Match!
Steven D. Mittelman
University of Southern California
94Publications
30H-index
3,105Citations
Publications 95
Newest
#1Nicole M. Mueske (Children's Hospital Los Angeles)H-Index: 7
#2Steven D. Mittelman (SC: University of Southern California)H-Index: 30
Last.Etan Orgel (SC: University of Southern California)H-Index: 12
view all 5 authors...
AbstractMyosteatosis refers to fat deposition within muscle and is linked to risk of cardiovascular disease and metabolic disorders. Though these comorbidities are common during and after therapy f...
Source
#1F. M. Oliveira (UnB: University of Brasília)H-Index: 3
#2W. H. Tran (SC: University of Southern California)H-Index: 4
Last.Michael C. K. Khoo (SC: University of Southern California)H-Index: 25
view all 8 authors...
Current evidence in adults suggests that, independent of obesity, obstructive sleep apnea (OSA) can lead to autonomic dysfunction and impaired glucose metabolism, but these relationships are less clear in children. The purpose of this study was to investigate the associations among OSA, glucose metabolism, and daytime autonomic function in obese pediatric subjects. Twenty-three obese boys participated in: overnight polysomnography; a frequently sampled intravenous glucose tolerance test; and rec...
1 CitationsSource
#1Alaina P. Vidmar (SC: University of Southern California)H-Index: 1
#2R. PretlowH-Index: 1
Last.Steven D. Mittelman (SC: University of Southern California)H-Index: 30
view all 7 authors...
3 CitationsSource
#1Jonathan Tucci (SC: University of Southern California)H-Index: 5
#2Waseem Alhushki (SC: University of Southern California)H-Index: 1
Last.Steven D. Mittelman (SC: University of Southern California)H-Index: 30
view all 6 authors...
It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. Diet-induced obese (DIO) mice raised on a 60% calories from fat diet and control mice were implanted with syngeneic ALL ...
2 CitationsSource
#1Steven D. MittelmanH-Index: 30
#2Etan OrgelH-Index: 12
2 CitationsSource
#1Saskia Prasca (Children's Hospital Los Angeles)
#2Roxana Carmona (Children's Hospital Los Angeles)H-Index: 2
Last.Etan Orgel (SC: University of Southern California)H-Index: 12
view all 9 authors...
Abstract Introduction Acute lymphoblastic leukemia (ALL) therapy confers risk for venous thromboembolism (VTE) and associated acute and long-term morbidity. Obesity increases VTE risk in the general population but its impact on ALL therapy-associated VTE is unknown. Methods In a retrospective cohort of children treated for ALL between 2008 and 2016 (n = 294), we analyzed obesity at diagnosis (body mass index [BMI] ≥95%) and subsequent development of VTE. A subset participated in two concurrent p...
Source
#1Christina M. Dieli-Conwright (SC: University of Southern California)H-Index: 14
#2Jean-Hugues Parmentier (SC: University of Southern California)H-Index: 3
Last.Steven D. Mittelman (SC: University of Southern California)H-Index: 30
view all 8 authors...
Purpose Obesity is a leading modifiable contributor to breast cancer mortality due to its association with increased recurrence and decreased overall survival rate. Obesity stimulates cancer progression through chronic, low-grade inflammation in white adipose tissue, leading to accumulation of adipose tissue macrophages (ATMs), in particular, the pro-inflammatory M1 phenotype macrophage. Exercise has been shown to reduce M1 ATMs and increase the more anti-inflammatory M2 ATMs in obese adults. Th...
7 CitationsSource
#1Etan Orgel (SC: University of Southern California)H-Index: 12
#2Nicole M. Mueske (Children's Hospital Los Angeles)H-Index: 7
Last.Steven D. Mittelman (SC: University of Southern California)H-Index: 30
view all 6 authors...
AbstractObesity as defined by body mass index percentile (BMI%) is strongly associated with relapse and poorer survival in childhood ALL. Whether BMI% accurately reflects body fat percentage (BF%) in this population is unknown. We conducted a prospective study assessing body composition during frontline ALL therapy. Dual-energy X-ray absorptiometry measured BF% and lean muscle mass (LMM) at diagnosis, end of Induction, and end of Delayed Intensification. Sarcopenic obesity (gain in BF% with loss...
19 CitationsSource
#1Maristella Maggi (UNIPV: University of Pavia)H-Index: 7
#2Steven D. Mittelman (Children's Hospital Los Angeles)H-Index: 30
Last.Claudia Scotti (UNIPV: University of Pavia)H-Index: 10
view all 9 authors...
L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) and Erwinia chrysanthemi (ErAII) type II ASNases currently used in the clinics are characterized by high in vivo instability, short half-life and the requirement of several administrations to obtain a pharmacologically active concentration. Moreover, they are sensitive to proteases (cathepsin B and asparagine endopepti...
8 CitationsSource
#1Maristella MaggiH-Index: 7
#2Steven D. MittelmanH-Index: 30
Last.Claudia ScottiH-Index: 10
view all 6 authors...
Source
12345678910