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Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function.

Published on Jun 1, 2008in Obesity3.97
· DOI :10.1038/oby.2008.201
D. Enette Larson-Meyer21
Estimated H-index: 21
(UW: University of Wyoming),
Bradley R. Newcomer24
Estimated H-index: 24
(UAB: University of Alabama at Birmingham)
+ 7 AuthorsEric Ravussin99
Estimated H-index: 99
(LSU: Louisiana State University)
Cite
Abstract
D. Enette Larson-Meyer, Bradley R. Newcomer, Leonie K. Heilbronn, Julia Volaufova, Steven R. Smith, Anthony J. Alfonso, Michael Lefevre, Jennifer C. Rood, Donald A. Williamson, Eric Ravussin and The Pennington CALERIE Team
  • References (41)
  • Citations (136)
Cite
References41
Newest
Published on May 1, 2007in Diabetes Care15.27
Giovanni Targher17
Estimated H-index: 17
,
Lorenzo Bertolini29
Estimated H-index: 29
+ 5 AuthorsGuido Arcaro8
Estimated H-index: 8
OBJECTIVE —To determine the prevalence of nonalcoholic fatty liver disease (NAFLD) in type 2 diabetic population and to compare the prevalence of cardiovascular disease (CVD) and its risk factors between people with and without NAFLD. RESEARCH DESIGN AND METHODS —The entire sample of type 2 diabetic outpatients ( n = 2,839) who regularly attended our clinic was screened. Main outcome measures were NAFLD (by patient history and liver ultrasound) and manifest CVD (by patient history, review of pat...
Published on Mar 1, 2007in The Journal of Clinical Endocrinology and Metabolism5.61
Leanne M. Redman38
Estimated H-index: 38
(Pennington Biomedical Research Center),
Leonie K. Heilbronn37
Estimated H-index: 37
(Pennington Biomedical Research Center)
+ 3 AuthorsEric Ravussin99
Estimated H-index: 99
(Pennington Biomedical Research Center)
Context: There is debate over the independent and combined effects of dieting and increased physical activity on improving metabolic risk factors (body composition and fat distribution). Objective: The objective of the study was to conduct a randomized, controlled trial (CALERIE) to test the effect of a 25% energy deficit by diet alone or diet plus exercise for 6 months on body composition and fat distribution. Design: This was a randomized, controlled trial. Setting: The study was conducted at ...
Published on Jun 1, 2006in Diabetes Care15.27
D. Enette Larson-Meyer21
Estimated H-index: 21
,
Leonie K. Heilbronn37
Estimated H-index: 37
+ 6 AuthorsEric Ravussin99
Estimated H-index: 99
OBJECTIVE —The purpose of this article was to determine the relationships among total body fat, visceral adipose tissue (VAT), fat cell size (FCS), ectopic fat deposition in liver (intrahepatic lipid [IHL]) and muscle (intramyocellular lipid [IMCL]), and insulin sensitivity index ( S i ) in healthy overweight, glucose-tolerant subjects and the effects of calorie restriction by diet alone or in conjunction with exercise on these variables. RESEARCH DESIGN AND METHODS —Forty-eight overweight volun...
Published on Apr 5, 2006in JAMA51.27
Leonie K. Heilbronn37
Estimated H-index: 37
(Pennington Biomedical Research Center),
Lilian de Jonge23
Estimated H-index: 23
+ 12 AuthorsMarlene M. Most14
Estimated H-index: 14
ContextProlonged calorie restriction increases life span in rodents. Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans.ObjectiveTo examine the effects of 6 months of calorie restriction, with or without exercise, in overweight, nonobese (body mass index, 25 to <30) men and women.Design, Setting, and ParticipantsRandomized controlled t...
Published on Jan 1, 2006in Obesity3.97
D. Enette Larson-Meyer21
Estimated H-index: 21
(UW: University of Wyoming),
Steven R. Smith71
Estimated H-index: 71
(Pennington Biomedical Research Center)
+ 3 AuthorsBradley R. Newcomer24
Estimated H-index: 24
(UAB: University of Alabama at Birmingham)
Objective: Muscle triglyceride can be assessed in vivo using computed tomography (CT) and 1H magnetic resonance spectroscopy (MRS), two techniques that are based on entirely different biophysical principles. Little is known, however, about the cross-correlation between these techniques and their test—retest reliability. Research Methods and Procedures: We compared mean muscle attenuation (MA) in soleus and tibialis anterior (TA) muscles measured by CT with intra- and extramyocellular lipids (IMC...
