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Evaluation of the aphrodisiac activity of Tribulus terrestris Linn. in sexually sluggish male albino rats

Published on Jan 1, 2012in Journal of Pharmacology and Pharmacotherapeutics
· DOI :10.4103/0976-500X.92512
Surender Singh25
Estimated H-index: 25
(AIIMS: All India Institute of Medical Sciences),
Vinod Nair9
Estimated H-index: 9
(AIIMS: All India Institute of Medical Sciences),
Yogendra Kumar Gupta34
Estimated H-index: 34
(AIIMS: All India Institute of Medical Sciences)
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Abstract
Objectives: To study the effect of acute and repeated dose administration of lyophilized aqueous extract of the dried fruits of Tribulus terrestris (LAET) on sexual function in sexually sluggish male albino rats. Materials and Methods: Aphrodisiac activity of the test drug was evaluated in terms of exhibited sexual behavior. In order to assess the effect of chronic T. terrestris exposure on the hypothalamus--pituitary--gonadal axis, testosterone level estimation and sperm count were carried out. Twenty-eight-day oral toxicity studies were carried out to evaluate the long-term effects of the LAET administration on different body systems. Results: A dose-dependent improvement in sexual behavior was observed with the LAET treatment as characterized by an increase in mount frequency, intromission frequency, and penile erection index, as well as a decrease in mount latency, intromission latency, and ejaculatory latency. The enhancement of sexual behavior was more prominent on chronic administration of LAET. Chronic administration of LAET produced a significant increase in serum testosterone levels with no significant effect on the sperm count. No overt body system dysfunctions were observed in 28-day oral toxicity study. Conclusions: Findings of the present study validate the traditional use of T. terrestris as a sexual enhancer in the management of sexual dysfunction in males.
  • References (20)
  • Citations (34)
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References20
Newest
Published on May 1, 2010in European Urology 17.30
Konstantinos Hatzimouratidis24
Estimated H-index: 24
(A.U.Th.: Aristotle University of Thessaloniki),
Edouard Amar10
Estimated H-index: 10
+ 5 AuthorsEric Wespes30
Estimated H-index: 30
Context: Erectile dysfunction (ED) and premature ejaculation (PE) are the two most prevalent male sexual dysfunctions. Objective: To present the updated version of 2009 European Association of Urology (EAU) guidelines on ED and PE. Evidence acquisition: A systematic review of the recent literature on the epidemiology, diagnosis, and treatment of ED and PE was performed. Levels of evidence and grades of recommendation were assigned. Evidence synthesis: ED is highly prevalent, and 5–20% of men hav...
Published on Jan 1, 2008in Phytomedicine 4.18
Kalamegam Gauthaman23
Estimated H-index: 23
(NUS: National University of Singapore),
Adaikan P. Ganesan2
Estimated H-index: 2
(NUS: National University of Singapore)
Abstract Hormonal effects of Tribulus terrestris (TT) were evaluated in primates, rabbit and rat to identify its usefulness in the management of erectile dysfunction (ED). TT extract was administered intravenously, as a bolus dose of 7.5, 15 and 30 mg/kg, in primates for acute study. Rabbits and normal rats were treated with 2.5, 5 and 10 mg/kg of TT extract orally for 8 weeks, for chronic study. In addition, castrated rats were treated either with testosterone cypionate (10 mg/kg, subcutaneousl...
Published on Jun 1, 2007in Hormones and Behavior 3.95
Elaine M. Hull52
Estimated H-index: 52
(FSU: Florida State University),
Juan M. Dominguez20
Estimated H-index: 20
(FSU: Florida State University)
The hormonal factors and neural circuitry that control copulation are similar across rodent species, although there are differences in specific behavior patterns. Both estradiol (E) and dihydrotestosterone (DHT) contribute to the activation of mating, although E is more important for copulation and DHT for genital reflexes. Hormonal activation of the medial preoptic area (MPOA) is most effective, although implants in the medial amygdala (MeA) can also stimulate mounting in castrates. Chemosensor...
Published on Jan 1, 2007
Tienda online donde Comprar Indian Medicinal Plants · An Illustrated Dictionary al precio 199,45 € de Khare, C.P., tienda de Libros de Medicina, Libros de Epidemiologia, Salud Publica y Estadistica - Medicina alternativa
Published on Jan 1, 2007
C. P. Khare1
Estimated H-index: 1
A-Z presentation of Indian medicinal plants including taxonomy, traditional and international synonyms, plant parts, applications and pharmacokinetic action.
