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Jerzy-Roch Nofer
University of Münster
104Publications
28H-index
3,573Citations
Publications 104
Newest
Published on 2019in Atherosclerosis4.25
Francesco Potì11
Estimated H-index: 11
,
Renata Feuerborn7
Estimated H-index: 7
+ 5 AuthorsJerzy-Roch Nofer28
Estimated H-index: 28
Published on Aug 1, 2018in Thrombosis and Haemostasis4.73
Renata Feuerborn7
Estimated H-index: 7
(WWU: University of Münster),
Manuela Besser1
Estimated H-index: 1
(WWU: University of Münster)
+ 7 AuthorsJerzy-Roch Nofer28
Estimated H-index: 28
(WWU: University of Münster)
Background Sphingosine-1-phosphate (S1P) is a bioactive lysosphingolipid and a constituent of high-density lipoprotein (HDL) exerting several atheroprotective effects in vitro. However, the few studies addressing anti-atherogenic effects of S1P in vivo have led to disparate results. We here examined atherosclerosis development in low-density lipoprotein receptor (LDL-R)-deficient (LDL-R −/− ) mice with elevated endogenous S1P levels. Methods and Results Sub-lethally irradiated LDL-R −/− mice wer...
Published on Jan 1, 2018in Clinica Chimica Acta2.73
Frank Kannenberg17
Estimated H-index: 17
,
Manfred Fobker34
Estimated H-index: 34
+ 5 AuthorsAndreas N. Schüring17
Estimated H-index: 17
• We developed precise and inexpensive GC–MS method for testosterone and DHT measurement.
Frank Kannenberg17
Estimated H-index: 17
,
Jerzy-Roch Nofer28
Estimated H-index: 28
+ 3 AuthorsManfred Fobker34
Estimated H-index: 34
Abstract Niemann-Pick type C (NPC) is a neurological disease caused by an intracellular cholesterol accumulation. Cholesterol oxidation product cholestane-3β,5α,6β-triol (C-triol) serves as diagnostic biomarker for NPC, but its measurement in the routine laboratory remains difficult. We developed an isotope dilution gas chromatography–mass spectrometry (GC–MS) method permitting screening for NPC in plasma. 1440 plasma samples obtained from clinically suspicious patients were subjected to alkalin...
Published on Jan 1, 2017in Nutrition Metabolism and Cardiovascular Diseases3.34
Ilaria Zanotti17
Estimated H-index: 17
(University of Parma),
D. Greco3
Estimated H-index: 3
(University of Parma)
+ 7 AuthorsFrancesco Potì11
Estimated H-index: 11
(University of Parma)
Published on Nov 18, 2016in PLOS ONE2.78
S. Junge11
Estimated H-index: 11
,
Dennis Görlich15
Estimated H-index: 15
+ 26 AuthorsCordula Koerner-Rettberg11
Estimated H-index: 11
(RUB: Ruhr University Bochum)
textabstractBackground Staphylococcus aureus is an important pathogen in cystic fibrosis (CF). However, it is not clear which factors are associated with worse lung function in patients with persistent S. aureus airway cultures. Our main hypothesis was that patients with high S. aureus density in their respiratory specimens would more likely experience worsening of their lung disease than patients with low bacterial loads. Methods Therefore, we conducted an observational prospective longitudinal...
Published on Sep 1, 2016in Journal of Clinical Laboratory Analysis1.73
Andreas N. Schüring17
Estimated H-index: 17
,
Stefan Nolte1
Estimated H-index: 1
+ 2 AuthorsJerzy-Roch Nofer28
Estimated H-index: 28
Background Determination of plasma testosterone is critical for the proper diagnosis of polycystic ovary syndrome (PCOS), but the interpretation of biochemical tests is hampered by inadequate specificity and precision of available immunoassays. We here compared the diagnostic performance of three testosterone immunoassays (Advia Centaur, Immulite 2000 XPi, Cobas e411) in PCOS patients using receiver operator characteristics curve analysis. Methods and Results Plasma levels of testosterone, andro...
Published on Sep 1, 2016in British Journal of Pharmacology6.58
Tobias M. Nowacki7
Estimated H-index: 7
,
Alan T. Remaley65
Estimated H-index: 65
(NIH: National Institutes of Health)
+ 9 AuthorsAndreas Lügering25
Estimated H-index: 25
Background and PurposeNew therapies for inflammatory bowel disease (IBD) are highly desirable. As apolipoprotein (apo)A-I mimetic peptides are beneficial in several animal models of inflammation, we hypothesized that they might be effective at inhibiting murine colitis. Experimental ApproachDaily injections of 5A peptide, a synthetic bihelical apoA-I mimetic dissolved in PBS, or PBS alone were administered to C57BL/6 mice fed 3% (w v(-1)) dextran sodium sulfate (DSS) in drinking water or healthy...
Published on Aug 27, 2015in PLOS ONE2.78
Jan Larmann11
Estimated H-index: 11
(MHH: Hannover Medical School),
Kerstin Jurk22
Estimated H-index: 22
+ 6 AuthorsGregor Theilmeier10
Estimated H-index: 10
(MHH: Hannover Medical School)
Objective Atherosclerosis, a chronic inflammatory disease, arises from metabolic disorders and is driven by inappropriate recruitment and proliferation of monocytes / macrophages and vascular smooth-muscle-cells. The receptor for the urokinase-type plasminogen activator (uPAR, Plaur) regulates the proteolytic activation of plasminogen. It is also a coactivator of integrins and facilitates leukocyte-endothelial interactions and vascular smooth-muscle-cell migration. The role of uPAR in atherogene...
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