Structure-Based Identification of Aporphines with Selective 5-HT_2AReceptor-Binding Activity

Selective blockade of the serotonin 5‐HT 2A receptor is a useful therapeutic approach for a number of disorders, including schizophrenia, insomnia and ischaemic heart disease. A series of aporphines were docked into a homology model of the rat 5‐HT 2A receptor using AutoDock. Selected compounds with high in silico binding affinities were screened in vitro using radioligand‐binding assays against rat serotonin (5‐HT 1A and 5‐HT 2A ) and dopamine...