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Cornelis Murre
University of California, San Diego
Molecular biologyGeneticsTranscription factorBiologyCell biology
147Publications
65H-index
16.1kCitations
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Publications 210
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#1Nadia S Kurd (UCSD: University of California, San Diego)
#2Zhaoren He (UCSD: University of California, San Diego)H-Index: 2
Last. Jocelyn G. Olvera (UCSD: University of California, San Diego)H-Index: 2
view all 18 authors...
During an immune response to microbial infection, CD8+ T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subset of noncirculating tissue-resident memory (TRM) cells that mediate potent protection within nonlymphoid tissues. Here, we used single-cell RNA sequencing to examine the gene expression patterns of individual CD8+ T cells in the spleen and small intestine intra...
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#1Alexandra Bortnick (UCSD: University of California, San Diego)H-Index: 2
#2Z He (UCSD: University of California, San Diego)H-Index: 1
Last. Cornelis Murre (UCSD: University of California, San Diego)H-Index: 65
view all 8 authors...
The transition from the follicular B to the plasma cell stage is associated with large-scale changes in cell morphology. Here, we examine whether plasma cell development is also associated with changes in nuclear architecture. We find that the onset of plasma cell development is concomitant with a decline in remote genomic interactions; a gain in euchromatic character at loci encoding for factors that specify plasma cell fate, including Prdm1 and Atf4; and establishment of de novo inter-chromoso...
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#1Nadia S Kurd (UCSD: University of California, San Diego)
#2Zhaoren He (UCSD: University of California, San Diego)H-Index: 2
Last. Tiffani Tysl (UCSD: University of California, San Diego)H-Index: 2
view all 17 authors...
During an immune response to microbial infection, CD8+ T cells give rise to distinct classes of cellular progeny that coordinately mediate clearance of the pathogen and provide long-lasting protection against reinfection, including a subset of non-circulating tissue-resident memory (TRM) cells that mediate potent protection within non-lymphoid tissues. Here, we utilized single-cell RNA-sequencing to examine the gene expression patterns of individual CD8+ T cells in the spleen and small intestine...
1 CitationsSource
#1Matthew DenholtzH-Index: 9
#2Yina ZhuH-Index: 2
Last. Cornelis MurreH-Index: 65
view all 8 authors...
Differentiating neutrophils undergo large-scale changes in nuclear morphology. How such alterations in structure are established and modulated upon exposure to microbial agents is largely unknown. Here, we found that prior to encounter with bacteria, an armamentarium of inflammatory genes was positioned in a transcriptionally passive environment suppressing premature transcriptional activation. Upon microbial exposure, however, human neutrophils rapidly (<3 h) repositioned the ensemble of proinf...
2 CitationsSource
#1Matthew Denholtz (University of California, Berkeley)
#2Yina Zhu (University of California, Berkeley)
Last. Cornelis Murre (University of California, Berkeley)H-Index: 2
view all 8 authors...
Differentiating neutrophils undergo large-scale changes in nuclear morphology. How such alterations in structure are established and modulated upon exposure to microbial agents is largely unknown. Here, we found that prior to encounter with bacteria, an armamentarium of inflammatory genes was positioned in a transcriptionally passive environment suppressing premature transcriptional activation. Upon microbial exposure, however, human neutrophils rapidly (<3 hours) repositioned the ensemble of pr...
Source
#1Huizhong Xu (Salk Institute for Biological Studies)H-Index: 1
#2Zhisong Tong (Salk Institute for Biological Studies)H-Index: 9
Last. Hu Cang (Salk Institute for Biological Studies)H-Index: 25
view all 18 authors...
During prophase I of meiosis, chromosomes become organized as loop arrays around the proteinaceous chromosome axis. As homologous chromosomes physically pair and recombine, the chromosome axis is integrated into the tripartite synaptonemal complex (SC) as this structure’s lateral elements (LEs). While the components of the mammalian chromosome axis/LE—including meiosis-specific cohesin complexes, the axial element proteins SYCP3 and SYCP2, and the HORMA domain proteins HORMAD1 and HORMAD2—are kn...
3 CitationsSource
#1Nimish Khanna (UCSD: University of California, San Diego)H-Index: 4
#2Yaojun Zhang (Princeton University)H-Index: 8
Last. Cornelis Murre (UCSD: University of California, San Diego)H-Index: 65
view all 5 authors...
Diverse antibody repertoires are generated through remote genomic interactions involving immunoglobulin variable (VH), diversity (DH) and joining (JH) gene segments. How such interactions are orchestrated remains unknown. Here we develop a strategy to track VH-DHJH motion in B-lymphocytes. We find that VH and DHJH segments are trapped in configurations that allow only local motion, such that spatially proximal segments remain in proximity, while spatially remote segments remain remote. Within a ...
3 CitationsSource
#1Tessa Arends (University of Colorado Denver)H-Index: 3
#2Carissa Dege (University of Colorado Denver)H-Index: 3
Last. James Hagman (University of Colorado Denver)H-Index: 24
view all 15 authors...
Cell lineage specification is a tightly regulated process that is dependent on appropriate expression of lineage and developmental stage-specific transcriptional programs. Here, we show that Chromodomain Helicase DNA-binding protein 4 (CHD4), a major ATPase/helicase subunit of Nucleosome Remodeling and Deacetylase Complexes (NuRD) in lymphocytes, is essential for specification of the early B cell lineage transcriptional program. In the absence of CHD4 in B cell progenitors in vivo, development o...
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#1E. Mauricio Barajas-Mora (Scripps Research Institute)H-Index: 2
#2Eden Kleiman (Scripps Research Institute)H-Index: 2
Last. Ann J. Feeney (Scripps Research Institute)H-Index: 34
view all 8 authors...
Summary The genome is organized into topologically associated domains (TADs) that enclose smaller subTADs. Here, we identify and characterize an enhancer that is located in the middle of the V gene region of the immunoglobulin kappa light chain (Igκ) locus that becomes active preceding the stage at which this locus undergoes V(D)J recombination. This enhancer is a hub of long-range chromatin interactions connecting subTADs in the V gene region with the recombination center at the J genes. Deleti...
4 CitationsSource
#1Cornelis Murre (UCSD: University of California, San Diego)H-Index: 65
6 CitationsSource
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