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G W Van Citters
2Publications
2H-index
173Citations
Publications 2
Newest
#1Steven D. MittelmanH-Index: 30
#2G W Van CittersH-Index: 2
Last.Richard N. BergmanH-Index: 96
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Central adiposity is highly correlated with insulin resistance, which is an important risk factor for type 2 diabetes and other chronic diseases. However, in normal individuals, central adiposity can be tolerated for many years without development of impaired glucose tolerance or diabetes. Here we examine longitudinally the mechanisms by which glucose tolerance can be maintained in the face of substantial insulin resistance. Normal dogs were fed a diet enriched with moderate amounts of fat (2 g ...
168 CitationsSource
#1Melvin K. DeaH-Index: 9
#2G W Van CittersH-Index: 2
Last.Richard N. BergmanH-Index: 96
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Troglitazone is an antidiabetic agent that improves the ability of adipocytes to store triglycerides by enhancing their insulin sensitivity. Although potent in insulin-resistant states, the effect of troglitazone on lipid and glucose turnover in normal animals has not been assessed. Euglycemic clamps were performed as an insulin dose response in normal mongrel dogs (n = 6). Somatostatin was infused without hormone replacement (zero insulin) for 90 min. Insulin was then either portally replaced (...
5 CitationsSource
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