Original paper
Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection
Abstract
Mutation rate varies greatly between nucleotide sites of the human genome and depends both on the global genomic location and the local sequence context of a site. In particular, CpG context elevates the mutation rate by an order of magnitude. Mutations also vary widely in their effect on the molecular function, phenotype, and fitness. Independence of the probability of occurrence of a new mutation's effect has been a fundamental premise in...
Paper Details
Title
Hypermutable Non-Synonymous Sites Are under Stronger Negative Selection
Published Date
Nov 28, 2008
Journal
Volume
4
Issue
11
Pages
e1000281 - e1000281
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Notes
History