Peter D. Adams
University of Glasgow
Molecular biologySenescenceGeneticsBiologyCell biology
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Publications 130
#2Jaideep Kapur (UVA: University of Virginia)H-Index: 36
Last. Daniel H. Lowenstein (UCSF: University of California, San Francisco)H-Index: 70
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Summary Background Benzodiazepine-refractory, or established, status epilepticus is thought to be of similar pathophysiology in children and adults, but differences in underlying aetiology and pharmacodynamics might differentially affect response to therapy. In the Established Status Epilepticus Treatment Trial (ESETT) we compared the efficacy and safety of levetiracetam, fosphenytoin, and valproate in established status epilepticus, and here we describe our results after extending enrolment in ...
1 CitationsSource
#2Tianhui LiuH-Index: 1
Last. Xue LeiH-Index: 1
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Cellular senescence is a potent tumor suppressor mechanism but also contributes to aging and aging-related diseases. Senescence is characterized by a stable cell cycle arrest and a complex proinflammatory secretome, termed the senescence-associated secretory phenotype (SASP). We recently discovered that cytoplasmic chromatin fragments (CCFs), extruded from the nucleus of senescent cells, trigger the SASP through activation of the innate immunity cytosolic DNA sensing cGAS-STING pathway. However,...
2 CitationsSource
#1Douglas J. MacKenzie (Glas.: University of Glasgow)H-Index: 2
#2Neil A. Robertson (Glas.: University of Glasgow)H-Index: 7
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 11 authors...
Summary Approximately 10% of human colorectal cancer (CRC) are associated with activated BRAFV600E mutation, typically in absence of APC mutation and often associated with a CpG Island Methylator (CIMP) phenotype. To protect from cancer, normal intestinal epithelial cells respond to oncogenic BRAFV600E by activation of intrinsic p53 and p16-dependent tumor suppressor mechanisms, such as cellular senescence. Conversely, CIMP is thought to contribute to bypass of these tumor suppressor mechanisms,...
#1Stella Victorelli (Newcastle University)H-Index: 4
#2Anthony Lagnado (Newcastle University)H-Index: 3
Last. João F. Passos (Newcastle University)H-Index: 29
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1 CitationsSource
#1Christopher G. Bell (QMUL: Queen Mary University of London)H-Index: 23
#2Robert Lowe (QMUL: Queen Mary University of London)H-Index: 17
Last. Vardhman K. Rakyan (QMUL: Queen Mary University of London)H-Index: 34
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Epigenetic clocks comprise a set of CpG sites whose DNA methylation levels measure subject age. These clocks are acknowledged as a highly accurate molecular correlate of chronological age in humans and other vertebrates. Also, extensive research is aimed at their potential to quantify biological aging rates and test longevity or rejuvenating interventions. Here, we discuss key challenges to understand clock mechanisms and biomarker utility. This requires dissecting the drivers and regulators of ...
9 CitationsSource
#2Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
Last. Marco Demaria (UMCG: University Medical Center Groningen)H-Index: 26
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Cellular senescence is a cell state implicated in various physiological processes and a wide spectrum of age-related diseases. Recently, interest in therapeutically targeting senescence to improve healthy aging and age-related disease, otherwise known as senotherapy, has been growing rapidly. Thus, the accurate detection of senescent cells, especially in vivo, is essential. Here, we present a consensus from the International Cell Senescence Association (ICSA), defining and discussing key cellula...
19 CitationsSource
#1Tânia D. F. Costa (KI: Karolinska Institutet)H-Index: 2
#2Ting Zhuang (KI: Karolinska Institutet)H-Index: 4
Last. Staffan Strömblad (KI: Karolinska Institutet)H-Index: 30
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Overcoming cellular growth restriction, including the evasion of cellular senescence, is a hallmark of cancer. We report that PAK4 is overexpressed in all human breast cancer subtypes and associated with poor patient outcome. In mice, MMTV-PAK4 overexpression promotes spontaneous mammary cancer, while PAK4 gene depletion delays MMTV-PyMT driven tumors. Importantly, PAK4 prevents senescence-like growth arrest in breast cancer cells in vitro, in vivo and ex vivo, but is not needed in non-immortali...
3 CitationsSource
AbstractIntroductionThe PAMPer trial demonstrated a 30-day survival benefit among hypotensive trauma patients treated with prehospital plasma during air medical transport. We characterized resources, costs and feasibility of air medical prehospital plasma program implementation.MethodsWe performed a
#1Yee Voan Teo (Brown University)H-Index: 3
#2Nattaphong Rattanavirotkul (Edin.: University of Edinburgh)H-Index: 1
Last. Tamir Chandra (Edin.: University of Edinburgh)H-Index: 17
view all 15 authors...
Summary Oncogene-induced senescence (OIS) is a tumor suppressive response to oncogene activation that can be transmitted to neighboring cells through secreted factors of the senescence-associated secretory phenotype (SASP). Currently, primary and secondary senescent cells are not considered functionally distinct endpoints. Using single-cell analysis, we observed two distinct transcriptional endpoints, a primary endpoint marked by Ras and a secondary endpoint marked by Notch activation. We find t...
#1Nikki K. Lytle (UCSD: University of California, San Diego)H-Index: 9
#2L. Paige Ferguson (UCSD: University of California, San Diego)H-Index: 1
Last. Tannishtha ReyaH-Index: 32
view all 33 authors...
Summary Drug resistance and relapse remain key challenges in pancreatic cancer. Here, we have used RNA sequencing (RNA-seq), chromatin immunoprecipitation (ChIP)-seq, and genome-wide CRISPR analysis to map the molecular dependencies of pancreatic cancer stem cells, highly therapy-resistant cells that preferentially drive tumorigenesis and progression. This integrated genomic approach revealed an unexpected utilization of immuno-regulatory signals by pancreatic cancer epithelial cells. In particu...
7 CitationsSource