HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
Volume: 28, Issue: 24, Pages: 2712 - 2725
Published: Dec 15, 2014
Abstract
Cellular senescence is a stable proliferation arrest that suppresses tumorigenesis. Cellular senescence and associated tumor suppression depend on control of chromatin. Histone chaperone HIRA deposits variant histone H3.3 and histone H4 into chromatin in a DNA replication-independent manner. Appropriately for a DNA replication-independent chaperone, HIRA is involved in control of chromatin in nonproliferating senescent cells, although its role...
Paper Details
Title
HIRA orchestrates a dynamic chromatin landscape in senescence and is required for suppression of neoplasia
Published Date
Dec 15, 2014
Volume
28
Issue
24
Pages
2712 - 2725
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