Original paper
CCR5 Deficiency Aggravates Crescentic Glomerulonephritis in Mice
Abstract
The chemokine receptor CCR5 is predominantly expressed on monocytes and Th1-polarized T cells, and plays an important role in T cell and monocyte recruitment in inflammatory diseases. To investigate the functional role of CCR5 in renal inflammation, we induced a T cell-dependent model of glomerulonephritis (nephrotoxic serum nephritis) in CCR5(-/-) mice. Induction of nephritis in wild-type mice resulted in up-regulation of renal mRNA expression...
Paper Details
Title
CCR5 Deficiency Aggravates Crescentic Glomerulonephritis in Mice
Published Date
Nov 1, 2008
Journal
Volume
181
Issue
9
Pages
6546 - 6556
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Notes
History