Published on Nov 1, 2005in International Journal of Impotence Research 1.25
Paola Zanoli20
Estimated H-index: 20
,
Marianna Rivasi7
Estimated H-index: 7
+ 3 AuthorsMario Baraldi27
Estimated H-index: 27
The influence of the single components of Ferula hermonis extract on sexual behavior was studied in male rats. Sexually potent and sluggish/impotent animals were orally treated acutely (2.5 mg/kg) and subchronically (0.25 mg/kg/day for 10 days) with ferutinin, teferdin and teferin. Ferutinin alone acutely administered in potent rats was able to reduce mount and intromission latencies, while in sluggish/impotent animals, it induced the same effects and additionally shortened the ejaculation laten...
Published on Apr 1, 2004in Fertility and Sterility 5.41
Stefan S. du Plessis25
Estimated H-index: 25
(Stellenbosch University),
Paul S de Jongh1
Estimated H-index: 1
(Stellenbosch University),
Daniel R. Franken34
Estimated H-index: 34
(Stellenbosch University)
Abstract Objective To determine the effect of acute in vivo sildenafil citrate (VIAGRA) and in vitro 8-Bromo-cGMP treatments on semen parameters and sperm function. Design Prospective double-blind, placebo-controlled, crossover, two-period clinical investigation. Setting Healthy volunteers in an academic research environment. Patient(s) Twenty male volunteers with normal erectile function and normal electrocardiogram were recruited. Intervention(s) In vivo: 50 mg of sildenafil citrate (VIAGRA) o...
Published on Aug 1, 2002in Life Sciences 3.45
Kalamegam Gauthaman23
Estimated H-index: 23
(NUS: National University of Singapore),
P.G Adaikan3
Estimated H-index: 3
(NUS: National University of Singapore),
R.N.V. Prasad10
Estimated H-index: 10
(NUS: National University of Singapore)
Abstract Tribulus terrestris (TT) has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions in man. Sexual behaviour and intracavernous pressure (ICP) were studied in both normal and castrated rats to further understand the role of TT containing protodioscin (PTN) as an aphrodisiac. Adult Sprague-Dawley rats were divided into five groups of 8 each that included distilled water treated (n...
Published on Jan 1, 2001in The Aging Male 2.50
P.G Adaikan3
Estimated H-index: 3
,
Kalamegam Gauthaman23
Estimated H-index: 23
,
R.N.V. Prasad10
Estimated H-index: 10
Phytochemicals have played a vital role in the past and will continue to do so in the future. Although synthetic drugs can produce dramatic results in most cases, the side-effects associated with them are a major concern. The source of many compounds used in modern medicine today can be traced down to plant origin. Whether or not scientific justification is available for the use of most plant products, the continued use of these compounds is due to their safety profile, ease of availability and ...
Published on Jan 1, 2001in Planta Medica 2.75
Lifeng Cai1
Estimated H-index: 1
,
Yijie Wu2
Estimated H-index: 2
+ 4 AuthorsDong-Ming Xu6
Estimated H-index: 6
Three new steroidal saponins were isolated from the fruits of Tribulus terrestris, and their structures were elucidated as (25R,S)-5a-spirostane-12-one-3β-ol-3-O-β-xylopyranosyl(1→2)-[β-xylopyranosyl(1→3)]-β-glucopyranosyl(1→4)-[α-rhamnopyranosyl(1→2)]-β-galactopyranoside; 26-O-β-glucopyranosyl-(25S)-5α-furostane-12-one-3β,22α,26-triol-3-O-β-glucopyranosyl(1→2)-β-galactopyranoside; 26-O-β-glucopyranosyl-(25S)-5α-furostane-12-one-3β,22α,26-triol-3-O-β-glucopyranosyl(1→4)-[α-rhamnopyranosyl(1→2)]-...
Cited By34
Newest
Ivanka Semerdjieva2
Estimated H-index: 2
,
Valtcho D. Zheljazkov25
Estimated H-index: 25
(OSU: Oregon State University)
Tribulus terrestris L. (TT) (puncturevine) is a common weed that grows in many countries worldwide and in some places is considered as a noxious weed. The plant has been used in traditional Chinese...
