Original paper

Functional Role of Serotonin in Insulin Secretion in a Diet-Induced Insulin-Resistant State

Volume: 156, Issue: 2, Pages: 444 - 452
Published: Nov 26, 2014
Abstract
The physiological role of serotonin, or 5-hydroxytryptamine (5-HT), in pancreatic β-cell function was previously elucidated using a pregnant mouse model. During pregnancy, 5-HT increases β-cell proliferation and glucose-stimulated insulin secretion (GSIS) through the Gαq-coupled 5-HT2b receptor (Htr2b) and the 5-HT3 receptor (Htr3), a ligand-gated cation channel, respectively. However, the role of 5-HT in β-cell function in an insulin-resistant...
Paper Details
Title
Functional Role of Serotonin in Insulin Secretion in a Diet-Induced Insulin-Resistant State
Published Date
Nov 26, 2014
Volume
156
Issue
2
Pages
444 - 452
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