Efficacy and Safety of Intranasal Peptide YY3–36 for Weight Reduction in Obese Adults

Context: The gastrointestinal peptide hormone, peptide YY3–36 (PYY3–36), is implicated to be a postprandial satiety factor. Objective: The aim of this study is to assess the safety, tolerability, and efficacy of intranasal PYY3–36 to induce weight loss in obese patients. Design: The study was designed as a randomized, 2-wk, single-blind placebo run-in followed by a 12-wk double-blind, placebo-controlled treatment period. Setting: The study was...