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Antioxidant and hypoglycemic activities of extract and fractions of Rambutan seeds (Nephelium lappaceum L.)
Abstract
Objective : This research was done  to measure the antioxidants and hypoglycemic activities of Nephelium lappaceum L. seed (NLS) extract and fractions. Methods: The ethanol extract of rambutan seeds were prepared by maseration method and the fractions (n-hexane, ethyl acetate, buthanol and water) by separation of extract based on the polarity. The antioxidant activity was determined by using  superoxide dismutase value (SOD), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity. The hypoglycemic activity was determined by using inhibition of α-glucosidase test. The DPPH scavenging and hypoglycemic activities were analized by median of Inhibitory Concentration (IC-50). Results: The highest SOD activity showed that ethyl acetate and aqueous fraction of NLS were 3.3771 µg/ml and 3.0374 µg/ml. Meanwhile DPPH assay showed that both NLS extract and fractions had low DPPH scavenging activity. Hypoglycemic activity showed that extract of NLS had highest activity as α-glucosidase inhibitor. Conclusion: Nephelium lappaceum L. seed extract and fractions have high SOD antioxidant value but low DPPH scavenging activity and can be used as potential hypoglycemic agent. Key Words: antidiabetic; antioxidants; α-glucosidase; hypoglycemic; scavenging
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2012
Wahyu Widowati6
Estimated H-index: 6
(Maranatha Christian University),
Hana Ratnawati4
Estimated H-index: 4
(Maranatha Christian University)
+ 2 AuthorsFelix Kasim1
Estimated H-index: 1
(Maranatha Christian University)
Cardiovascular disease (CVD) is the first cause of death in the world, CVD has complex and multifactorial process including atherogenic lipoprotein, oxidized low density lipoprotein (LDL), endothelial dysfunction, plaque stability, vascular inflammation, thrombotic and fibrinolytic disorder, exercises and genetic factor. Inhibiting the platelet ag- gregation is one of the CVD prevention. Velvet bean seed (Mucuna pruriens L.) can be found abundantly in Indonesia, but has not been used as herbal m...
3 Citations Source Cite
2010 in Bioresource TechnologyIF: 5.81
Susan Cheplick3
Estimated H-index: 3
(University of Massachusetts Amherst),
Young-In Kwon11
Estimated H-index: 11
(Hannam University)
+ 1 AuthorsKalidas Shetty44
Estimated H-index: 44
(University of Massachusetts Amherst)
Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension. In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitor...
86 Citations Source Cite
Uma D. Palanisamy15
Estimated H-index: 15
(Monash University),
Thamilvaani Manaharan6
Estimated H-index: 6
(University of Malaya)
+ 3 AuthorsTheanmalar Masilamani3
Estimated H-index: 3
Abstract Plant extracts have been suggested as a rich as yet unexplored source of potentially useful anti-diabetic drugs. Recent scientific investigations have confirmed the efficacy of many of these preparations, as effective antioxidants; able to regenerate functional pancreatic beta cells and has a hypoglycemic potential. In this study, the exotic rambutan ( Nephelium lappaceum L.) fruit's rind has been shown to be effective in inhibiting the carbohydrate hydrolyzing enzymes, alpha glucosidas...
33 Citations Source Cite
2004 in Carbohydrate ResearchIF: 2.07
Yong-Mu Kim2
Estimated H-index: 2
(Kangwon National University),
Myeong-Hyeon Wang21
Estimated H-index: 21
(Kangwon National University),
Hae-Ik Rhee12
Estimated H-index: 12
(Kangwon National University)
Abstract Inhibitors of carbohydrate-hydrolysing enzymes play an important role for the treatment of diabetes. To our knowledge, a number of inhibitors such as, 1-deoxynojirimycin, acarbose and voglibose have been identified as a result of screening of secondary metabolites up to now. In this note, we report the inhibitory effect on carbohydrate hydrolysis of ethanol extracts from more than 1400 species of plants with the aim of identifying a potential antihyperglycemic drug. Pinus densiflora bar...
