Bin Shen
Nanjing Medical University
Publications 36
#1Lipei Shao (Nanjing Medical University)H-Index: 3
#2Xianglin Zuo (Nanjing Medical University)
Last.Guangfu Jin (Nanjing Medical University)H-Index: 35
view all 20 authors...
Inherited factors contribute to lung cancer risk, but the mechanism is not well understood. Defining the biological consequence of GWAS hits in cancers is a promising strategy to elucidate the inherited mechanisms of cancers. The tag-SNP rs753955 (A>G) in 13q12.12 is highly associated with lung cancer risk in the Chinese population. Here, we systematically investigate the biological significance and the underlying mechanism behind 13q12.12 risk locus in vitro and in vivo. We characterize a novel...
#1Jianye Wang (SJTU: Shanghai Jiao Tong University)
#2Bian Hu (ShanghaiTech University)
Last.Xingxu Huang (ShanghaiTech University)H-Index: 14
view all 12 authors...
Endoplasmic reticulum (ER) stress-associated cell death is prevalent in various liver diseases. However, the determinant mechanism how hepatocytes survive unresolved stress was still unclear. Interleukin-24 (IL-24) was previously found to promote ER stress-mediated cell death, and yet its expression and function in the liver remained elusive. Here we identified an anti-apoptotic role of IL-24, which transiently accumulated within ER-stressed hepatocytes in a X-box binding protein 1 (XBP1)-depend...
#1Dali Han (CAS: Chinese Academy of Sciences)H-Index: 11
#2Jun Liu (U of C: University of Chicago)H-Index: 1
Last.Urszula Dougherty (U of C: University of Chicago)H-Index: 16
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In this Letter, a citation to ‘Fig. 1e’ has been corrected to ‘Fig. 1d’ in the sentence starting “By contrast, the anti-tumour response…”. This has been corrected online
#1Yongchang Chen (Kunming University of Science and Technology)H-Index: 11
#2Puhao Xiao (Kunming University of Science and Technology)H-Index: 1
Last.Shuaiwei Ren (Kunming University of Science and Technology)H-Index: 1
view all 15 authors...
The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy. However, pre-existing adaptive immune responses against CRISPR nuclease (PAIR-C) and AAVs has been found in human serum, indicating that immune response is a problem that cannot be ignored, especially for in vivo gene correction. Non-human primates...
#1Zhuojia Chen (U of C: University of Chicago)H-Index: 1
#2Meijie Qi (Nanjing Medical University)H-Index: 1
Last.Qing Dai (U of C: University of Chicago)H-Index: 40
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#1Cheng WangH-Index: 13
#2Yayun Gu (Nanjing Medical University)H-Index: 6
Last.Yue Jiang (Nanjing Medical University)H-Index: 18
view all 26 authors...
Our previous work found cancer-testis (CT) genes as a new source of epi-driver candidates of cancer. LIN28B was a CT gene, but the “driver” ability and the activation mechanism in lung adenocarcinoma (LUAD) remain unclear. We observed that LIN28B expression was restricted in testis. It was re-activated in LUAD patients without known genomic alterations in oncogenes and was related to poorer survival. In vitro and In vivo experiments confirmed that the activation of LIN28B could promote the proli...
#1Dali Han (CAS: Chinese Academy of Sciences)H-Index: 11
#2Jun Liu (U of C: University of Chicago)H-Index: 1
Last.Urszula Dougherty (U of C: University of Chicago)H-Index: 16
view all 15 authors...
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies1,2. Despite the presence of numerous neoantigens in patients, complete tumour elimination is rare, owing to failures in mounting a sufficient and lasting antitumour immune response3,4. Here we show that durable neoantigen-specific immunity is regulated by mRNA N6-methyadenosine (m6A) methylation through the m6A-binding p...
#1Yanan Yue (ZJU: Zhejiang University)H-Index: 1
#2Yanan Yue (ZJU: Zhejiang University)
Last.Zezhou Zhang (ZJU: Zhejiang University)H-Index: 3
view all 17 authors...
N6-methyladenosine (m6A) is enriched in 3′untranslated region (3′UTR) and near stop codon of mature polyadenylated mRNAs in mammalian systems and has regulatory roles in eukaryotic mRNA transcriptome switch. Significantly, the mechanism for this modification preference remains unknown, however. Herein we report a characterization of the full m6A methyltransferase complex in HeLa cells identifying METTL3/METTL14/WTAP/VIRMA/HAKAI/ZC3H13 as the key components, and we show that VIRMA mediates prefer...