Executive resting-state network connectivity in migraine without aura.

Published on Oct 1, 2012in Cephalalgia4.438
· DOI :10.1177/0333102412457089
Antonio Russo16
Estimated H-index: 16
(Seconda Università degli Studi di Napoli),
Alessandro Tessitore34
Estimated H-index: 34
(Seconda Università degli Studi di Napoli)
+ 7 AuthorsGioacchino Tedeschi47
Estimated H-index: 47
(Seconda Università degli Studi di Napoli)
Background: Converging neuropsychological evidence suggests that in migraine executive functions (EF) may be affected during interictal periods.Objective: To evaluate the functional connectivity of the fronto-parietal networks (FPN) known to be associated with EF, in migraine without aura (MwoA) patients, in the interictal period, in comparison to healthy controls (HC).Methods: Using resting-state functional MRI (RS-fMRI), we compared functional connectivity within the FPN in 14 patients with MwoA versus 14 sex- and age-matched HC, and assessed the correlation between functional connectivity within FPN, clinical features of MwoA patients, and EF. We used voxel-based morphometry to assess whether between-group differences in functional connectivity were dependent on structural differences.Results: Neuropsychological data revealed no significant executive dysfunction in MwoA patients. RS-fMRI showed that MwoA patients, compared to HC, had significant functional connectivity reduction within the right FPN an...
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