Original paper
Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9
Abstract
The CRISPR/Cas9 system has been proven to be an efficient gene-editing tool for genome modification of cells and organisms. Multiplex genetic engineering in rat holds a bright future for the study of complex disease. Here, we show that this system enables the simultaneous disruption of four genes (ApoE, B2m, Prf1, and Prkdc) in rats in one-step, by co-injection of Cas9 mRNA and sgRNAs into fertilized eggs. We further observed the gene...
Paper Details
Title
Heritable Multiplex Genetic Engineering in Rats Using CRISPR/Cas9
Published Date
Mar 5, 2014
Journal
Volume
9
Issue
3
Pages
e89413 - e89413
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Notes
History