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Journal of Pharmacology and Pharmacotherapeutics
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#1Samarjit Dey (All India Institute of Medical Sciences Raipur)H-Index: 1
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Objective: To evaluate the safety and efficacy of dexmedetomidine versus propofol as a sedative modality for awake fiber-optic intubation (AFOI) in elective patients with anticipated difficult intubation. Materials and Methods: This randomized prospective study was conducted on 90 patients (Group D and Group P; n = 45) who had undergone AFOI for anticipated difficult airway. Group D received intravenous (IV) dexmedetomidine and Group P patients received IV propofol, until they were adequately se...
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Objective: To evaluate the anticonvulsant and antioxidant actions of diltiazem, nimodipine, and flunarizine in the Wistar albino rats using the maximum electroshock-induced seizure (MES) model. Materials and Methods: Thirty inbred Wistar rats were divided into five groups of six rats in each group. Groups 3, 4, and 5 were pretreated with diltiazem (20 mg/kg), nimodipine (20 mg/kg), and flunarizine (10 mg/kg), respectively. Group 2 served as a standard group and received phenytoin (25 mg/kg). All...
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Objective: To evaluate and compare the adherence of the ARRIVE guidelines before and after its introduction by the articles published by two leading journals publishing animal research articles. Materials and Methods: Literature of original research articles of animal studies was obtained from two leading open-access journals. A combined total of 100 articles were selected from these journals from the years 2009 and 2016 (50 articles from each year). Each article was assessed by two investigator...
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Valproate, a commonly used antiepileptic, is known to cause pancreatitis, which may present days to years after initiation of therapy. A 20-year-old Arab male patient with electroencephalogram (EEG) confirmed epileptiform activity over the left posterior head region was initiated with tablet carbamazepine 400 mg twice daily in the year 2015 and based on subsequent EEG findings (suggestive of more of generalized myoclonic seizure) carbamazepine was withdrawn gradually and started with sodium valp...
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Aim: To investigate the myocardial preconditioning potential of hedgehog activator smoothened (SMO) receptor agonist purmorphamine (PUR) against ischemia-reperfusion (I/R) injury in deoxycortisone acetate (DOCA) salt-induced hypertensive rat heart. Methods: Hypertension in rats was produced by surgical removal of the kidney and DOCA salt administration for 6 weeks. Isolated rat heart was subjected to 30 min ischemia followed by 120 min of I/R. The heart was subjected to pharmacological precondit...
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#1Chandini Rao (Father Muller Medical College)
#2Varadaraj Shenoy (Father Muller Medical College)
Last.Padmaja Udaykumar (Father Muller Medical College)H-Index: 2
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Aim: To identify and evaluate the potential drug–drug interactions (PDDI) in hospitalized patients in a pediatric intensive care unit (PICU). Materials and Methods: In this cross-sectional observational study, we analyzed prescriptions of children aged 1 month–15 years admitted to PICU for PDDIs, and categorized them based on the severity (mild, moderate, and severe), underlying mechanisms, number of concomitant drugs used and potential outcomes of these PDDIs, using a drug interaction checking ...
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#1Shalini Chawla (MAMC: Maulana Azad Medical College)H-Index: 7
#2Ankur Tiwari (MAMC: Maulana Azad Medical College)
Last.Shariq Naeem Syed (Jawaharlal Nehru Medical College, Aligarh)
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Aim: To assess the patterns of dermatological adverse drug reactions (ADRs) and drugs responsible to formulate a strategy for prevention and treatment using a new app. Materials and Methods: In the present study, 870 patients in dermatology outpatient department were screened, out of which sixty cutaneous ADRs were included in the study. The ADRs were categorized and assessed by Causality Assessment Scale and Preventability Scale using an innovative mobile software application named “Pharmvigill...
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The use of systemic and topical steroids, amiodarone, and phenothiazines has been established as risk factors for the development of cataract. Antihistaminics are commonly prescribed drugs for a wide range of allergic disorders but have rarely been associated with cataract formation. We herewith report cases of two young males who were on long-term antihistaminics for allergic conditions and presented with blurring of vision. Slit lamp examination revealed bilateral posterior subcapsular catarac...
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#1Karri Sowjanya (JIPMER: Jawaharlal Institute of Postgraduate Medical Education and Research)
#2C. Girish (JIPMER: Jawaharlal Institute of Postgraduate Medical Education and Research)H-Index: 10
Structural genomics, technology and methodology driven field has emerged in the past 20–25 years and mainly aims at coming up with as many three-dimensional structures of proteins as possible by combining experimental (X-ray crystallography and nuclear magnetic resonance) and comparative modeling methods at a minimal cost in comparison to the traditional approaches. Structure aided drug discovery which is used since long mainly focuses on a single target protein whereas structural genomics targe...
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