140 Citations Source Cite
1999
Barry Halliwell152
Estimated H-index: 152
,
John M.C. Gutteridge66
Estimated H-index: 66
1. Oxygen is a toxic gas - an introductionto oxygen toxicity and reactive species 2. The chemistry of free radicals and related 'reactive species' 3. Antioxidant defences Endogenous and Diet Derived 4. Cellular responses to oxidative stress: adaptation, damage, repair, senescence and death 5. Measurement of reactive species 6. Reactive species can pose special problems needing special solutions. Some examples. 7. Reactive species can be useful some more examples 8. Reactive species can be poison...
16.1k Citations Download PDF
Jong-Sang Kim10
Estimated H-index: 10
(Kyungpook National University),
Chong-Suk Kwon10
Estimated H-index: 10
(Andong National University),
Kun Ho Son5
Estimated H-index: 5
(Andong National University)
Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress...
303 Citations Source Cite
Y.Y. Lim1
Estimated H-index: 1
(Monash University Malaysia Campus),
J. Murtijaya1
Estimated H-index: 1
(Monash University Malaysia Campus)
The total phenolic content (TPC) and antioxidant activity of fresh and dried Phyllanthus amarus plant materials were evaluated using the Folin-Ciocalteau method, 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity and ferric reducing antioxidant power (FRAP) assays. Different drying treatments led to significant reduction (P<0.05) in antioxidant properties of P. amarus methanolic extracts, with microwave drying causing the highest decrease in TPC and antioxidant activity exhibi...
223 Citations Source Cite
2012 in Natural Product ResearchIF: 1.93
Xiao Nan Yang1
Estimated H-index: 1
(Daegu University),
Sun Chul Kang28
Estimated H-index: 28
(Daegu University)
The antioxidant activities of the water and ethanol extracts of F. koreana flowers were evaluated using DPPH, superoxide anion (• ), and nitric oxide (•NO) radical scavenging activity assays. The SC50 values of the water extract of F. koreana on DPPH, • and •NO were 48.39, 24.36 and 100.21 µg mL−1, respectively. The SC50 values of the ethanol extract of F. koreana on the aforesaid free radicals were 57.50, 49.00 and 146.08 µg mL−1, respectively. Further, the total phenolic contents of both extra...
3 Citations Source Cite
Wanrada Sirisompong1
Estimated H-index: 1
(Kasetsart University),
Wannee Jirapakkul4
Estimated H-index: 4
(Kasetsart University),
Utai Klinkesorn11
Estimated H-index: 11
(Kasetsart University)
Abstract Response surface methodology (RSM) was used to study the effect of moisture content (1.59–18.41 g/100 g), extraction time (2.3–10.7 h) and particle size (0.09–2.11 mm) on the fat yield from rambutan kernels using hexane extraction. The physical and chemical characteristics of rambutan fat were also determined. The optimum conditions obtained from response surface analysis was 4.99 g/100 g moisture, 1.05 mm particle size and 9.2 h extraction time. Under these optimum conditions, the maxi...
29 Citations Source Cite
2005 in Biologia PlantarumIF: 1.42
R. K. Sairam22
Estimated H-index: 22
(Indian Agricultural Research Institute),
Girish Chand Srivastava12
Estimated H-index: 12
(Indian Agricultural Research Institute)
+ 1 AuthorsR. C. Meena10
Estimated H-index: 10
(Indian Agricultural Research Institute)
Effects of long-term sodium chloride salinity (100 and 200 mM NaCl; ECe = 6.85 and 12.3 dS m−1) were studied in tolerant (Kharchia 65, KRL 19) and susceptible (HD 2009, HD 2687) wheat genotypes. NaCl decreased relative water content (RWC), chlorophyll content (Chl), membrane stability index (MSI) and ascorbic acid (AA) content, and increased the contents of hydrogen peroxide, thiobarbituric acid reactive substances (TBARS), and activities of superoxide dismutase (SOD), ascorbate peroxidase (APOX...
277 Citations Source Cite
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