Published on Nov 1, 2005in The American Journal of Clinical Nutrition6.57
Michael Lefevre34
Estimated H-index: 34
(Pennington Biomedical Research Center),
Catherine M. Champagne49
Estimated H-index: 49
(Pennington Biomedical Research Center)
+ 2 AuthorsMarlene M. Most14
Estimated H-index: 14
(Pennington Biomedical Research Center)
Background: Although reductions in total and saturated fat consumption are recommended to reduce the risk of cardiovascular disease, individual variability in plasma lipid responses exists. Objective: Our aim was to determine the effect of adiposity and insulin resistance on the lipoprotein response to diets lower in total and saturated fat than the average American diet (AAD). Design:Arandomized,double-blind,3-periodcrossovercontrolled feeding design was used to examine the effects on plasma li...
Published on Jul 1, 2005in Obesity Research
Yung-Hsuan Shen1
Estimated H-index: 1
(NTU: National Taiwan University),
Wei-Shiung Yang37
Estimated H-index: 37
(NTU: National Taiwan University)
+ 3 AuthorsKuo-Chin Huang40
Estimated H-index: 40
(NTU: National Taiwan University)
SHEN, YUNG-HSUAN, WEI-SHIUNG YANG, TZONGHSI LEE, LONG-TENG LEE, CHING-YU CHEN, AND KUO-CHIN HUANG. Bright liver and alanine aminotransferase are associated with metabolic syndrome in adults. Obes Res. 2005;13:1238–1245. Objectives: The metabolic syndrome has become a significant health problem worldwide. In this study, we investigated the relationship between the metabolic syndrome, bright liver (BL) by ultrasonography (US), and plasma alanine aminotransferase (ALT) levels among apparently healt...
Published on Jul 1, 2005in Diabetes Care15.27
Ronald B. Goldberg51
Estimated H-index: 51
(UM: University of Miami),
David M. Kendall33
Estimated H-index: 33
+ 7 AuthorsScott J. Jacober25
Estimated H-index: 25
(Eli Lilly and Company)
OBJECTIVE —Published reports suggest that pioglitazone and rosiglitazone have different effects on lipids in patients with type 2 diabetes. However, these previous studies were either retrospective chart reviews or clinical trials not rigorously controlled for concomitant glucose- and lipid-lowering therapies. This study examines the lipid and glycemic effects of pioglitazone and rosiglitazone. RESEARCH DESIGN AND METHODS —We enrolled subjects with a diagnosis of type 2 diabetes (treated with di...
Lidia S. Szczepaniak26
Estimated H-index: 26
(UTSW: University of Texas Southwestern Medical Center),
Pamela Nurenberg8
Estimated H-index: 8
(UTSW: University of Texas Southwestern Medical Center)
+ 5 AuthorsRobert L. Dobbins21
Estimated H-index: 21
(UTSW: University of Texas Southwestern Medical Center)
Despite the increasing prevalence of nonalcoholic fatty liver disease (NAFLD), the criteria used to diagnose the disorder remain poorly defined. Localized proton magnetic resonance spectroscopy (MRS) accurately measures hepatic triglyceride content (HTGC) but has been used only in small research studies. Here, MRS was used to analyze the distribution of HTGC in 2,349 participants from the Dallas Heart Study (DHS). The reproducibility of the procedure was validated by showing that duplicate HTGC ...
Published on Jan 1, 2005in Tohoku Journal of Experimental Medicine1.58
Mototsugu Ishii6
Estimated H-index: 6
(Iwate Medical University),
Yoshichika Yoshioka20
Estimated H-index: 20
(Iwate Medical University)
+ 9 AuthorsMasakatsu Iwai5
Estimated H-index: 5
(Iwate Medical University)
We measured liver fat content by 3-Tesla magnetic resonance spectroscopy (MRS) in 34 non- to mild obese Japanese subjects with type 2 diabetes, who were not complicated with any liver diseases including clinical fatty liver (liver/spleen ratio of computed tomography [CT] < 0.9) and were not being treated with oral hypoglycemic agents, insulin, or lipid-lowering agents, and analyzed the relationship between liver fat content and body composition and plasma metabolite. The liver fat content is sig...
Cited By136
Newest
Published on 2019in bioRxiv
Marian Beekman43
Estimated H-index: 43
(LUMC: Leiden University Medical Center),
Bianca A. M. Schutte2
Estimated H-index: 2
(LUMC: Leiden University Medical Center)
+ 7 AuthorsEdith J. M. Feskens77
Estimated H-index: 77
(WUR: Wageningen University and Research Centre)
SCOPE: Abdominal obesity is one of the main modifiable risk factors of age-related cardiometabolic disease. Cardiometabolic disease risk and its associated high abdominal fat mass, high cholesterol and glucose concentrations can be reduced by a healthier lifestyle. Hence, our aim is to understand the relation between lifestyle-induced changes in body composition, and specifically abdominal fat, and accompanying changes in circulating metabolic biomarkers. Methods and results: We used the data fr...
