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Antioxidant and hypoglycemic activities of extract and fractions of Rambutan seeds (Nephelium lappaceum L.)

Published on Aug 13, 2015
Sylvia Soeng2
Estimated H-index: 2
(Maranatha Christian University),
Endang Evacuasiany2
Estimated H-index: 2
(Maranatha Christian University)
+ 1 AuthorsNurul Fauziah4
Estimated H-index: 4
Abstract
Objective : This research was done  to measure the antioxidants and hypoglycemic activities of Nephelium lappaceum L. seed (NLS) extract and fractions. Methods: The ethanol extract of rambutan seeds were prepared by maseration method and the fractions (n-hexane, ethyl acetate, buthanol and water) by separation of extract based on the polarity. The antioxidant activity was determined by using  superoxide dismutase value (SOD), 1,1-diphenyl-2-picryl-hydrazyl (DPPH) radical scavenging activity. The hypoglycemic activity was determined by using inhibition of α-glucosidase test. The DPPH scavenging and hypoglycemic activities were analized by median of Inhibitory Concentration (IC-50). Results: The highest SOD activity showed that ethyl acetate and aqueous fraction of NLS were 3.3771 µg/ml and 3.0374 µg/ml. Meanwhile DPPH assay showed that both NLS extract and fractions had low DPPH scavenging activity. Hypoglycemic activity showed that extract of NLS had highest activity as α-glucosidase inhibitor. Conclusion: Nephelium lappaceum L. seed extract and fractions have high SOD antioxidant value but low DPPH scavenging activity and can be used as potential hypoglycemic agent. Key Words: antidiabetic; antioxidants; α-glucosidase; hypoglycemic; scavenging
  • References (22)
  • Citations (2)
References22
Newest
Published on Jan 1, 2014in international food research journal
U. Issara1
Estimated H-index: 1
,
Wahidu Zzaman8
Estimated H-index: 8
,
Tajul A. Yang9
Estimated H-index: 9
This review of literature provides an overview on the compositional data of Rambutan (Nephelium lappaceum Linn.) and rambutan seed fat for usage in chocolate product. It is a seasonal fruit native of west Malaysia and Sumatra. It is harvested when the fruit have reached optimum visual and organoleptic quality. Rambutans rapidly deteriorate unless proper handling techniques are employed. The rambutan fruits are deseeded during processing and these seeds (~ 4-9 g/100 g) are a waste by-product of t...
14 Citations
Published on Apr 30, 2013
Lestari Rahayu1
Estimated H-index: 1
,
Latif Zakir1
Estimated H-index: 1
,
Sesilia Andriani Keban1
Estimated H-index: 1
Rambutan (Nephelium lappaceum L.) is a plant which can be used to treat various diseases, including diabetes mellitus. This research was conducted to investigate the effect of rambutan seed infusion on the mice blood glucose levels and body weight. In this research, 30 mice (Mus musculus) were divided into 6 groups, each group consists of 5 mice. The 6 groups consists of a normal control group (distilled water), negative control group (alloxan tetrahydrate 250 mg/kg bw + distilled water), three ...
3 Citations
Published on Jan 1, 2013
Hip Seng Yim8
Estimated H-index: 8
(UCSI University),
Jalan Menara Gading1
Estimated H-index: 1
(UCSI University)
The present study aimed to investigate the effects of ethanol concentration (0- 100%, v/v), extraction time (60-300 min), and extraction temperature (25-60°C) on total phenolic content (TPC) and free radical-scavenging capacity of rambutan (Nephelium lappaceum), mangosteen (Garcinia mangostana), and langsat (Lansium domesticum) peels using single-factor experiments. Folin-Ciocalteu's method was used for the determination of TPC, while the antioxidant capacity was determined by 2,2'-diphenyl-1-pi...
13 Citations
Wahyu Widowati7
Estimated H-index: 7
,
Laura Wijaya4
Estimated H-index: 4
+ 3 AuthorsDian Ratih Laksmitawati4
Estimated H-index: 4
Objective: Cervical cancer is the second most common cancer as well as one of leading cause of cancer-related death for women worldwide. In regards to that issue, focus of this paper will be on popularly used Piperaceae members including Piper betle L, Piper cf fragile Benth, Piper umbellatum L, Piper aduncum L, Piper pellucidum L. This research was conducted to elucidate the antioxidant, anticancer and apoptosis inducing activities of Piperaceae extracts on cervical cancer cells, namely HeLa ce...
23 Citations Source Cite
Published on May 11, 2012
Wahyu Widowati7
Estimated H-index: 7
(Maranatha Christian University),
Hana Ratnawati4
Estimated H-index: 4
(Maranatha Christian University)
+ 2 AuthorsFelix Kasim1
Estimated H-index: 1
(Maranatha Christian University)
Cardiovascular disease (CVD) is the first cause of death in the world, CVD has complex and multifactorial process including atherogenic lipoprotein, oxidized low density lipoprotein (LDL), endothelial dysfunction, plaque stability, vascular inflammation, thrombotic and fibrinolytic disorder, exercises and genetic factor. Inhibiting the platelet ag- gregation is one of the CVD prevention. Velvet bean seed (Mucuna pruriens L.) can be found abundantly in Indonesia, but has not been used as herbal m...
