Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!
Steven D. Mittelman
Children's Hospital Los Angeles
92Publications
29H-index
2,977Citations
Publications 92
Newest
Published on Jul 2, 2019in Leukemia & Lymphoma 2.67
Nicole M. Mueske6
Estimated H-index: 6
(Children's Hospital Los Angeles),
Steven D. Mittelman29
Estimated H-index: 29
(SC: University of Southern California)
+ 2 AuthorsEtan Orgel11
Estimated H-index: 11
(SC: University of Southern California)
AbstractMyosteatosis refers to fat deposition within muscle and is linked to risk of cardiovascular disease and metabolic disorders. Though these comorbidities are common during and after therapy for acute lymphoblastic leukemia (ALL), little is known about tissue distribution, including myosteatosis, in this population. Using quantitative computed tomography, we assessed the impact of ALL therapy on bone, muscle, subcutaneous, and muscle-associated (MA) fat in 12 adolescents and young adults (A...
Source Cite
Published on May 1, 2019in Pediatric Research 2.88
Flavia M. G. S. Oliveira2
Estimated H-index: 2
(UnB: University of Brasília),
Winston H. Tran3
Estimated H-index: 3
(SC: University of Southern California)
+ 5 AuthorsMichael C. K. Khoo25
Estimated H-index: 25
(SC: University of Southern California)
Current evidence in adults suggests that, independent of obesity, obstructive sleep apnea (OSA) can lead to autonomic dysfunction and impaired glucose metabolism, but these relationships are less clear in children. The purpose of this study was to investigate the associations among OSA, glucose metabolism, and daytime autonomic function in obese pediatric subjects. Twenty-three obese boys participated in: overnight polysomnography; a frequently sampled intravenous glucose tolerance test; and rec...
1 Citations Source Cite
Published on Feb 1, 2019in Pediatric Obesity 3.71
Alaina P. Vidmar1
Estimated H-index: 1
(SC: University of Southern California),
R. Pretlow1
Estimated H-index: 1
+ 4 AuthorsSteven D. Mittelman29
Estimated H-index: 29
(SC: University of Southern California)
2 Citations Source Cite
Published on Dec 1, 2018in Cancer and Metabolism
Jonathan Tucci5
Estimated H-index: 5
(SC: University of Southern California),
Waseem Alhushki1
Estimated H-index: 1
(SC: University of Southern California)
+ 3 AuthorsSteven D. Mittelman29
Estimated H-index: 29
(SC: University of Southern California)
Background It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL.
1 Citations Source Cite
Published on May 1, 2018in Thrombosis Research 3.27
Saskia Prasca (Children's Hospital Los Angeles), Roxana Carmona2
Estimated H-index: 2
(Children's Hospital Los Angeles)
+ 6 AuthorsEtan Orgel11
Estimated H-index: 11
(SC: University of Southern California)
Abstract Introduction Acute lymphoblastic leukemia (ALL) therapy confers risk for venous thromboembolism (VTE) and associated acute and long-term morbidity. Obesity increases VTE risk in the general population but its impact on ALL therapy-associated VTE is unknown. Methods In a retrospective cohort of children treated for ALL between 2008 and 2016 ( n = 294), we analyzed obesity at diagnosis (body mass index [BMI] ≥95%) and subsequent development of VTE. A subset participated in two concurrent ...
Source Cite
Published on Feb 1, 2018in Breast Cancer Research and Treatment 3.47
Christina M. Dieli-Conwright14
Estimated H-index: 14
(SC: University of Southern California),
Jean-Hugues Parmentier1
Estimated H-index: 1
(SC: University of Southern California)
+ 5 AuthorsSteven D. Mittelman29
Estimated H-index: 29
(SC: University of Southern California)
Purpose Obesity is a leading modifiable contributor to breast cancer mortality due to its association with increased recurrence and decreased overall survival rate. Obesity stimulates cancer progression through chronic, low-grade inflammation in white adipose tissue, leading to accumulation of adipose tissue macrophages (ATMs), in particular, the pro-inflammatory M1 phenotype macrophage. Exercise has been shown to reduce M1 ATMs and increase the more anti-inflammatory M2 ATMs in obese adults. Th...
5 Citations Source Cite
Published on Jan 2, 2018in Leukemia & Lymphoma 2.67
Etan Orgel11
Estimated H-index: 11
(SC: University of Southern California),
Nicole M. Mueske6
Estimated H-index: 6
(Children's Hospital Los Angeles)
+ 3 AuthorsSteven D. Mittelman29
Estimated H-index: 29
(SC: University of Southern California)
AbstractObesity as defined by body mass index percentile (BMI%) is strongly associated with relapse and poorer survival in childhood ALL. Whether BMI% accurately reflects body fat percentage (BF%) in this population is unknown. We conducted a prospective study assessing body composition during frontline ALL therapy. Dual-energy X-ray absorptiometry measured BF% and lean muscle mass (LMM) at diagnosis, end of Induction, and end of Delayed Intensification. Sarcopenic obesity (gain in BF% with loss...
13 Citations Source Cite
Published on Dec 1, 2017in Scientific Reports 4.01
Maristella Maggi6
Estimated H-index: 6
(UNIPV: University of Pavia),
Steven D. Mittelman29
Estimated H-index: 29
(Children's Hospital Los Angeles)
+ 6 AuthorsClaudia Scotti10
Estimated H-index: 10
(UNIPV: University of Pavia)
L-Asparaginases (ASNases) have been used as first line drugs for paediatric Acute Lymphoblastic Leukaemia (ALL) treatment for more than 40 years. Both the Escherichia coli (EcAII) and Erwinia chrysanthemi (ErAII) type II ASNases currently used in the clinics are characterized by high in vivo instability, short half-life and the requirement of several administrations to obtain a pharmacologically active concentration. Moreover, they are sensitive to proteases (cathepsin B and asparagine endopepti...
4 Citations Source Cite
Published on Oct 3, 2017in Leukemia & Lymphoma 2.67
Etan Orgel11
Estimated H-index: 11
(SC: University of Southern California),
Nicole M. Mueske6
Estimated H-index: 6
(Children's Hospital Los Angeles)
+ 5 AuthorsSteven D. Mittelman29
Estimated H-index: 29
(SC: University of Southern California)
AbstractAdolescents with acute lymphoblastic leukemia (ALL) develop osteopenia early in therapy, potentially exacerbated by high rates of concurrent Vitamin D deficiency. We conducted a randomized clinical trial testing a Vitamin D-based intervention to improve Vitamin D status and reduce bone density decline. Poor adherence to home supplementation necessitated a change to directly observed therapy (DOT) with intermittent, high-dose Vitamin D3 randomized versus standard of care (SOC). Compared t...
2 Citations Source Cite
Published on Jul 1, 2017in Cancer Research 8.38
Jean-Hugues Parmentier2
Estimated H-index: 2
,
Christina M. Dieli-Conwright14
Estimated H-index: 14
,
Steven D. Mittelman29
Estimated H-index: 29
Source Cite
12345678910