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Brian K. Kennedy
Buck Institute for Research on Aging
LongevitySaccharomyces cerevisiaeGeneticsBiologyCell biology
219Publications
66H-index
17.1kCitations
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Publications 210
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#1Gavin Yong Quan Ng (NUS: National University of Singapore)H-Index: 3
#2Dominic Paul Lee Kok Sheng (Genome Institute of Singapore)
Last. Vardan T. Karamyan (TTUHSC: Texas Tech University Health Sciences Center)H-Index: 17
view all 23 authors...
Intermittent fasting (IF) is a lifestyle intervention comprising a dietary regimen in which energy intake is restricted via alternating periods of fasting and ad libitum food consumption, without compromising nutritional composition. While epigenetic modifications can mediate effects of environmental factors on gene expression, no information is yet available on potential effects of IF on the epigenome. In this study, we found that IF causes modulation of histone H3 lysine 9 trimethylation (H3K9...
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#1Katherine H. Schreiber (Buck Institute for Research on Aging)H-Index: 6
#2Sebastian I. Arriola Apelo (UW: University of Wisconsin-Madison)H-Index: 6
Last. Dudley W. LammingH-Index: 34
view all 16 authors...
Rapamycin, an inhibitor of mechanistic Target Of Rapamycin Complex 1 (mTORC1), extends lifespan and shows strong potential for the treatment of age-related diseases. However, rapamycin exerts metabolic and immunological side effects mediated by off-target inhibition of a second mTOR-containing complex, mTOR complex 2. Here, we report the identification of DL001, a FKBP12-dependent rapamycin analog 40x more selective for mTORC1 than rapamycin. DL001 inhibits mTORC1 in cell culture lines and in vi...
6 CitationsSource
#1Jin Young Lee (Buck Institute for Research on Aging)H-Index: 1
#2Brian K. KennedyH-Index: 66
Last. Chen-Yu Liao (Buck Institute for Research on Aging)H-Index: 12
view all 3 authors...
1 CitationsSource
#1Matthew M. Crane (UW: University of Washington)H-Index: 13
#2Mitsuhiro Tsuchiya (UW: University of Washington)H-Index: 14
Last. Matt Kaeberlein (UW: University of Washington)H-Index: 55
view all 24 authors...
Abstract An increase in cell size with age is a characteristic feature of replicative aging in budding yeast. Deletion of the gene encoding Whi5 results in shortened duration of G1 and reduced cell size, and has been previously suggested to increase replicative lifespan. Upon careful analysis of multiple independently derived haploid and homozygous diploid whi5Δ mutants, we find no effect on lifespan, but we do confirm the reduction in cell size. We suggest that instead of antagonizing lifespan,...
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#1Brian K. Kennedy (Buck Institute for Research on Aging)H-Index: 66
#2Shih-Yin Tsai (NUS: National University of Singapore)
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#1Gregory M. Solis (Scripps Research Institute)H-Index: 7
#2Rozina Kardakaris (Scripps Research Institute)H-Index: 2
Last. Michael Petrascheck (Scripps Research Institute)H-Index: 14
view all 11 authors...
7 CitationsSource
#1Gregory M. Solis (Scripps Research Institute)H-Index: 7
#2Rozina Kardakaris (Scripps Research Institute)H-Index: 2
Last. Michael Petrascheck (Scripps Research Institute)H-Index: 14
view all 11 authors...
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#1Gregory M. Solis (Scripps Research Institute)H-Index: 7
#2Rozina Kardakaris (Scripps Research Institute)H-Index: 2
Last. Michael Petrascheck (Scripps Research Institute)H-Index: 14
view all 11 authors...
Aging impairs the activation of Stress Signaling Pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficient C. elegans by targeting cytoplasmic ribosomes, preferentially attenuating translation of highly translated mRNAs. In contrast to most other longevity paradigms, minocycline inhibits rather than activates all major SSPs and extends lifespan in mutan...
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#1Jane E.B. Reusch (University of Colorado Denver)H-Index: 44
#2T Rajendra Kumar (University of Colorado Denver)H-Index: 9
Last. Phil Zeitler (CU: University of Colorado Boulder)H-Index: 1
view all 39 authors...
2 CitationsSource
#1Samantha Haller (Genentech)H-Index: 1
#2Subir Kapuria (Buck Institute for Research on Aging)H-Index: 1
Last. Heinrich Jasper (Genentech)H-Index: 17
view all 13 authors...
Summary The balance between self-renewal and differentiation ensures long-term maintenance of stem cell (SC) pools in regenerating epithelial tissues. This balance is challenged during periods of high regenerative pressure and is often compromised in aged animals. Here, we show that target of rapamycin (TOR) signaling is a key regulator of SC loss during repeated regenerative episodes. In response to regenerative stimuli, SCs in the intestinal epithelium of the fly and in the tracheal epithelium...
21 CitationsSource
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