The purpose of this study was to examine the effects of a long-term community-based lifestyle intervention on the biochemical indicators and prevalence of metabolic syndrome among elderly adults. This was a randomized controlled trial in northern Taiwan from August 2013 to February 2015. Sixty-nine elderly adults participated in this study. There were three measurements. The experimental group participated in exercise and diet interventions. The control group participated in the exercise interve...
Published on Apr 1, 2019in Clinical Nutrition6.40
M. Plauth11
Estimated H-index: 11
,
William Bernal6
Estimated H-index: 6
(University of Cambridge)
+ 4 AuthorsStephan C. Bischoff60
Estimated H-index: 60
(University of Hohenheim)
Summary This update of evidence-based guidelines (GL) aims to translate current evidence and expert opinion into recommendations for multidisciplinary teams responsible for the optimal nutritional and metabolic management of adult patients with liver disease. The GL was commissioned and financially supported by ESPEN. Members of the guideline group were selected by ESPEN. We searched for meta-analyses, systematic reviews and single clinical trials based on clinical questions according to the PIC...
Published on Mar 7, 2019in World Journal of Gastroenterology3.41
Peter Deibert24
Estimated H-index: 24
,
Adhara Lazaro1
Estimated H-index: 1
+ 7 AuthorsThomas de Lange10
Estimated H-index: 10
Published on Feb 1, 2019in Nutrition3.59
Haruna Ishikawa2
Estimated H-index: 2
(Tohoku University),
Xiaoxu Guo2
Estimated H-index: 2
(Tohoku University)
+ 5 AuthorsTsuyoshi Tsuduki20
Estimated H-index: 20
(Tohoku University)
Abstract Objective Previous studies have demonstrated that obesity is rare among those who consume the Japanese diet because of its lower caloric content compared with the American diet. Meanwhile, it has been reported that maternal caloric restriction, which induces antiobesity effects, during pregnancy and lactation increases the likelihood of a low birthweight infant, which increases the risks for obesity and diabetes later in life. The aim of this study was to examine the influence of matern...
Published on Dec 18, 2018in Molecules3.06
Weiyao Liao1
Estimated H-index: 1
,
Xiaohan Yin1
Estimated H-index: 1
+ 5 AuthorsXiang Feng1
Estimated H-index: 1
Promoting the browning of white fat may be a potential means of combating obesity. Therefore, in this study, we investigated the effect of resveratrol (RES) on the body weight and browning of white fat in high-fat diet (HFD)-induced obese mice and the potential associated mechanism in vivo. Eight-week-old male mice were randomized to receive different treatments: (1), chow without any additional treatment (chow); (2), chow plus 0.4% resveratrol (chow-RES); (3), HFD without any additional treatme...
Published on Nov 1, 2018in Nature Reviews Gastroenterology & Hepatology23.57
Cornelia M. Ulrich61
Estimated H-index: 61
(UofU: University of Utah),
Caroline Himbert4
Estimated H-index: 4
(UofU: University of Utah)
+ 1 AuthorsStephen D. Hursting51
Estimated H-index: 51
(UNC: University of North Carolina at Chapel Hill)
Obesity increases the risk of multiple gastrointestinal cancers and worsens disease outcomes. Conversely, strong inverse associations have emerged between physical activity and colon cancer and possibly other gastrointestinal malignancies. The effect of weight loss interventions — such as modifications of diet and/or physical activity or bariatric surgery — remains unclear in patients who are obese and have gastrointestinal cancer, although large clinical trials are underway. Human intervention ...
Published on Sep 1, 2018in Journal of Lipid Research4.74
Ursula A. White9
Estimated H-index: 9
(Pennington Biomedical Research Center),
Mark Fitch17
Estimated H-index: 17
(University of California, Berkeley)
+ 2 AuthorsEric Ravussin99
Estimated H-index: 99
(Pennington Biomedical Research Center)
Published on Aug 1, 2018in European Journal of Clinical Investigation2.78
Emilio Molina-Molina2
Estimated H-index: 2
(University of Bari),
Raquel Lunardi Baccetto2
Estimated H-index: 2
(University of Bari)
+ 3 AuthorsPieroPortincasa42
Estimated H-index: 42
(University of Bari)
Published on Jul 1, 2018in British Journal of Sports Medicine11.64
Neil A. Smart29
Estimated H-index: 29
(UNE: University of New England (United States)),
Nicola King11
Estimated H-index: 11
(PSU: Plymouth State University)
+ 2 AuthorsGudrun Dieberg16
Estimated H-index: 16
(UNE: University of New England (United States))
Objective Exercise training has been shown to have beneficial effects on liver function in adults overweight or with fatty liver disease. To establish which exercise programme characteristics were likely to elicit optimal improvements. Design Systematic review and meta-analysis of randomised, controlled trials. Data sources PubMed, CINAHL and Cochrane controlled trials registry searched (1966 to 2 October 2015). Eligibility criteria for selecting studies Exercise intervention, with or without di...
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