Original paper
Nuclear Reorganization of Mammalian DNA Synthesis Prior to Cell Cycle Exit
Abstract
In primary mammalian cells, DNA replication initiates in a small number of perinucleolar, lamin A/C-associated foci. During S-phase progression in proliferating cells, replication foci distribute to hundreds of sites throughout the nucleus. In contrast, we find that the limited perinucleolar replication sites persist throughout S phase as cells prepare to exit the cell cycle in response to contact inhibition, serum starvation, or replicative...
Paper Details
Title
Nuclear Reorganization of Mammalian DNA Synthesis Prior to Cell Cycle Exit
Published Date
Jan 1, 2004
Volume
24
Issue
2
Pages
595 - 607
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Notes
History