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Melvin K. Dea
University of Southern California
14Publications
9H-index
914Citations
Publications 14
Newest
#1Deborah A. PodolinH-Index: 16
#2Yuren WeiH-Index: 22
Last.Jillian E. AdamsH-Index: 2
view all 25 authors...
#1Rahul N. Khurana (SC: University of Southern California)H-Index: 13
#2Thomas A. Albini (SC: University of Southern California)H-Index: 27
Last.Jennifer I. Lim (SC: University of Southern California)H-Index: 21
view all 5 authors...
Purpose To report an atypical presentation of multiple evanescent white dot syndrome (MEWDS). Design Observational case report. Methods Review of the clinical, laboratory, photographic, and angiographic records of a patient with MEWDS. Results A 29-year-old woman presented with 20/400 vision in the right eye associated with multiple, granular lesions of varying sizes (100–1000 μm) in the outer retina, a prominent panuveitis, diffuse choroidal thickening and enlarged blindspot. The multiple lesio...
5 CitationsSource
#1Morvarid Kabir (SC: University of Southern California)H-Index: 14
#2Karyn J. Catalano (SC: University of Southern California)H-Index: 11
Last.Richard N. Bergman (SC: University of Southern California)H-Index: 96
view all 7 authors...
The mechanism by which increased central adiposity causes hepatic insulin resistance is unclear. The “portal hypothesis” implicates increased lipolytic activity in the visceral fat and therefore increased delivery of free fatty acids (FFA) to the liver, ultimately leading to liver insulin resistance. To test the portal hypothesis at the transcriptional level, we studied expression of several genes involved in glucose and lipid metabolism in the fat-fed dog model with visceral adiposity vs. contr...
249 CitationsSource
#1Martin Ellmerer (SC: University of Southern California)H-Index: 3
#2Marianthe Hamilton-Wessler (SC: University of Southern California)H-Index: 11
Last.Richard N. Bergman (SC: University of Southern California)H-Index: 96
view all 8 authors...
We compared metabolic effects as well as plasma and interstital fluid kinetics of fatty acid-acylated insulin, LysB29(Ne-ω-carboxynonadecanoyl)-des(B30) human insulin (O346), with previously determined kinetics of native insulin and insulin detemir. Euglycemic clamps with iv injection of O346 (90 pmol/kg) or saline control were performed in 10 male mongrel dogs under inhalent anesthesia. The t1/2 for the clearance of O346 from plasma was 375.7 ± 26.7 min; the t1/2 for the appearance of O346 in i...
3 CitationsSource
#1Gregg W. Van Citters (SC: University of Southern California)H-Index: 8
#2Morvarid Kabir (SC: University of Southern California)H-Index: 14
Last.Richard N. Bergman (SC: University of Southern California)H-Index: 96
view all 7 authors...
We previously developed a canine model of central obesity and insulin resistance by supplementing the normal chow diet with 2 g cooked bacon grease/kg body weight. Dogs fed this fatty diet maintained glucose tolerance with compensatory hyperinsulinemia. The signal(s) responsible for this up-regulation of plasma insulin is unknown. We hypothesized that meal-derived factors such as glucose, fatty acids, or incretin hormones may signal β-cell compensation in the fat-fed dog. We fed the same fat-sup...
33 CitationsSource
#1Melvin K. DeaH-Index: 9
Last.Richard N. BergmanH-Index: 96
view all 8 authors...
NN304 [Lys B29 -tetradecanoyl des(B30) human insulin] is a potentially therapeutic insulin analog designed to exhibit protracted glucose-lowering action. In dogs with infusion rates similar to insulin itself, NN304 exhibits similar glucose uptake ( R d ) stimulation with delayed onset of action. This compartmental modeling study was to determine if NN304 action could be accounted for by the ∼2% unbound NN304 concentration. NN304 (or human insulin) ( n = 6 each) was infused at 10.2 pmol · min −1 ...
67 CitationsSource
#2Marilyn AderH-Index: 28
Last.Richard N. BergmanH-Index: 96
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A defect in transcapillary transport of insulin in skeletal muscle and adipose tissue has been proposed to play a role in the insulin resistance that leads to type 2 diabetes, yet the mechanism of insulin transfer across the capillary endothelium from plasma to interstitium continues to be debated. This study examined in vivo the interstitial appearance of insulin in hindlimb using the fatty acid acylated insulin analog Lys B29 -tetradecanoyl des-(B30) human insulin, or NN304, as a marker for in...
43 CitationsSource
#1K. Fosgerau (Novo Nordisk)H-Index: 1
#2Steven D. Mittelman (SC: University of Southern California)H-Index: 30
Last.Richard N. Bergman (SC: University of Southern California)H-Index: 96
view all 6 authors...
It has been proposed that the glycogenolytic and gluconeogenic pathways contributing to endogenous glucose production are interrelated. Thus a change in one source of glucose 6-phosphate might be c...
9 CitationsSource
#1Richard N. Bergman (SC: University of Southern California)H-Index: 96
#2Gregg W. Van Citters (SC: University of Southern California)H-Index: 8
Last.Martin Ellmerer (SC: University of Southern California)H-Index: 3
view all 7 authors...
Abstract Insulin resistance is associated with a plethora of chronic illnesses, including Type 2 diabetes, dyslipidemia, clotting dysfunction, and colon cancer. The relationship between obesity and insulin resistance is well established, and an increase in obesity in Western countries is implicated in increased incidence of diabetes and other diseases. Central, or visceral, adiposity has been particularly associated with insulin resistance; however, the mechanisms responsible for this associatio...
178 CitationsSource
#1Steven D. MittelmanH-Index: 30
#2G W Van CittersH-Index: 2
Last.Richard N. BergmanH-Index: 96
view all 7 authors...
Central adiposity is highly correlated with insulin resistance, which is an important risk factor for type 2 diabetes and other chronic diseases. However, in normal individuals, central adiposity can be tolerated for many years without development of impaired glucose tolerance or diabetes. Here we examine longitudinally the mechanisms by which glucose tolerance can be maintained in the face of substantial insulin resistance. Normal dogs were fed a diet enriched with moderate amounts of fat (2 g ...
168 CitationsSource
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