasma was 375.7 ± 26.7 min; the t1/2 for the appearance of O346 in i...
3 Citations Source Cite
Published on Jan 15, 2003in Journal of Clinical Investigation 12.28
Katrin Hücking12
Estimated H-index: 12
,
Marianthe Hamilton-Wessler11
Estimated H-index: 11
+ 1 AuthorsRichard N. Bergman103
Estimated H-index: 103
Rapid oscillations of visceral lipolysis have been reported. To examine the putative role of the CNS in oscillatory lipolysis, we tested the effects of β3-blockade on pulsatile release of FFAs. Arterial blood samples were drawn at 1-minute intervals for 120 minutes from fasted, conscious dogs (n = 7) during the infusion of saline or bupranolol (1.5 μg/kg/min), a high-affinity β3-blocker. FFA and glycerol time series were analyzed and deconvolution analysis was applied to estimate the rate of FFA...
63 Citations Source Cite
Published on Mar 1, 2002in Diabetes 7.20
Melvin K. Dea9
Estimated H-index: 9
,
Marianthe Hamilton-Wessler11
Estimated H-index: 11
+ 5 AuthorsRichard N. Bergman103
Estimated H-index: 103
NN304 [Lys B29 -tetradecanoyl des(B30) human insulin] is a potentially therapeutic insulin analog designed to exhibit protracted glucose-lowering action. In dogs with infusion rates similar to insulin itself, NN304 exhibits similar glucose uptake ( R d ) stimulation with delayed onset of action. This compartmental modeling study was to determine if NN304 action could be accounted for by the ∼2% unbound NN304 concentration. NN304 (or human insulin) ( n = 6 each) was infused at 10.2 pmol · min −1 ...
63 Citations Source Cite
Published on Mar 1, 2002in Diabetes 7.20
Marianthe Hamilton-Wessler11
Estimated H-index: 11
,
Marilyn Ader28
Estimated H-index: 28
+ 4 AuthorsRichard N. Bergman103
Estimated H-index: 103
A defect in transcapillary transport of insulin in skeletal muscle and adipose tissue has been proposed to play a role in the insulin resistance that leads to type 2 diabetes, yet the mechanism of insulin transfer across the capillary endothelium from plasma to interstitium continues to be debated. This study examined in vivo the interstitial appearance of insulin in hindlimb using the fatty acid acylated insulin analog Lys B29 -tetradecanoyl des-(B30) human insulin, or NN304, as a marker for in...
41 Citations Source Cite
Published on Jan 1, 2001in Journal of Investigative Medicine 1.99
Richard N. Bergman103
Estimated H-index: 103
(SC: University of Southern California),
Gregg W. Van Citters8
Estimated H-index: 8
(SC: University of Southern California)
+ 4 AuthorsMartin Ellmerer25
Estimated H-index: 25
(SC: University of Southern California)
Abstract Insulin resistance is associated with a plethora of chronic illnesses, including Type 2 diabetes, dyslipidemia, clotting dysfunction, and colon cancer. The relationship between obesity and insulin resistance is well established, and an increase in obesity in Western countries is implicated in increased incidence of diabetes and other diseases. Central, or visceral, adiposity has been particularly associated with insulin resistance; however, the mechanisms responsible for this associatio...
176 Citations Source Cite
Published on Dec 1, 2000in Diabetes 7.20
Steven D. Mittelman29
Estimated H-index: 29
,
G W Van Citters2
Estimated H-index: 2
+ 4 AuthorsRichard N. Bergman103
Estimated H-index: 103
Central adiposity is highly correlated with insulin resistance, which is an important risk factor for type 2 diabetes and other chronic diseases. However, in normal individuals, central adiposity can be tolerated for many years without development of impaired glucose tolerance or diabetes. Here we examine longitudinally the mechanisms by which glucose tolerance can be maintained in the face of substantial insulin resistance. Normal dogs were fed a diet enriched with moderate amounts of fat (2 g ...
164 Citations Source Cite
Published on Oct 1, 1999in Diabetologia 7.11
Marianthe Hamilton-Wessler11
Estimated H-index: 11
(SC: University of Southern California),
Marilyn Ader28
Estimated H-index: 28
(SC: University of Southern California)
+ 4 AuthorsRichard N. Bergman103
Estimated H-index: 103
(SC: University of Southern California)
Aims/hypothesis. The provision of stable, reproducible basal insulin is crucial to diabetes management. This study in dogs examined the metabolic effects and interstitial fluid (ISF) profiles of fatty acid acylated insulin, LysB29-tetradecanoyl, des-(B30) human insulin (NN304). Methods. Euglycaemic clamps were carried out under inhalant anaesthesia during equimolar intravenous infusions (3.6 pmol · min–1· kg–1 for 480 min) of human insulin or NN304 (n = 8 per group). Results. Steady-state total ...
69 Citations Source Cite
Published on Dec 1, 1998in Diabetes 7.20
Lisa Getty3
Estimated H-index: 3
,
Marianthe Hamilton-Wessler11
Estimated H-index: 11
+ 2 AuthorsRichard N. Bergman103
Estimated H-index: 103
We examined the hindlimb lymph insulin profile during simulated intravenous glucose tolerance tests (IVGTTs) in anesthetized dogs to test the following hypotheses: 1) the biphasic insulin response to intravenous glucose can be seen as a priming bolus and a secondary infusion that effect a rapid stepwise increase in the interstitial insulin concentration and 2) the activation of glucose utilization (rate of glucose uptake [Rd]) during an IVGTT is more similar to the dynamics of the interstitial i...
38 Citations Source Cite
12