Match!
John J. Cole
University of Glasgow
Regulation of gene expressionDNA methylationEpigeneticsGeneticsBiology
18Publications
7H-index
333Citations
What is this?
Publications 19
Newest
#1Katja Thümmler (Glas.: University of Glasgow)H-Index: 3
#2Eran RomH-Index: 11
Last. Christopher Linington (Glas.: University of Glasgow)H-Index: 59
view all 12 authors...
Fibroblast growth factor (FGF) signaling contributes to failure of remyelination in multiple sclerosis, but targeting this therapeutically is complicated by its functional pleiotropy. We now identify FGF2 as a factor up-regulated by astrocytes in active inflammatory lesions that disrupts myelination via FGF receptor 2 (FGFR2) mediated activation of Wingless (Wnt) signaling; pharmacological inhibition of Wnt being sufficient to abrogate inhibition of myelination by FGF2 in tissue culture. Using a...
Source
#1Emma L. Smith (Glas.: University of Glasgow)H-Index: 1
#2D Somma (Glas.: University of Glasgow)
Last. Ruaidhrí J. Carmody (Glas.: University of Glasgow)H-Index: 22
view all 9 authors...
Phosphorylation of the NF-κB transcription factor is an important regulatory mechanism for the control of transcription. Here we identify serine 80 (S80) as a phosphorylation site on the p50 subunit of NF-κB, and IKKβ as a p50 kinase. Transcriptomic analysis of cells expressing a p50 S80A mutant reveals a critical role for S80 in selectively regulating the TNFα inducible expression of a subset of NF-κB target genes including pro-inflammatory cytokines and chemokines. S80 phosphorylation regulate...
Source
#1Lewis C. Rodgers (Discovery Centre)
#2John J. Cole (Discovery Centre)H-Index: 7
Last. Carl S. Goodyear (Discovery Centre)H-Index: 28
view all 7 authors...
Objectives: Fatty acid oxidation (FAO) and glycolysis have been implicated in immune regulation and activation of macrophages. However, investigation of human monocyte intracellular metabolism in the context of the hypoxic and inflammatory rheumatoid arthritis (RA) synovium is lacking. We hypothesized that exposure of monocytes to the hypoxic and inflammatory RA environment would have a profound impact on their metabolic state, and potential to contribute to disease pathology. Methods: Human mon...
Source
#1Lc Rodgers (Discovery Centre)
#2John J. Cole (Discovery Centre)H-Index: 7
Last. Carl S. Goodyear (Discovery Centre)H-Index: 28
view all 7 authors...
Career situation of first and presenting author Post-doctoral fellow. Introduction Metabolic pathways are considered to have a governing role in inflammatory cascades in myeloid cells. This is particularly evident in murine macrophages where glycolysis and fatty acid oxidation (FAO) have been implicated in inflammatory cascades and immune regulation respectively. 1 However, investigation of intracellular metabolism of human monocytes in the context of the hypoxic and inflammatory RA synovium is ...
Source
#1Taranjit Singh Rai (Glas.: University of Glasgow)H-Index: 18
#2Mandy Glass (Glas.: University of Glasgow)H-Index: 7
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 10 authors...
The HIRA histone chaperone complex deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independent manner. As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex affects herpesvirus infection. After infection of primary cells with HSV or CMV, or transient transfection with naked plasmid DNA, HIRA re-localizes to PML bodies, sites of cellular anti-viral activity. HIRA co-localizes with viral genomes, binds to incoming viral and pla...
5 CitationsSource
#1John van Tuyn (Glas.: University of Glasgow)H-Index: 18
#2Farah Jaber-Hijazi (Glas.: University of Glasgow)H-Index: 5
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 14 authors...
On acquisition of an oncogenic mutation, primary human and mouse cells can enter oncogene-induced senescence (OIS). OIS is characterized by a stable proliferation arrest and secretion of proinflammatory cytokines and chemokines, the senescence-associated secretory phenotype. Proliferation arrest and the senescence-associated secretory phenotype collaborate to enact tumor suppression, the former by blocking cell proliferation and the latter by recruiting immune cells to clear damaged cells. Howev...
7 CitationsSource
#1John J. Cole (Glas.: University of Glasgow)H-Index: 7
#2Neil A. Robertson (Glas.: University of Glasgow)H-Index: 7
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 14 authors...
Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging “clock”, a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill this knowledge gap, we defined age-associated DNA methylation changes at the whole-genome, single-nucleotide level in mouse liver and tested the impact of longevity-promoting interventions, spec...
50 CitationsSource
#1David M. Nelson (Glas.: University of Glasgow)H-Index: 9
#2Farah Jaber-Hijazi (Glas.: University of Glasgow)H-Index: 5
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 23 authors...
Background Histone modification H4K20me3 and its methyltransferase SUV420H2 have been implicated in suppression of tumorigenesis. The underlying mechanism is unclear, although H4K20me3 abundance increases during cellular senescence, a stable proliferation arrest and tumor suppressor process, triggered by diverse molecular cues, including activated oncogenes. Here, we investigate the function of H4K20me3 in senescence and tumor suppression.
12 CitationsSource
#1Clara Correia-Melo (Newcastle University)H-Index: 8
#2Francisco D.M. Marques (Newcastle University)H-Index: 3
Last. João F. Passos (Newcastle University)H-Index: 29
view all 28 authors...
Abstract Cell senescence is an important tumour suppressor mechanism and driver of ageing. Both functions are dependent on the development of the senescent phenotype, which involves an overproduction of pro‐inflammatory and pro‐oxidant signals. However, the exact mechanisms regulating these phenotypes remain poorly understood. Here, we show the critical role of mitochondria in cellular senescence. In multiple models of senescence, absence of mitochondria reduced a spectrum of senescence effector...
150 CitationsSource
#1Anne-Louise Latif (Glas.: University of Glasgow)H-Index: 1
#2John J. Cole (Glas.: University of Glasgow)H-Index: 7
Last. Peter D. Adams (Glas.: University of Glasgow)H-Index: 43
view all 10 authors...
Background: There remains a critical requirement for novel therapies for Acute Myeloid Leukemia (AML). Bromodomain and extra-terminal domain (BET) inhibitors are emerging as exciting therapeutic agents for hematopoietic malignancies. Pharmacological inhibition of BET bromodomains targets malignant cells by preventing reading of acetylated lysine residues, thus disrupting chromatin-mediated signal transduction, which reduces transcription at oncogenic loci. Although a heterogeneous disease, most ...
2 CitationsSource
12