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Bin Shen
Nanjing Medical University
36Publications
14H-index
1,698Citations
Publications 36
Newest
Published on May 15, 2019in Development 5.41
Shun Bai3
Estimated H-index: 3
,
Kaiqiang Fu1
Estimated H-index: 1
+ 20 AuthorsYueshuai Guo10
Estimated H-index: 10
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Published on Apr 1, 2019in Nature 41.58
Dali Han11
Estimated H-index: 11
(Chinese Academy of Sciences),
Jun Liu1
Estimated H-index: 1
(University of Chicago)
+ 12 AuthorsUrszula Dougherty16
Estimated H-index: 16
(University of Chicago)
In this Letter, a citation to ‘Fig. 1e’ has been corrected to ‘Fig. 1d’ in the sentence starting “By contrast, the anti-tumour response…”. This has been corrected online
1 Citations Source Cite
Published on Mar 25, 2019in bioRxiv
Yongchang Chen11
Estimated H-index: 11
(Kunming University of Science and Technology),
Puhao Xiao1
Estimated H-index: 1
(Kunming University of Science and Technology)
+ 12 AuthorsShuaiwei Ren1
Estimated H-index: 1
(Kunming University of Science and Technology)
The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy. However, pre-existing adaptive immune responses against CRISPR nuclease (PAIR-C) and AAVs has been found in human serum, indicating that immune response is a problem that cannot be ignored, especially for in vivo gene correction. Non-human primates...
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Published on Mar 18, 2019in Nucleic Acids Research 11.56
Zhuojia Chen1
Estimated H-index: 1
(University of Chicago),
Meijie Qi1
Estimated H-index: 1
(Nanjing Medical University)
+ 7 AuthorsHongsheng Wang1
Estimated H-index: 1
(University of Chicago)
1 Citations Source Cite
Published on Mar 1, 2019in Oncogene 6.85
Cheng Wang13
Estimated H-index: 13
,
Yayun Gu6
Estimated H-index: 6
(Nanjing Medical University)
+ 23 AuthorsYue Jiang18
Estimated H-index: 18
(Nanjing Medical University)
Our previous work found cancer-testis (CT) genes as a new source of epi-driver candidates of cancer. LIN28B was a CT gene, but the “driver” ability and the activation mechanism in lung adenocarcinoma (LUAD) remain unclear. We observed that LIN28B expression was restricted in testis. It was re-activated in LUAD patients without known genomic alterations in oncogenes and was related to poorer survival. In vitro and In vivo experiments confirmed that the activation of LIN28B could promote the proli...
3 Citations Source Cite
Published on Feb 1, 2019in Nature 41.58
Dali Han11
Estimated H-index: 11
(Chinese Academy of Sciences),
Jun Liu1
Estimated H-index: 1
(University of Chicago)
+ 12 AuthorsUrszula Dougherty16
Estimated H-index: 16
(University of Chicago)
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies1,2. Despite the presence of numerous neoantigens in patients, complete tumour elimination is rare, owing to failures in mounting a sufficient and lasting antitumour immune response3,4. Here we show that durable neoantigen-specific immunity is regulated by mRNA N6-methyadenosine (m6A) methylation through the m6A-binding p...
6 Citations Source Cite
Published on Dec 1, 2018in Cell discovery
Yanan Yue1
Estimated H-index: 1
(Zhejiang University),
Jun Liu1
Estimated H-index: 1
(Howard Hughes Medical Institute)
+ 14 AuthorsHonghui Ma1
Estimated H-index: 1
(Howard Hughes Medical Institute)
N6-methyladenosine (m6A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, however. Herein we report a characterization of the full m6A methyltransferase complex in HeLa cells identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and we show that VIRMA mediates prefer...
25 Citations Source Cite
Published on Nov 1, 2018in Nature 41.58
Hailing Shi11
Estimated H-index: 11
,
Xuliang Zhang1
Estimated H-index: 1
(ShanghaiTech University)
+ 19 AuthorsFeng Zhang1
Estimated H-index: 1
(University of Pennsylvania)
N6-methyladenosine (m6A), the most prevalent internal RNA modification on mammalian messenger RNAs, regulates the fates and functions of modified transcripts through m6A-specific binding proteins1–5. In the nervous system, m6A is abundant and modulates various neural functions6–11. Whereas m6A marks groups of mRNAs for coordinated degradation in various physiological processes12–15, the relevance of m6A for mRNA translation in vivo remains largely unknown. Here we show that, through its binding ...
11 Citations Source Cite
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