Published on Sep 1, 2018in South African Journal of Botany 1.50
A.A. Ajao1
Estimated H-index: 1
(UJ: University of Johannesburg),
N.P. Sibiya (UJ: University of Johannesburg), A. Moteetee6
Estimated H-index: 6
(UJ: University of Johannesburg)
Abstract Sexual dysfunction is a serious health challenge characterized by inability to achieve, keep, and maintain penile erection enough for stimulating coitus. Literature suggests that many people suffering from sexual dysfunction continue to explore aphrodisiac plants as alternative therapy. However, the extent to which these plants are used across the sub-Saharan region is not known. The aim of this paper is therefore to present a review of aphrodisiac medicinal plants used for the treatmen...
Published on Feb 14, 2019in The Natural Products Journal
Mohammed Azeemuddin Mukhram (The Himalaya Drug Company), Mohamed Rafiq4
Estimated H-index: 4
(The Himalaya Drug Company)
+ 4 AuthorsRangesh Paramesh1
Estimated H-index: 1
(The Himalaya Drug Company)
Majid Nimrouzi7
Estimated H-index: 7
(Shiraz University of Medical Sciences),
Amir-Mohammad Jaladat1
Estimated H-index: 1
(Shiraz University of Medical Sciences),
Mohammad M. Zarshenas13
Estimated H-index: 13
(Shiraz University of Medical Sciences)
Abstract Erectile dysfunction (ED) and impotence are common male sexual problems, and they are highly prevalent in male adults with a history of hypertension or diabetes mellitus. This review aims to bring together the standpoints of the early Persian physicians on these disorders and to identify the respective medication in comparison with conventional contemporary medicine. The main medical and pharmaceutical manuscripts of traditional Persian medicine (TPM) are from 9th–18th century AD. Besid...
Published on Dec 1, 2017in Journal of Sport and Health Science 3.64
Yiming Ma1
Estimated H-index: 1
(SUS: Shanghai University of Sport),
Zhicheng Guo1
Estimated H-index: 1
(SUS: Shanghai University of Sport),
Xiaohui Wang1
Estimated H-index: 1
(SUS: Shanghai University of Sport)
Abstract Purpose To investigate the effects of Tribulus terrestris (TT) extracts on muscle mass, muscle damage, and anaerobic performances of trained male boxers and its mechanisms: roles of plasma androgen, insulin growth factor 1 (IGF-1), and IGF-1 binding protein-3 (IGFBP-3). Methods Fifteen male boxers were divided into exercise group (E, n = 7) and exercise plus TT group (E + TT, n = 8). The 2 groups both undertook 3-week high-intensity and 3-week high-volume trainings separated by a 4-week...
Sara Khaleghi1
Estimated H-index: 1
(Kermanshah University of Medical Sciences),
Mitra Bakhtiari4
Estimated H-index: 4
(Kermanshah University of Medical Sciences)
+ 1 AuthorsFarzane Esmaeili1
Estimated H-index: 1
(Kermanshah University of Medical Sciences)
Objective.The object of present study was to investigate the effects of direct addition of Tribulus terrestris extract on human sperm parameters.Design.Semen specimens from 40 healthy men volunteers were divided into 4 groups: one group received no treatment (control group) while the others were incubated with 20, 40, and 50 µg/mL of T terrestris extract (experimental groups). Motility, viability, and DNA fragmentation were assessed in all groups.Results.The incubation of human semen with 40 and...
Published on Jun 1, 2017in Andrologia 1.84
R. M. Salgado1
Estimated H-index: 1
,
M. H. Marques-Silva1
Estimated H-index: 1
+ 3 AuthorsP. Wolff1
Estimated H-index: 1
Summary Male fertility can be evaluated through complete semen analysis. Plants belonging to the Tribulus genus are known for their role in enhancing sex hormone levels and semen quality. The aim of this study was to evaluate the effects of T. terrestris on semen quality and physiological parameters. Sixty-five men with abnormal semen evaluation were included in this study, in which they were prescribed with oral administration of Androsten® (250 mg of Tribulus terrestris dried extract per capsu...
Published on Apr 1, 2017in Andrologia 1.84
Manal A. Abbas5
Estimated H-index: 5
(Al-Ahliyya Amman University)
Summary Male sexual dysfunction is a serious problem which has an impact on the quality of life. In Jordanian folk medicine, 56 plant species were reported to be used by males to improve sexual potency and as aphrodisiacs. The aim of this study was to search for scientific evidence justifying their folk use. Of the 15 studied plants, only five were found to enhance spermatogenesis. The other 10 were reported to decrease spermatogenesis at least by one study. The majority of the studied plants po...