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trans Palmitoleic acid arises endogenously from dietary vaccenic acid

Published on Mar 1, 2014in The American Journal of Clinical Nutrition6.57
· DOI :10.3945/ajcn.113.076117
Anke Jaudszus8
Estimated H-index: 8
(FSU: University of Jena),
Ronny Kramer8
Estimated H-index: 8
(FSU: University of Jena)
+ 3 AuthorsKatrin Kuhnt12
Estimated H-index: 12
(FSU: University of Jena)
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Abstract
Background: trans Palmitoleic acid (t-16:1n–7, or 16:1t 9i n thed nomenclature usually applied to trans fatty acids and used herein) arouses great scientific interest because it has been suggested to serve as a biomarker for lower risks of type 2 diabetes and coronary artery disease. Objective: Although 16:1t9 has been assumed to derive from dietary sources, we examined the hypothesis that 16:1t9 might also be endogenously produced from its metabolic precursor vaccenic acid (t-18:1n–7 or 18:1t11). Design: We reevaluated fatty acid data obtained from one human intervention study and one cellular model in both of which 18:1t11 was supplemented. Both studies have already been published, but to our knowledge, 16:1t9 has not yet been considered. This reanalysis of the datasets was reasonable because a new methodology for identifying 16:1 cis and trans isomers allowed us to address the subject presented in this article. Results: Data showed that the systemic or intracellular increase in 16:1t9 was strongly correlated with the increase in 18:1t11 after the dietary intake or cellular uptake of 18:1t11. The conversion rate in humans was, on average, 17%. Conclusion: Our findings suggest that endogenous 16:1t 9i s not, as has been assumed, exclusively diet derived but may also be produced by the partial b oxidation of dietary 18:1t11. Am J Clin Nutr doi: 10. 3945/ajcn.113.076117.
  • References (20)
  • Citations (30)
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References20
Newest
#1Xiao-Ru Liu (NCU: Nanchang University)H-Index: 5
#2Ze-Yuan Deng (NCU: Nanchang University)H-Index: 6
Last.Wei-Feng Li (NCU: Nanchang University)H-Index: 1
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#1Anke Jaudszus (FSU: University of Jena)H-Index: 8
#2Gerhard Jahreis (FSU: University of Jena)H-Index: 37
Last.Dagmar Barz (Schiller International University)H-Index: 22
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#1Mélanie Plourde (Université de Sherbrooke)H-Index: 20
#2Raphaël Chouinard-Watkins (Université de Sherbrooke)H-Index: 10
Last.Stephen C. Cunnane (Université de Sherbrooke)H-Index: 40
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#1Dariush Mozaffarian (Harvard University)H-Index: 113
#2Haiming Cao (NIH: National Institutes of Health)H-Index: 12
Last.Gökhan S. Hotamisligil (Harvard University)H-Index: 99
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#2Vanina Bongard (University of Toulouse)
Last.J. L. Sébédio (INRA: Institut national de la recherche agronomique)H-Index: 29
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#1Ilse G. Pranger (UMCG: University Medical Center Groningen)H-Index: 2
#2E va Corpeleijn (UMCG: University Medical Center Groningen)H-Index: 28
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#1Farkas Sarnyai (Semmelweis University)
#2Mária Berinkeiné Donkó (BME: Budapest University of Technology and Economics)
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#1Linda H. MüngerH-Index: 4
#2Mar Garcia-Aloy (University of Barcelona)H-Index: 13
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#1Ilse G. Pranger (UMCG: University Medical Center Groningen)H-Index: 2
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