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HDL and arteriosclerosis: beyond reverse cholesterol transport

Published on Mar 1, 2002in Atherosclerosis4.25
· DOI :10.1016/S0021-9150(01)00651-7
Jerzy-Roch Nofer28
Estimated H-index: 28
,
Beate E. Kehrel39
Estimated H-index: 39
+ 3 AuthorsA. von Eckardstein70
Estimated H-index: 70
Cite
Abstract
Abstract The inverse correlation between serum levels of high density lipoprotein (HDL) cholesterol and the risk of coronary heart disease, the protection of susceptible animals from atherosclerosis by transgenic manipulation of HDL metabolism, and several potentially anti-atherogenic in vitro-properties have made HDL metabolism an interesting target for pharmacological intervention in atheroslcerosis. We have previously reviewed the concept of reverse cholesterol transport, which describes both the metabolism and the classic anti-atherogenic function of HDL (Arterioscler. Thromb. Vasc. Biol. 20 2001 13). We here summarize the current understanding of additional biological, potentially anti-atherogenic properties of HDL. HDL inhibits the chemotaxis of monocytes, the adhesion of leukocytes to the endothelium, endothelial dysfunction and apoptosis, LDL oxidation, complement activation, platelet activation and factor X activation but also stimulates the proliferation of endothelial cells and smooth muscle cells, the synthesis of prostacyclin and natriuretic peptide C in endothelial cells, and the activation of proteins C and S. These anti-inflammatory, anti-oxidative, anti-aggregatory, anti-coagulant, and pro-fibrinolytic activities are exerted by different components of HDL, namley apolipoproteins, enzymes, and even specific phospholipids. This complexity further emphasizes that changes in the functionality of HDL rather than changes of plasma HDL-cholesterol levels determine the anti-atherogenicity of therapeutic alterations of HDL metabolism.
  • References (204)
  • Citations (461)
Cite
References204
Newest
Published on Apr 3, 2001in Circulation23.05
Paul M. Ridker192
Estimated H-index: 192
(Brigham and Women's Hospital)
Abstract—Inflammation plays a major role in atherothrombosis, and measurement of inflammatory markers such ashigh-sensitivity C-reactive protein (HSCRP) may provide a novel method for detecting individuals at high risk of plaquerupture. Several large-scale prospective studies demonstrate that HSCRP is a strong independent predictor of futuremyocardial infarction and stroke among apparently healthy men and women and that the addition of HSCRP to standardlipid screening may improve global risk pre...
Published on Jan 1, 2001in Atherosclerosis4.25
Javier Pedreño7
Estimated H-index: 7
,
Conxita de Castellarnau2
Estimated H-index: 2
,
Lluís Masana36
Estimated H-index: 36
Abstract Early studies considered that fibrinogen receptor (glycoprotein [GP] IIb–IIIa or platelet integrin α IIb β 3 ) is the binding site for low-density lipoprotein (LDL) and high-density lipoprotein type 3 (HDL 3 ). Recent data, however, do not support the hypothesis that the binding of LDL to human intact resting platelets is related to integrin α IIb β 3 . In this study we present evidence that platelet integrin α IIb β 3 is also not involved in the interaction of HDL 3 and human intact re...
Published on Jan 1, 2001in Thrombosis and Haemostasis4.73
Jerzy-Roch Nofer28
Estimated H-index: 28
,
Ralf Junker42
Estimated H-index: 42
+ 6 AuthorsMichael Walter19
Estimated H-index: 19
In this study we found that HDL acts as a potent and specific mitogen in vascular smooth muscle cells (VSMC) by stimulating entry into S-phase and DNA synthesis in a time- and concentration-dependent manner, induction of cyclins D1, E, and A, as well as activation of cyclin D-dependent kinases as inferred from phosphorylation of the retinoblastoma protein (pRb). Moreover, HDL induced activation of the mitogen-activated protein kinase pathway including Raf-, MEK-1, and ERK1/2, as well as the expr...
Published on Jan 1, 2001in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
A. von Eckardstein70
Estimated H-index: 70
,
Jerzy-Roch Nofer28
Estimated H-index: 28
,
Gerd Assmann Frcp86
Estimated H-index: 86
Abstract —High density lipoprotein (HDL) cholesterol is an important risk factor for coronary heart disease, and HDL exerts various potentially antiatherogenic properties, including the mediation of reverse transport of cholesterol from cells of the arterial wall to the liver and steroidogenic organs. Enhancement of cholesterol efflux and of reverse cholesterol transport (RCT) is considered an important target for antiatherosclerotic drug therapy. Levels and composition of HDL subclasses in plas...
