Original paper
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.
Abstract
Central adiposity is highly correlated with insulin resistance, which is an important risk factor for type 2 diabetes and other chronic diseases. However, in normal individuals, central adiposity can be tolerated for many years without development of impaired glucose tolerance or diabetes. Here we examine longitudinally the mechanisms by which glucose tolerance can be maintained in the face of substantial insulin resistance. Normal dogs were fed...
Paper Details
Title
Longitudinal compensation for fat-induced insulin resistance includes reduced insulin clearance and enhanced beta-cell response.
Published Date
Dec 1, 2000
Journal
Volume
49
Issue
12
Pages
2116 - 2125
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Notes
History