Bin Shen
Nanjing Medical University
35Publications
14H-index
1,583Citations
Publications 35
Newest
Published on Mar 25, 2019in Nature 41.58
Dali Han16
Estimated H-index: 16
(Chinese Academy of Sciences),
Jun Liu1
Estimated H-index: 1
(University of Chicago)
+ 12 AuthorsUrszula Dougherty16
Estimated H-index: 16
(University of Chicago)
In this Letter, a citation to ‘Fig. 1e’ has been corrected to ‘Fig. 1d’ in the sentence starting “By contrast, the anti-tumour response…”. This has been corrected online
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Published on Mar 1, 2019in Oncogene 6.85
Cheng Wang26
Estimated H-index: 26
,
Yayun Gu5
Estimated H-index: 5
(Nanjing Medical University)
+ 23 AuthorsYue Jiang19
Estimated H-index: 19
(Nanjing Medical University)
Our previous work found cancer-testis (CT) genes as a new source of epi-driver candidates of cancer. LIN28B was a CT gene, but the “driver” ability and the activation mechanism in lung adenocarcinoma (LUAD) remain unclear. We observed that LIN28B expression was restricted in testis. It was re-activated in LUAD patients without known genomic alterations in oncogenes and was related to poorer survival. In vitro and In vivo experiments confirmed that the activation of LIN28B could promote the proli...
2 Citations Source Cite
Published on Mar 18, 2019in Nucleic Acids Research 11.56
Zhuojia Chen (University of Chicago), Meijie Qi (Nanjing Medical University)+ 7 AuthorsHongsheng Wang (University of Chicago)
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Published on Feb 1, 2019in Nature 41.58
Dali Han16
Estimated H-index: 16
(Chinese Academy of Sciences),
Jun Liu1
Estimated H-index: 1
(University of Chicago)
+ 12 AuthorsUrszula Dougherty16
Estimated H-index: 16
(University of Chicago)
There is growing evidence that tumour neoantigens have important roles in generating spontaneous antitumour immune responses and predicting clinical responses to immunotherapies1,2. Despite the presence of numerous neoantigens in patients, complete tumour elimination is rare, owing to failures in mounting a sufficient and lasting antitumour immune response3,4. Here we show that durable neoantigen-specific immunity is regulated by mRNA N6-methyadenosine (m6A) methylation through the m6A-binding p...
1 Citations Source Cite
Published on Mar 25, 2019in bioRxiv
Yongchang Chen12
Estimated H-index: 12
(Kunming University of Science and Technology),
Puhao Xiao1
Estimated H-index: 1
(Kunming University of Science and Technology)
+ 12 AuthorsShuaiwei Ren1
Estimated H-index: 1
(Kunming University of Science and Technology)
The CRISPR-mediated Cas system is the most widely used tool in gene editing and gene therapy for its convenience and efficiency. Delivery of the CRISPR system by adeno-associated viruses (AAVs) is currently the most promising approach to gene therapy. However, pre-existing adaptive immune responses against CRISPR nuclease (PAIR-C) and AAVs has been found in human serum, indicating that immune response is a problem that cannot be ignored, especially for in vivo gene correction. Non-human primates...
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Published on Jan 1, 2018in Nature Structural & Molecular Biology 13.33
Liqun Lei2
Estimated H-index: 2
(Chinese Academy of Sciences),
Hongquan Chen1
Estimated H-index: 1
(Wenzhou Medical College)
+ 16 AuthorsJianying Wang9
Estimated H-index: 9
(Nanjing Medical University)
The APOBEC-AID family of cytidine deaminase prefers single-stranded nucleic acids for cytidine-to-uridine deamination. Single-stranded nucleic acids are commonly involved in the DNA repair system for breaks generated by CRISPR–Cas9. Here, we show in human cells that APOBEC3 can trigger cytidine deamination of single-stranded oligodeoxynucleotides, which ultimately results in base substitution mutations in genomic DNA through homology-directed repair (HDR) of Cas9-generated double-strand breaks. ...
5 Citations Source Cite
Published on Jul 1, 2018in Development 5.41
Shun Bai2
Estimated H-index: 2
(Nanjing Medical University),
Kaiqiang Fu1
Estimated H-index: 1
(Nanjing Medical University)
+ 20 AuthorsYueshuai Guo10
Estimated H-index: 10
(Nanjing Medical University)
Transcription factors of the Sox protein family contain a DNA-binding HMG box and are key regulators of progenitor cell fate. Here, we report that expression of Sox30 is restricted to meiotic spermatocytes and postmeiotic haploids. Sox30 mutant males are sterile due to spermiogenic arrest at the early round spermatid stage. Specifically, in the absence of Sox30, proacrosomic vesicles fail to form a single acrosomal organelle, and spermatids arrest at step 2-3. Although most Sox30 mutant spermato...
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Published on Oct 1, 2018in Cell Research 15.39
Zhenrui Li2
Estimated H-index: 2
(Stowers Institute for Medical Research),
Pengxu Qian1
Estimated H-index: 1
(Zhejiang University)
+ 28 AuthorsYunfei Zhu3
Estimated H-index: 3
(Nanjing Medical University)
In the initial published version of this article, there was an inadvertent omission from the Acknowledgements that this work was supported by Stowers Institute for Medical Research (SIMR-1004) and NIH National Cancer Institute grant to University of Kansas Cancer Center (P30 CA168524). This omission does not affect the description of the results or the conclusions of this work.
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Published on Oct 1, 2018in Cell Research 15.39
Hu Wang1
Estimated H-index: 1
(Jinan University),
Hongna Zuo1
Estimated H-index: 1
(Hangzhou Normal University)
+ 9 AuthorsGang Huang1
Estimated H-index: 1
(Cincinnati Children's Hospital Medical Center)
1 Citations Source Cite
Published on Jan 1, 2018in Neuron 14.32
Yi-Lan Weng1
Estimated H-index: 1
(University of Pennsylvania),
Xu Wang1
Estimated H-index: 1
(Hong Kong University of Science and Technology)
+ 19 AuthorsSamuel Zheng Hao Wong1
Estimated H-index: 1
(University of Pennsylvania)
Summary N 6 -methyladenosine (m 6 A) affects multiple aspects of mRNA metabolism and regulates developmental transitions by promoting mRNA decay. Little is known about the role of m 6 A in the adult mammalian nervous system. Here we report that sciatic nerve lesion elevates levels of m 6 A-tagged transcripts encoding many regeneration-associated genes and protein translation machinery components in the adult mouse dorsal root ganglion (DRG). Single-base resolution m 6 A-CLIP mapping further reve...
28 Citations Source Cite
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