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Molecular and Cellular Biology
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#1Kang LiuH-Index: 11
#2Joshua D. GravesH-Index: 3
Last.Weei-Chin LinH-Index: 21
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#1Jannatul FerdoushH-Index: 3
#2Rwik SenH-Index: 7
Last.Sukesh R. BhaumikH-Index: 25
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Oxidation of a highly-conserved cysteine (Cys) residue located in the kinase-activation loop of mitogen-activated protein kinase kinases (MAPKK) inactivates mammalian MKK6. This residue is conserved in the fission yeast MAPKK Wis1, which belongs to the H2O2-responsive MAPK Sty1 pathway. Here, we show that H2O2 reversibly inactivates Wis1 through this residue (C458) in vitro. We found that C458 is oxidized in vivo and that serine substitution of this residue significantly enhances Wis1 activation...
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#1Gergely NagyH-Index: 10
#2Bence DanielH-Index: 10
Last.Laszlo NagyH-Index: 50
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#1Eric C. TomH-Index: 1
#2Insha MushtaqH-Index: 1
Last.Hamid BandH-Index: 49
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#1Xiaoxue LiH-Index: 1
#2Lan XiaoH-Index: 26
Last.Jian-Ying WangH-Index: 36
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