E Protein Function in Lymphocyte Development
Abstract
Lymphocytes arise from hematopoietic stem cells through the coordinated action of transcription factors. The E proteins (E12, E47, HEB and E2-2) have emerged as key regulators of both B and T lymphocyte differentiation. This review summarizes the current data and examines the various functions of E proteins and their antagonists, Id2 and Id3, throughout lymphoid maturation. Beyond an established role in B and T lineage commitment, E proteins...
Paper Details
Title
E Protein Function in Lymphocyte Development
Published Date
Apr 1, 2002
Journal
Volume
20
Issue
1
Pages
301 - 322
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