Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
Abstract
Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select few tissues. Here we show that human mammary epithelial cells (HMECs) from BRCA1-mutation carriers (BRCA1(mut/+)) exhibit increased genomic instability and rapid telomere erosion in the absence of tumour-suppressor loss....
Paper Details
Title
Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence
Published Date
Jun 24, 2015
Journal
Volume
6
Issue
1
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