Published on Dec 1, 2000in Biochemistry2.95
Nofer2
Estimated H-index: 2
,
Manfred Fobker34
Estimated H-index: 34
+ 9 Authorsvon Eckardstein A2
Estimated H-index: 2
Our earlier studies demonstrated that high-density lipoproteins (HDLs) stimulate multiple signaling pathways, including activation of phosphatidylcholine-specific phospholipases C and D (PC-PLs) and phosphatidylinositol-specific phospholipase C (PI-PLC). However, only activation of PC-PLs was linked to the HDL-induced cholesterol efflux. In the study presented here, the role of HDL-induced PI-PLC activation was studied. In human skin fibroblasts, HDL potently induced PI-PLC as inferred from enha...
Published on Oct 1, 2000in Arteriosclerosis, Thrombosis, and Vascular Biology6.62
B. De Geest26
Estimated H-index: 26
,
Dominique Stengel25
Estimated H-index: 25
+ 5 AuthorsEwa Ninio20
Estimated H-index: 20
Abstract —Various mechanisms may contribute to the antiatherogenic potential of apolipoprotein A-I (apo A-I) and high density lipoproteins (HDLs). Therefore, the effect of adenovirus-mediated human apo A-I gene transfer or human apo A-I transgenesis on platelet-activating factor acetylhydrolase (PAF-AH) and arylesterase/paraoxonase (PON1) was studied in C57BL/6 and C57BL/6 apo E−/− mice. Human apo A-I transgenesis in C57BL/6 mice resulted in a 4.2-fold ( P <0.0001) increase of PAF-AH and a 1.7-f...
Published on Oct 1, 2000in The FASEB Journal5.39
Gregor Theilmeier29
Estimated H-index: 29
,
B. De Geest26
Estimated H-index: 26
+ 9 AuthorsDesire Collen130
Estimated H-index: 130
Macrophage infiltration into the subendothelial space at lesion prone sites is the primary event in atherogenesis. Inhibition of macrophage homing might therefore prevent atherosclerosis. Since HDL levels are inversely correlated with cardiovascular risk, their effect on macrophage homing was assessed in apoE-deficient (apoE−/−) mice. Overexpression of human apolipoprotein AI in apoE−/− mice increased HDL levels 3-fold and reduced macrophage accumulation in an established assay of leukocyte homi...
Published on Sep 1, 2000in Blood Coagulation & Fibrinolysis1.12
Margitta Neufeld4
Estimated H-index: 4
,
Jerzy-Roch Nofer28
Estimated H-index: 28
+ 3 AuthorsRalf Junker42
Estimated H-index: 42
High levels of fibrinogen and low levels of high-density lipoprotein (HDL) cholesterol were reported to be risk factors for coronary heart disease. CD11b/CD18, a fibrinogen-binding protein, is expressed on the surface of monocytes, which play a crucial role in the formation of atherosclerotic lesions. In the present study, we investigate the effects of antibodies against CD11b and CD18, as well as HDL 3 and low-density lipoprotein (LDL) cholesterol on fibrinogen binding on monocytes. We find tha...
Published on Sep 1, 2000in Current Opinion in Cardiology1.98
von Eckardstein A2
Estimated H-index: 2
,
Nofer2
Estimated H-index: 2
,
Gerd Assmann13
Estimated H-index: 13
Cited By461
Newest
Published on Dec 1, 2019in Nutrition & Metabolism3.60
Kuen-Ming Wu (Jen-Ai Hospital), Yuan-Man Hsu18
Estimated H-index: 18
(PRC: China Medical University (PRC))
+ 10 AuthorsPo-Hua Su (Jen-Ai Hospital)
Background High levels circulating saturated fatty acids are associated with diabetes, obesity and hyperlipidemia. In heart, the accumulation of saturated fatty acids has been determined to play a role in the development of heart failure and diabetic cardiomyopathy. High-density lipoprotein (HDL) has been reported to possess key atheroprotective biological properties, including cellular cholesterol efflux capacity, anti-oxidative and anti-inflammatory activities. However, the underlying mechanis...
