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Vinod Nair
All India Institute of Medical Sciences
18Publications
9H-index
236Citations
Publications 18
Newest
Published on Sep 1, 2017in International Journal of Rheumatic Diseases 1.94
Rohit Kumar5
Estimated H-index: 5
(AIIMS: All India Institute of Medical Sciences),
Vinod Nair9
Estimated H-index: 9
(AIIMS: All India Institute of Medical Sciences)
+ 1 AuthorsSurender Singh25
Estimated H-index: 25
(AIIMS: All India Institute of Medical Sciences)
Aim The present study was carried out to evaluate the anti-inflammatory and antiarthritic activity of Rosa centifolia aqueous extract (RC) in a carrageenan-induced paw edema model and complete Freund's adjuvant (CFA)-induced arthritis. Methods Anti-inflammatory activity of RC was evaluated using the carrageenan-induced paw edema model in rats. Arthritis was induced in rats by sub-plantar administration of CFA. Joint size was measured at regular intervals by using a micrometer screw gauge. Serum ...
Published on Aug 17, 2016in Immunological Investigations 2.69
Rohit Kumar5
Estimated H-index: 5
(AIIMS: All India Institute of Medical Sciences),
Vinod Nair9
Estimated H-index: 9
(AIIMS: All India Institute of Medical Sciences)
+ 2 AuthorsS. Arunraja3
Estimated H-index: 3
ABSTRACTThe present study was carried out to investigate the anti-arthritic activity of Berberis aristata hydroalcoholic extract (BAHE) in formaldehyde-induced arthritis and adjuvant-induced arthritis (AIA) model. Arthritis was induced by administration of either formaldehyde (2% v/v) or CFA into the subplantar surface of the hind paw of the animal. In formaldehyde-induced arthritis and AIA, treatment of BAHE at doses 50, 100 and 200 mg/kg orally significantly decreased joint inflammation as evi...
Rohit Kumar5
Estimated H-index: 5
,
Vinod Nair9
Estimated H-index: 9
+ 1 AuthorsYogendra Kumar Gupta34
Estimated H-index: 34
Introduction: Rosa centifolia L. (Rosaceae) have been used for the treatment of joint pain and rheumatoid arthritis (RA) in the traditional system of medicine. Aim : In this study, the antiarthritic activity of the alcoholic extract from the floral parts of R. centifolia was investigated. Materials and Methods: The anti-inflammatory and antiarthritic activity of R. centifolia alcoholic extract (RCAE: 32, 64, and 128 mg/kg) was evaluated using the carrageenan-induced paw edema and complete Freund...
Published on Oct 1, 2013in Journal of Enzyme Inhibition and Medicinal Chemistry 4.03
Syed Ovais8
Estimated H-index: 8
(Hamdard University),
Shafiya Yaseen7
Estimated H-index: 7
(Hamdard University)
+ 5 AuthorsKalim Javed5
Estimated H-index: 5
(Hamdard University)
Nine novel 4-[3-(4-Dimethylamino-phenyl)-5-aryl-4,5-dihydro-pyrazol-1-yl]-benzenesulfonamides (2a-i) were synthesized and evaluated for their anti-inflammatory and antiproliferative activities. These compounds (2a-i) showed moderate to strong anti-inflammatory activity in carrageenan rat paw oedema test. Compounds 2b, 2d and 2g showing comparable anti-inflammatory activity to that of reference drug celecoxib were evaluated for their ulcerogenic and analgesic activities. The effect of 2b, 2d and ...
Published on Jun 1, 2013in Archiv Der Pharmazie 2.15
Shafiya Yaseen7
Estimated H-index: 7
(Hamdard University),
Syed Ovais8
Estimated H-index: 8
(Hamdard University)
+ 5 AuthorsKalim Javed5
Estimated H-index: 5
(Hamdard University)
Nine 4-arylphthalazones bearing benzenesulfonamide (2a–i) were synthesized by the condensation of the appropriate 2-aroylbenzoic acid (1a–i) and 4-hydrazinobenzenesulfonamide in ethanol. The structures of these compounds were elucidated by elemental analysis, IR, 1H NMR, 13C NMR, and MS spectroscopy. Two compounds, 2b and 2i, showed significant anti-inflammatory activity comparable to that of the standard drug celecoxib in the carrageenan-induced rat paw edema model. These compounds (2b and 2i) ...
Published on Apr 1, 2013in Medicinal Chemistry 2.53
Rafia Bashir7
Estimated H-index: 7
,
Kalim Javed5
Estimated H-index: 5
+ 7 AuthorsVinod Nair9
Estimated H-index: 9
Some unnatural chalcones (1a-q) and flavones (2a-d) have been synthesized and evaluated for their antiinflammatory activity using carrageenan-induced rat paw edema assay. The flavone 2c (6-Chloro-7-methyl-3', 4'- dimethoxyflavone) had higher anti-inflammatory activity and superior gastrointestinal safety profiles than the reference drug celecoxib. Compound 2c showed almost two times better selective inhibitory activity towards COX-2 enzyme than celecoxib. 2'-Hydroxychalcones (1a-h) showed modera...
Vinod Nair9
Estimated H-index: 9
(AIIMS: All India Institute of Medical Sciences),
Surender Singh25
Estimated H-index: 25
(AIIMS: All India Institute of Medical Sciences),
Yogendra Kumar Gupta34
Estimated H-index: 34
(AIIMS: All India Institute of Medical Sciences)
Background: Coriandrum sativum has been used in the traditional systems of medicine for management of arthritis and other inflammatory disorders. Objectives: In this study, we have evaluated the anti-inflammatory and anti-granuloma activities of Coriandrum sativum hydroalcoholic extract (CSHE) in experimental models. Materials and Methods: The anti-inflammatory activity of CSHE was evaluated using carrageenan-induced paw edema model and the anti-granuloma activity of CSHE was evaluated using the...
Published on Aug 1, 2012in European Journal of Inflammation
Vinod Nair9
Estimated H-index: 9
,
Rohit Kumar5
Estimated H-index: 5
+ 1 AuthorsYogendra Kumar Gupta34
Estimated H-index: 34
Published on Jun 1, 2012in Inflammation 2.94
Vinod Nair9
Estimated H-index: 9
(AIIMS: All India Institute of Medical Sciences),
Rohit Kumar5
Estimated H-index: 5
(AIIMS: All India Institute of Medical Sciences)
+ 1 AuthorsYogendra Kumar Gupta34
Estimated H-index: 34
(AIIMS: All India Institute of Medical Sciences)
The present study evaluates the anti-inflammatory and antigranuloma activity of CLHE in experimental models, viz. carrageenan-induced paw edema, subcutaneous cotton pellet implantation-induced granuloma formation, and complete Freund's adjuvant-induced stimulation of peritoneal macrophages in rats. Serum TNF-alpha, IL-6, and IL-1 beta levels were estimated as markers for global effects of inflammation. TNF-R1 protein expression was estimated in stimulated peritoneal macrophages. There was a sign...
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