Jerzy-Roch Nofer
University of Münster
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Publications 110
#1Bettina HesseH-Index: 1
#2Alexandros RovasH-Index: 2
Last. Alexander LukaszH-Index: 14
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Dysfunctional high-density lipoprotein (d-HDL) in chronic kidney disease is known to have a change in composition towards an endothelial-damaging phenotype, amongst others, via the accumulation of symmetric dimethylarginine. The endothelial glycocalyx, a carbohydrate-rich layer lining the endothelial luminal surface, is a first line defense against vascular diseases including atherosclerosis. Here we conducted a translational, cross-sectional study to determine the role of symmetric dimethylargi...
1 CitationsSource
#1Francesco PotìH-Index: 11
#2Renata FeuerbornH-Index: 7
Last. Jerzy-Roch NoferH-Index: 29
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#2Francesco PotìH-Index: 11
Last. A. von EckardsteinH-Index: 73
view all 7 authors...
#1Renata Feuerborn (WWU: University of Münster)H-Index: 7
#2Manuela Besser (WWU: University of Münster)H-Index: 1
Last. Jerzy-Roch Nofer (WWU: University of Münster)H-Index: 29
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Background Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid and a constituent of high-density lipoprotein (HDL) exerting several atheroprotective effects in vitro. However, the few studies addressing anti-atherogenic effects of S1P in vivo have led to disparate results. We here examined atherosclerosis development in low-density lipoprotein receptor (LDL-R)-deficient (LDL-R−/−) mice with elevated endogenous S1P levels. Methods and Results Sub-lethally irradiated LDL-R−/− mice were t...
4 CitationsSource
#1Frank KannenbergH-Index: 17
#2Manfred FobkerH-Index: 34
Last. Andreas N. SchüringH-Index: 16
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Abstract Background Simultaneous measurement of testosterone (T) and 5α-dihydrotestosterone (DHT) is important for diagnosing androgen deficiency states and hyperandrogenism in males and females, respectively. However, immunoassays used for T and DHT determination suffer from inadequate specificity and sensitivity, while tandem mass spectrometry is expensive and demanding in use. Methods and results We developed a selective gas chromatography–mass spectrometry (GC–MS) method for parallel T and D...
Abstract Niemann-Pick type C (NPC) is a neurological disease caused by an intracellular cholesterol accumulation. Cholesterol oxidation product cholestane-3β,5α,6β-triol (C-triol) serves as diagnostic biomarker for NPC, but its measurement in the routine laboratory remains difficult. We developed an isotope dilution gas chromatography–mass spectrometry (GC–MS) method permitting screening for NPC in plasma. 1440 plasma samples obtained from clinically suspicious patients were subjected to alkalin...
11 CitationsSource
#1Ilaria Zanotti (University of Parma)H-Index: 18
#2D. Greco (University of Parma)H-Index: 4
Last. Francesco Potì (University of Parma)H-Index: 11
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#1S. JungeH-Index: 11
#2Dennis GörlichH-Index: 16
Last. Barbara C. KahlH-Index: 28
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textabstractBackground Staphylococcus aureus is an important pathogen in cystic fibrosis (CF). However, it is not clear which factors are associated with worse lung function in patients with persistent S. aureus airway cultures. Our main hypothesis was that patients with high S. aureus density in their respiratory specimens would more likely experience worsening of their lung disease than patients with low bacterial loads. Methods Therefore, we conducted an observational prospective longitudinal...
19 CitationsSource
#1Tobias M. NowackiH-Index: 9
#2Alan T. Remaley (NIH: National Institutes of Health)H-Index: 66
Last. Jerzy-Roch NoferH-Index: 29
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Background and PurposeNew therapies for inflammatory bowel disease (IBD) are highly desirable. As apolipoprotein (apo)A-I mimetic peptides are beneficial in several animal models of inflammation, we hypothesized that they might be effective at inhibiting murine colitis. Experimental ApproachDaily injections of 5A peptide, a synthetic bihelical apoA-I mimetic dissolved in PBS, or PBS alone were administered to C57BL/6 mice fed 3% (w v(-1)) dextran sodium sulfate (DSS) in drinking water or healthy...
5 CitationsSource
Background Determination of plasma testosterone is critical for the proper diagnosis of polycystic ovary syndrome (PCOS), but the interpretation of biochemical tests is hampered by inadequate specificity and precision of available immunoassays. We here compared the diagnostic performance of three testosterone immunoassays (Advia Centaur, Immulite 2000 XPi, Cobas e411) in PCOS patients using receiver operator characteristics curve analysis. Methods and Results Plasma levels of testosterone, andro...
2 CitationsSource