Tolerating Increases in the Serum Creatinine following Aggressive Treatment of Chronic Kidney Disease, Hypertension and Proteinuria: Pre-Renal Success

<b><i>Background:</i></b> Blood pressure (BP) reduction in patients with chronic kidney disease (CKD), particularly with a renin-angiotensin system inhibitor (RASI), commonly leads to an initial decrease in glomerular filtration rate. The current clinical guideline, based on studies with single RASIs, is to tolerate an increase in the serum creatinine only up to 30%. This guideline has aptly guided CKD care for over a...