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Antioxidant and hypoglycemic activities of extract and fractions of Rambutan seeds (Nephelium lappaceum L.)

Published on Aug 13, 2015
Sylvia Soeng2
Estimated H-index: 2
(Maranatha Christian University),
Endang Evacuasiany2
Estimated H-index: 2
(Maranatha Christian University)
+ 1 AuthorsNurul Fauziah4
Estimated H-index: 4
Abstract
Objective : This research was done  to measure the antioxidants and hypoglycemic activities of Nephelium lappaceum L. seed (NLS) extract and fractions. Methods: The ethanol extract of rambutan seeds were prepared by maseration method and the fractions (n-hexane, ethyl acetate, buthanol and water) by separation of extract based on the polarity. The antioxidant activity was determined by using  superoxide dismutase value (SOD), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity. The hypoglycemic activity was determined by using inhibition of α-glucosidase test. The DPPH scavenging and hypoglycemic activities were analized by median of Inhibitory Concentration (IC-50). Results: The highest SOD activity showed that ethyl acetate and aqueous fraction of NLS were 3.3771 µg/ml and 3.0374 µg/ml. Meanwhile DPPH assay showed that both NLS extract and fractions had low DPPH scavenging activity. Hypoglycemic activity showed that extract of NLS had highest activity as α-glucosidase inhibitor. Conclusion: Nephelium lappaceum L. seed extract and fractions have high SOD antioxidant value but low DPPH scavenging activity and can be used as potential hypoglycemic agent. Key Words: antidiabetic; antioxidants; α-glucosidase; hypoglycemic; scavenging
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References22
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#1Wahyu Widowati (Maranatha Christian University)H-Index: 7
#2Hana Ratnawati (Maranatha Christian University)H-Index: 4
Last.Felix Kasim (Maranatha Christian University)H-Index: 1
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#1Thamilvaani Manaharan (UM: University of Malaya)H-Index: 7
#2Ling Lai Teng (UM: University of Malaya)H-Index: 2
Last.Uma D. Palanisamy (Monash University)H-Index: 17
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#1C. Hernández-Hernández (Autonomous University of Coahuila)
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Last.Juan A. Ascacio-Valdés (Autonomous University of Coahuila)H-Index: 10
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#2Mohd Shamsul Anuar (UPM: Universiti Putra Malaysia)H-Index: 8
Last.Siti Roha Ab Mutalib (UiTM: Universiti Teknologi MARA)H-Index: 1
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#1So’bah Ahmad (UPM: Universiti Putra Malaysia)H-Index: 1
#2Mohd Shamsul Anuar (UPM: Universiti Putra Malaysia)H-Index: 8
Last.Siti Roha A.M (UiTM: Universiti Teknologi MARA)H-Index: 1
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