Published on Dec 1, 2019in Annals of Intensive Care3.93
Sébastien Tanaka (University of La Réunion), Devy Diallo4
Estimated H-index: 4
(French Institute of Health and Medical Research)
+ 10 AuthorsErick Denamur36
Estimated H-index: 36
(Paris Diderot University)
Background Sepsis is associated with systemic inflammation that may impact lipoprotein function. In particular, high-density lipoproteins (HDLs) that display pleiotropic protective roles may be dysfunctional in septic conditions. The aim of this study was to evaluate the HDL profile and the inflammatory context in septic shock patients admitted to our intensive care unit (ICU).
Published on May 29, 2019in Molecules3.06
Esther Coto , Nélida Fernández9
Estimated H-index: 9
+ 3 AuthorsMatilde Sierra-Vega11
Estimated H-index: 11
Many publications have described the potential cardioprotective action of different medicinal plants, relating this effect with blood lipid levels. However, these publications do not justify the right amount of plant administered, which can vary greatly. Sideritis hyssopifolia is a little woody plant endemic to western and southwestern Europe. We have quantified its antioxidant activity, which can be used as an indicator of its cardioprotective action. This study evaluates the antioxidant capaci...
Published on May 21, 2019in Current Medicinal Chemistry3.89
Valentina Arnao14
Estimated H-index: 14
(University of Palermo),
Antonino Tuttolomondo32
Estimated H-index: 32
(University of Palermo)
+ 1 AuthorsAntonio Pinto40
Estimated H-index: 40
(University of Palermo)
Published on May 2, 2019in International Journal of Rheumatic Diseases1.94
Ju-Yang Jung10
Estimated H-index: 10
(Ajou University),
Hyoun-Ah Kim18
Estimated H-index: 18
(Ajou University)
+ 1 AuthorsChang-Hee Suh23
Estimated H-index: 23
(Ajou University)
Published on Apr 1, 2019in Scandinavian Journal of Medicine & Science in Sports3.63
Alba Camacho-Cardenosa2
Estimated H-index: 2
(University of Extremadura),
Marta Camacho-Cardenosa2
Estimated H-index: 2
(University of Extremadura)
+ 2 AuthorsJavier Brazo-Sayavera4
Estimated H-index: 4
Published on Mar 1, 2019in Science of The Total Environment5.59
Xiangmei (May) Wu1
Estimated H-index: 1
(CDFW: California Department of Fish and Wildlife),
Rachel Broadwin15
Estimated H-index: 15
(CDFW: California Department of Fish and Wildlife)
+ 7 AuthorsSungKyun Park (UM: University of Michigan)
Abstract Fine particles (PM 2.5 ) are known to increase risks of cardiovascular diseases, but it is unclear how they affect plasma lipid levels. In this study, we examined the associations between PM 2.5 exposure and lipid/lipoprotein levels from 2289 midlife women enrolled in the longitudinal Study of Women's Health Across the Nation. The average exposure to PM 2.5 and gaseous co-pollutants during the prior one year, six months, 30 days, and one day were estimated for each woman based on U.S. E...
Published on Jan 1, 2019
Kyung-Hyun Cho28
Estimated H-index: 28
(Yeungnam University)
Repetitive exercise and physical training is well correlated with a reduction of the risk of atherosclerosis, coupled with an increase in serum high density lipoprotein-cholesterol (HDL-C) (Kraus et al. 2002). Plasma apoA-I and HDL-cholesterol levels are also evidently higher in trained athletes than in sedentary age-matched reference people (Sasaki et al. 1988). Regular exercise is known to be advantageous with regard to lipid and lipoprotein metabolism in healthy normolipidemic men and women, ...
Published on Jan 1, 2019
Genevieve Mezoh (University of the Witwatersrand), Nigel J. Crowther28
Estimated H-index: 28
(University of the Witwatersrand)
Cardiovascular disease (CVD), as a possible consequence of endothelial dysfunction, is prevalent among HIV-infected patients despite successful administration of antiretroviral drugs. This warrants the routine clinical assessment of endothelial function in HIV-positive patients to circumvent potential CVD events. Several different non-invasive strategies have been employed to assess endothelial function in clinical research studies yielding inconsistencies among these reports. This review summar...
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