3 Citations Source Cite
Published on Feb 1, 2012in Natural Product Research 1.93
Xiao Nan Yang1
Estimated H-index: 1
(Daegu University),
Sun Chul Kang33
Estimated H-index: 33
(Daegu University)
The antioxidant activities of the water and ethanol extracts of F. koreana flowers were evaluated using DPPH, superoxide anion (• ), and nitric oxide (•NO) radical scavenging activity assays. The SC50 values of the water extract of F. koreana on DPPH, • and •NO were 48.39, 24.36 and 100.21 µg mL−1, respectively. The SC50 values of the ethanol extract of F. koreana on the aforesaid free radicals were 57.50, 49.00 and 146.08 µg mL−1, respectively. Further, the total phenolic contents of both extra...
4 Citations Source Cite
Published on Nov 1, 2011in Lwt - Food Science and Technology 3.13
Wanrada Sirisompong1
Estimated H-index: 1
(Kasetsart University),
Wannee Jirapakkul4
Estimated H-index: 4
(Kasetsart University),
Utai Klinkesorn11
Estimated H-index: 11
(Kasetsart University)
Abstract Response surface methodology (RSM) was used to study the effect of moisture content (1.59–18.41 g/100 g), extraction time (2.3–10.7 h) and particle size (0.09–2.11 mm) on the fat yield from rambutan kernels using hexane extraction. The physical and chemical characteristics of rambutan fat were also determined. The optimum conditions obtained from response surface analysis was 4.99 g/100 g moisture, 1.05 mm particle size and 9.2 h extraction time. Under these optimum conditions, the maxi...
31 Citations Source Cite
Published on Aug 1, 2011in Food Research International 3.52
Uma D. Palanisamy17
Estimated H-index: 17
(Monash University),
Thamilvaani Manaharan7
Estimated H-index: 7
(University of Malaya)
+ 3 AuthorsTheanmalar Masilamani4
Estimated H-index: 4
Abstract Plant extracts have been suggested as a rich as yet unexplored source of potentially useful anti-diabetic drugs. Recent scientific investigations have confirmed the efficacy of many of these preparations, as effective antioxidants; able to regenerate functional pancreatic beta cells and has a hypoglycemic potential. In this study, the exotic rambutan ( Nephelium lappaceum L.) fruit's rind has been shown to be effective in inhibiting the carbohydrate hydrolyzing enzymes, alpha glucosidas...
33 Citations Source Cite
Published on May 1, 2010in European Journal of Preventive Cardiology 4.54
Dieren Susan van1
Estimated H-index: 1
,
Joline W.J. Beulens48
Estimated H-index: 48
+ 2 AuthorsBruce Nealb1
Estimated H-index: 1
(University of Sydney)
The number of patients with type 2 diabetes is increasing rapidly in both developed and developing countries around the world. The emerging pandemic is driven by the combined effects of population ageing, rising levels of obesity and inactivity, and greater longevity among patients with diabetes that is attributable to improved management. The vascular complications of type 2 diabetes account for the majority of the social and economic burden among patients and society more broadly. This review ...
404 Citations Source Cite
Published on Jan 1, 2010in Bioresource Technology 5.81
CheplickSusan3
Estimated H-index: 3
(University of Massachusetts Amherst),
Young-In Kwon30
Estimated H-index: 30
(Hannam University)
+ 1 AuthorsKalidas Shetty56
Estimated H-index: 56
(University of Massachusetts Amherst)
Fruit extracts of different strawberry cultivars were evaluated for their potential to contribute to the dietary management of hyperglycemia-linked to type 2 diabetes and related hypertension. In vitro inhibition of α-amylase, α-glucosidase, and angiotensin-1-converting enzyme (ACE) activity was evaluated using fruit extracts and correlated to phenolic content and antioxidant activity. There were significant differences between cultivars in both phenolic-linked antioxidant activity and inhibitor...
88 Citations Source Cite
Cited By2
Newest
Published on Mar 1, 2019in Trends in Food Science and Technology 6.61
C. Hernández-Hernández (Autonomous University of Coahuila), Cristóbal Noe34
Estimated H-index: 34
(Autonomous University of Coahuila)
+ 4 AuthorsJuan A. Ascacio-Valdés10
Estimated H-index: 10
(Autonomous University of Coahuila)
Abstract Background The rambutan ( Nephelium lappaceum L) is an exotic fruit native to the Southeast Asia and currently cultivated in different tropical areas, among them in southern Mexico. It is characterized by its nutritionals and functionals properties and has been relevant for its commercialization and acceptance in different countries and Mexico represents one of the main producers and exporter of rambutan in the world. Scope and approach In this review, we summarize information about of ...
Source Cite
Published on May 1, 2017
So’bah Ahmad1
Estimated H-index: 1
(Universiti Putra Malaysia),
Mohd Shamsul Anuar8
Estimated H-index: 8
(Universiti Putra Malaysia)
+ 2 AuthorsSiti Roha A.M1
Estimated H-index: 1
(Universiti Teknologi MARA)
The effects of two drying methods, oven and microwave drying on the effective moisture diffusivity and activation energy of rambutan seed were studied. Effective moisture diffusivity and activation energy are the main indicators used for moisture movement within the material. Hence, it is beneficial to determine an appropriate drying method to attain a final moisture content of rambutan seed that potentially could be used as secondary sources in the industry. An appropriate final moisture conten...
2 Citations Source Cite