An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A
Abstract
Deletion of UBE3A causes the neurodevelopmental disorder Angelman syndrome (AS), while duplication or triplication of UBE3A is linked to autism. These genetic findings suggest that the ubiquitin ligase activity of UBE3A must be tightly maintained to promote normal brain development. Here, we found that protein kinase A (PKA) phosphorylates UBE3A in a region outside of the catalytic domain at residue T485 and inhibits UBE3A activity toward itself...
Paper Details
Title
An Autism-Linked Mutation Disables Phosphorylation Control of UBE3A
Published Date
Aug 1, 2015
Journal
Volume
162
Issue
4
Pages
795 - 807
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