Ethyl acetate

Biochemistry

Food science

Alpha-glucosidase

Superoxide dismutase

Scavenging

Antioxidant

Enzyme

Medicine

Chemistry

Rambutan

DPPH

Ethanol

Traditional medicine

Biomedical engineering

Objective null : This research was done  to measure the antioxidants and hypoglycemic activities of null Nephelium lappaceum null L. seed (NLS) extract and fractions. null null null Methods: null The ethanol extract of rambutan seeds were prepared by maseration method and the fractions (n-hexane, ethyl acetate, buthanol and water) by separation of extract based on the polarity. The antioxidant activity was determined by using  superoxide dismutase value (SOD), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity. The hypoglycemic activity was determined by using inhibition of α-glucosidase test. The DPPH scavenging and hypoglycemic activities were analized by median of Inhibitory Concentration (IC-50). null null Results: null The highest SOD activity showed that ethyl acetate and aqueous fraction of NLS were 3.3771 µg/ml and 3.0374 µg/ml. Meanwhile DPPH assay showed that both NLS extract and fractions had low DPPH scavenging activity. Hypoglycemic activity showed that extract of NLS had highest activity as α-glucosidase inhibitor. null null null Conclusion: null null Nephelium lappaceum null L. seed extract and fractions have high SOD antioxidant value but low DPPH scavenging activity and can be used as potential hypoglycemic agent. null null Key Words: antidiabetic; antioxidants; α-glucosidase; hypoglycemic; scavenging

Antioxidant and hypoglycemic activities of extract and fractions of Rambutan seeds (Nephelium lappaceum L.)